NEW THIOPHENE BEARING DIMETHYL-5-HYDROXY ISOPHTALATE ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES

Year 2018, Volume: 19 Issue: 1, 43 - 49, 31.03.2018

Hakan Ünver , Zerrin Canturk

https://doi.org/10.18038/aubtda.335519

Abstract

Thiophene belongs to a class of heterocyclic
compounds. In this study, three new dimethyl-5-hydroxy isophtalate derived thiophene esters were
successfully synthesized and characterized by FT-IR, elemental analysis, ¹H-NMR,
¹³C-NMR and HR-Mass techniques. Synthesized compounds antimicrobial
effects were tested on Staphylococcus aureus (ATCC
25923); Enterococcus faecalis  (ATCC 29212); Enterococcus faecalis (ATCC
51922); Klebsiella pneumoniae (ATCC 700603); Pseudomonas aeruginosa (ATCC
27853); Escherichia coli (ATCC 35218); Escherichia coli (ATCC
25922) and Candida albicans (ATCC
90028); Candida glabrata (ATCC 90030); Candida krusei (ATCC
6258); Candida parapsilosis (ATCC 22019). Compound C₁ showed
the highest antimicrobial activity, possessing the same potential as
chloramphenicol against, P. aeruginosa ATCC 27853. According to MTT assays, this compound was identified as non-toxic.

Keywords

Thiophene, Antibacterial, Anticandidal, MIC, Ketokanazole

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