Evaluation of Kidney Functions in Patients with Cirrhosis

Year 2025, Volume: 8 Issue: 1, 31 - 35, 18.03.2025

Ahmet Uyanıkoğlu , Süleyman Sari

Abstract

Introduction: Renal functions are frequently impaired in patients with cirrhosis. In this study, it was aimed to evaluate kidney functions in patients with cirrhosis.
Materials and Methods: The cross-sectional study were included 321 cirrhosis patients. Imaging, laboratory, and clinical approaches were used to diagnose cirrhosis. The Modification of Diet in Renal Diseases Study (MDRD) formula, which is based on serum creatinine, was used to calculate glomerular filtration rate (GFR).
Results: Of 321 cirrhotic patients, 189 (58%) were male, mean age was 55.6 ± 15.1 years, age range was 18-91 years. While 116 (36%) of the patients were compensated, 205 (64%) were decompensated. Etiological causes of cirrhosis 134 (42%) hepatitis B, 98 (30%) cryptogenic, 46 (14%) hepatitis C, 10 Wilson (3%), 10 delta hepatitis (3%), 23 (8%) other causes (alcoholic cirrhosis, cardiogenic cirrhosis, Budd-Chiari, biliary cirrhosis etc.).
The mean GFR of the patients was 96.2 ± 27.8 ml/min. While GFR was within the normal range in 205 patients (63%), it was below the normal range in 118 (37%) patients. Of the patients with low GFR, 87 (73%) were at stage 1, 23 (20%) were at stage 2, 6 (5%) were at stage 3 and 2 (2%) were at the limit of end-stage renal disease.
Conclusion: The most common etiological cause in our region in patients with cirrhosis is hepatitis B, cryptogenic in the second place and hepatitis C in the third place. Nearly two-thirds of the patients had decompensated cirrhosis, and at least one-third of all cirrhotic patients had kidney injury.

Keywords

cirrhosis, kidney injury, glomerular filtration rate

Siroz Hastalarında Böbrek Fonksiyonlarının Değerlendirilmesi

Abstract

Amaç: Siroz hastalarında böbrek fonksiyonları sıklıkla bozulmaktadır. Bu çalışmada sirozlu hastalarda böbrek fonksiyonlarının değerlendirilmesi amaçlanmıştır.
Materyal - Metod: Çalışmaya kesitsel olarak sirozu olan 321 hasta alınmıştır. Siroz tanısı klinik, laboratuvar ve görüntüleme yöntemleri ile konulmuştur. Glomerüler filtrasyon hızı (GFR) serum kreatinin temelli Modification of Diet in Renal Disaeses Study (MDRD) formülüyle hesaplanmıştır.
Bulgular: Sirotik 321 hastanın, 189’u erkek (%58), yaş ortalaması 55.6 ± 15.1, yaş dağılımı 18-91 yaş idi. Hastaların 116’sı (%36) kompanse iken, 205’i (%64) dekompanse idi. Sirozun etyolojik nedenleri 134 (%42) hepatit B, 98 (%30) kriptojenik, 46 (%14) hepatit C, 10 Wilson (%3), 10 delta hepatiti (%3), 23 (%8) diğer nedenler (alkolik siroz, kardiyojenik siroz, Budd-Chiari, biliyer siroz vs) idi.
Hastaların ortalama GFR’si 96.2 ± 27.8 ml/dk idi. GFR 205 hastada (%63) normal sınırlarda iken, 118 hastada (%37) normal sınırın altındaydı. GFR düşük olan hastalardan 87’si (%73) evre 1, 23’ü(%20) evre 2, 6’sı (%5) evre 3 ve 2’si (%2) son dönem böbrek yetmezliği sınırında idi.
Sonuç: Sirozlu hastalarda bölgemizde en sık etyolojik neden hepatit B, ikinci sırada kriptojenik, üçüncü sırada hepatit C’dir. Hastaların üçte ikiye yakını dekompanse siroz olup, tüm sirotik hastaların en az üçte birinde böbrek hasarı vardı.

Keywords

siroz, böbrek hasarı, glomerüler filtrasyon hızı

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