BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ

Sıdıka Sinem Akdeniz; Pelin Aydın

Review

BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ

Year 2019, Volume: 46 Issue: 3, 179 - 186, 31.12.2019

Sıdıka Sinem Akdeniz Pelin Aydın

Abstract

Kemik defektleri; tümör cerrahisi, kist enükleasyonları, enfeksiyonlar, konjenital ve gelişimsel malformasyonlar, travma, kist enükleasyonları gibi çeşitli nedenlerle oluşabilmektedir. Kemik iyileşme süreci yumuşak dokuya göre daha uzun sürdüğünden; araştırmacılar da iyileşme sürecini hızlandırmak, uygulanan tekniklerin etkinliğini arttırmak, bu defektlerde estetik ve fonksiyonel olarak tam bir onarım sağlamak için yeni materyal arayışlarına girmişler ve bu amaçla kimyasal ajanları da incelemişlerdir. Bu derlemede Mecsina Hemostopper ve Ankaferd Blood Stopper’ın kemik iyileşmesine olan etkilerinden ve bu kanama durdurucu ajanların yapılan hayvan deney çalışmalarındaki etkinliğinden bahsedilecektir.

Keywords

Mecsina, Ankaferd, Kemik iyileşmesi

References

1. Andersson L, Kahnberg KE, Pogrel MA. Oral and Maxillofacial Surgery. John Wiley & Sons; 2012.
2. Miloro M, Ghali G, Larsen P, Waite P. Peterson's Principles of Oral and Maxillofacial Surgery. PMPH-USA: 2004.
3. Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. International Journal of Oral & Maxillofacial Implants 2009; 24.
4. Roberts WE, Hartsfield JK. Bone development and function: genetic and environmental mechanisms. Seminars in Orthodontics, ed., Elsevier; 2004, p 100.
5. İsler SC, Demircan S, Cakarer S, Cebi Z, Keskin C, Soluk M, Yuzbasioglu E. Effects of folk medicinal plant extract Ankaferd Blood Stopper® on early bone healing. Journal of Applied Oral Science 2010; 18:409.
6. Bouxsein M, Turek T, Blake C, D’Augusta D, Li X, Stevens M, Seeherman H, Wozney J. Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J Bone Joint Surg Am 2001; 83:1219.
7. Nikolidakis D, Meijer GJ, Oortgiesen DA, Walboomers XF, Jansen JA. The effect of a low dose of transforming growth factor β1 (TGF-β1) on the early bone-healing around oral implants inserted in trabecular bone. Biomaterials 2009; 30:94.
8. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 1998; 85:638.
9. Beyazit Y, Kurt M, Kekilli M, Goker H, Haznedaroglu IC. Evaluation of hemostatic effects of Ankaferd as an alternative medicine. Altern Med Rev 2010; 15:329–36.
10. Haznedaroglu BZ, Beyazit Y, Walker SL, Haznedaroglu IC. Pleiotropic cellular, hemostatic, and biological actions of Ankaferd hemostat. Crit Rev Oncol Hematol 2012; 83:21–34.
11. Özyurt A, Elmas C, Seymen CM, Peker VT, Altunkaynak B, Güngör MN. Effects of Low Level Laser Therapy with A Herbal Extract on Alveolar Bone Healing. Journal of Oral and Maxillofacial Surgery 2018; 76:287.
12. Goker H, Haznedaroglu I, Ercetin S, Kirazli S, Akman U, Ozturk Y, Firat H. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper®. Journal of International Medical Research 2008; 36:163.
13. Atay MH, Aslan NA, Aktimur S, Buyukkaya P, Kelkitli E, Turgut M, et al. Safety and efficacy of ankaferd hemostat (ABS) in the chemotherapy-induced oral mucositis. UHOD – Uluslararasi Hematol Derg 2015; 25:166-71.
