Free Radicals, Reactive Oxygen Species and Relationship with Oxidative Stress

Year 2018, Volume: 13 Issue: 3, 373 - 379, 25.12.2018

Efe Kurtdede , Mert Pekcan , Hilal Karagül

https://doi.org/10.17094/ataunivbd.326899

Cited By: 3

Abstract

Fluorine is a highly reactive chemical element and a member of halogen family. Fluorides entry into the organism

and cells that increases the production of superoxide. Superoxide generates hydrogen peroxide, peroxynitrite, and hydroxyl

radicals, and plays a decisive role at the relationship between fluorine and reactive oxygen species (ROS). The increase in ROS

causes oxidative damage in lipid, protein, and DNA molecules. As a result of contact with fluoride, an increase in gene

expression levels encoding stress related response factors in the body, signal transduction compounds, and apoptosis related

proteins occurs. Assessment of these effects at the cellular level of fluor is important in terms of suggesting a new solution

to the problem of fluorosis in Turkey. Fluoride levels were determined in water, soil, plant and sheep urine, tooth, bone

samples in the areas of Ağrı, Van, Muğla, Eskişehir, Kırşehir, Çorum, Ankara, Hatay in Turkey. Results were evaluated to find

out fluor toxicosis. In this review, the effect of fluoride in the living organism is addressed at cellular level, and the effect of

fluoride on free radicals, ROS and oxidative stress formation is discussed.

Keywords

Fluoride, Free Radicals, ROS, Oxidative Stress, ROS

Florun Serbest Radikaller, Reaktif Oksijen Türleri ve Oksidatif Stres ile İlişkileri

Abstract

Flor halojen ailesinin bir üyesi olup elektronegatifliği yüksek bir elementtir. Florun organizmaya ve hücre içerisine girişiyle

süper oksit üretimi artar. Bunun sonucunda ortaya çıkan hidrojen peroksit, peroksinitrit ve hidroksil radikalleri florun reaktif

oksijen türleri (ROS) ile ilişkisinde belirleyici rol oynar. ROS’daki artış lipid, protein ve DNA moleküllerinde yıkımlanmaya sebep

olur. Florid İle temas sonucunda vücutta stres cevabı faktörlerinde, sinyal transdüksiyon bileşiklerinde, ve apopitozisle ilişkili

proteinleri kodlayan gen ekspresyon düzeylerinde artış ortaya çıkar. Florun hücresel düzeydeki bu etkilerinin

değerlendirilmesi, Türkiye’de var olan florozis sorununa yeni çözüm önerilebilmesi açısından önem arz etmektedir.

Ülkemizde, bugüne kadar yapılan çalışmalarda Muğla, Eskişehir, Kırşehir, Çorum, Ankara, Konya, Hatay, Van ve Ağrı illerinde

su, toprak, bitki, koyun idrarı, diş ve kemik örneklerinde flor düzeyleri belirlenmiş ve flor zehirlenmesi hakkında

değerlendirmeler yapılmıştır. Bu kapsamda flor'un canlı organizmadaki etkisine hücresel düzeyde değinilerek flor'un serbest

radikaller, ROS ve oksidatif stres oluşumuna etkisi değerlendirilmiştir.

Keywords

Flor, Serbest Radikaller, ROS, Oksidatif Stres, Serbest Radikaller

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