Lipoprotein-Associated Phospholipase A2: A Risk Factor for Ischemic Stroke?

Year 2018, Volume: 17 Issue: 2, 28 - 35, 30.12.2018

Berna Alkan , Semra Öztürk Mungan

Abstract

Aim: The aim of the study is to investigate whether
there is an association between lipoprotein associated phospholipase A2 (Lp-PLA2)
and stroke ocurrence.

Methods: Fifty-two patients with acute ischemic stroke
within the 24 hours of the event and age and gender matched 42 control subjects
were enrolled to the study. This is a randomised, case-controlled, observational
study, involving patients and control subjects admitted to the Neurology Department
of Ankara Numune Education and Research Hospital between December 2009 and May 2010.

Results: The mean Lp-PLA2 level was 207.3±107.3
ng/ml in the patient group, and 128.6±10.3 ng/ml in
controls. The difference between patients and control groups were statistically
significant (p<0.01).

Conclusion: The results of our study revealed that
Lp-PLA2 plays a role in ischemic stroke and can be considered as an early
indicator for atherosclerosis. There is still need for new comprehensive
studies with larger patient groups in order to elucidate an accurate deduction.

Keywords: Atherosclerosis,  ischemic stroke, lipoprotein-associated phospholipase
A2, risk factors.

Keywords

Atherosclerosis, ischemic stroke, lipoprotein-associated phospholipase A2

Lipoprotein-İlişkili Fosfolipaz A2: İskemik İnme için bir Risk Faktörü mü?

Abstract

Amaç: Çalışmanın amacı, lipoprotein
ile ilişkili fosfolipaz A2 (Lp-PLA2) ile inme oluşumu arasında bir ilişki olup
olmadığını araştırmaktır.

Yöntem: Çalışma kapsamında 24
saatiçerisinde akut iskemik inme teşhisi konmuş 53 hasta ile hasta grubu yaş ve
cinsiyetine uygun 42 kontrol denek incelendi. Bu araştırma Aralık 2009 ve Mayıs
2010 tarihleri ​​arasında Ankara Numune Eğitim ve Araştırma Hastanesi Nöroloji
Bölümüne başvuran hastaları ve kontrol konularını içeren randomize, vaka
kontrollü, gözlemsel bir çalışmadır.

Bulgular: Çalışmamızda, Lp-PLA2'nin ortalama 
düzeylerinin hasta grubunda 207.3 ± 107.3 ng/ml, kontrol grubunda ise
128.6 ± 10.3 ng/ml olduğu, hasta ve kontrol grubu arasındaki farkın ise
istatistiksel olarak anlamlı olduğu bulunmuştur (p <0.01).

Sonuç: Çalışmamızın sonuçları,
Lp-PLA2'nin iskemik inmede rol oynadığını ve ateroskleroz için erken bir
gösterge olarak değerlendirilebileceğini gösterdi. Kesin bir sonuca ulaşabilmek
için daha geniş hasta grupları ile kapsamlı çalışmalara ihtiyaç vardır.

Keywords

Ateroskleroz, iskemik inme

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