Kanser Hastalarında Fertilitenin Korunmasında Kullanılan Kriyoprezervasyon Yöntemleri

Year 2018, Volume: 1 Issue: 2, 17 - 26, 15.10.2018

Gülnaz Kervancıoğlu

Abstract

Günümüzde erken tanı ve tedavilerdeki gelişmelerle kanser hastalarında sağ kalım süreleri

uzamıştır. Kanserli hastanın onkoloji tedavisinden sonra da üreme yeteneğinin korunması

yaşam kalitesinin yükseltilmesinde önemli bir yer tutmaktadır. Erişkin kadın ve erkeklerde

olgun üreme hücrelerine ulaşmak mümkündür. Embriyo ve oosit dondurulmasında vitrifikasyon

yöntemi, spermatozoa ve testis hücre süspansiyonu dondurulmasında yavaş dondurma yöntemi,

over dokusu dondurulmasında ise her iki yöntem tercih edilmektedir. Prepubertal dönemde

ise gonad dokularının yani üreme kök hücrelerinin kriyoprezervasyonu tek seçenek olarak

karşımıza çıkmaktadır. Ancak prepubertal testis dokusunun kriyoprezervasyonu henüz deneysel

aşamadadır. Kanser hastaları için fertilite restorasyon tekniklerindeki gelişmeler, yakın bir

gelecekte kliniklerde rutin olarak uygulanabilmesi açısından umut vadetmektedir. Ancak

prepubertal erkek çocuklarda testis dokusundaki spermatogonyal kök hücrelerin güvenli ve en

uygun şekilde kriyoprezervasyonunu sağlayacak detaylı araştırmalara ihtiyaç vardır.

Keywords

Kriyoprezervasyon, Fertilite prezervasyonu, Prepubertal testis, Kanserde kriyoprezervasyon

References

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