14. Akbal E, Köklü S, Karaca G, Astarci HM, Koçak E, Taş A, Beyazıt Y, Topçu G, et al. Beneficial effects of Ankaferd Blood Stopper on caustic esophageal injuries: An experimental model. Dis Esophagus 2012; 25:188-94.
15. Simsek HO, Tuzum MS, Baykul T, Gurer İE, Bassorgun Cİ. Experimental investigation of the effects of a blood stopper agent (Ankaferd Blood Stopper) on bone surfaces. Turk J Hematol 2013; 30: 177-183.
16. Cakir M, Karaca IR, Firat A, Kaymaz F, Bozkaya S. Experimental evaluation of the effects of Ankaferd Blood Stopper and collagenated heterologous bone graft on bone healing in sinus floor augmentation. Int J Oral Maxillofac Implants 2015; 30: 279-285.
17. Tanık A, Güler Doğru A, Akpolat V, Acun Kaya F, Sarıbaş E, Gül M, et al. Investigation ofthe effect of combined useof alloplasticbased tricalcium phosphate bone graftand anihemorrhagic plant extract (ABS)on bone regeneration in surgically induced bone defectsin nondiabetic rats: an experimental animal study. Turk J Med Sci. 2018 Dec; 12: 48(6):1302-1314.
18. Hallac ZL, Histological and biochemical evoluation of the effect of medical plant extract Mecsina Hemostopper application on secondary wound healing. (Ph. D. Thesis), Gazi university Institute of health sciences, April 2018.
19. Çiçek M, Tumer MK, Yeni bir hemostatik ajan olan Mecsina Hemostopper’ın farklı testlerle sitotoksisitesinin değerlendirilip, kalvarial osteoblast proliferasyonuna etkisinin araştırılması. Dicle Tıp Dergisi / Dicle Med J 2018; 45 (3): 291-296.
20. Bachiega TF, de Sousa JPB, Bastos JK, Sforcin JM. Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages. Journal of Pharmacy and Pharmacology 2012; 64:610.
21. Kılıçoğlu Serin, S. Mikroskobi Düzeyinde Kırık İyileşmesi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 2002; 55(2):143-150.
22. Cruess, RL. Healing of bone,tendon and ligament: Fractures. 2nd Ed. Philadelphia: Lippincott Co; 1984.
23. Ovalle WK, Nahirney PC, Netter FH. Netter's essential histology. 1st ed. Philadelphia: Saunders/Elsevier; 2008.
24. Altunatmaz K. Kırık iyileşmesinin biyolojisi ve biyolojik osteosentez. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 2004; 30:141-47.107.
25. Einhorn TA. The cell and molecular biology of fracture healing. Clinical Orthopedics Related Research 1998; 7-21.
26. Lavine LS, Grodzinsky AJ. Electrical stimulation of repair of bone. American Journal of Bone and Joint Surgery 1987; 69(4):626-30.
27. Lieberman JR, Friedlaender G.E. Bone Regeneration and Repair. Biology and Clinical Applications. Totowa NJ: Humana Press; 2005.
28. Ham AW, Cormack DH. Ham's histology. 9th edition. Philadelphia: Lippincott; 1987.
29. Gartner LP, Hiatt JL. Cartilage and Bone. Color Textbook of Histology. 2nd edition. Philadelphia: Saunders Elsevier; 2007.
30. Miller MD. Bone. In: Miller MD, Thomson SR, Hart JA, editors. Review of Orthopaedics, 6th edition. Philadelphia: Saunders; 1996.
31. Li G, White G., Connolly C, DM. Cell Proliferation and Apoptosis During Fracture Healing. Journal of Bone Mineral Research 2002; 17(5):791-99.
32. Aksoy C. Kırık İyileşmesi. Hacettepe Üniversitesi Tıp Fakültesi Ortopedi Dergisi 2004; 43(3):1-4.
33. Dogan H, Ozcelik B, Gedikoglu G, Senel S. The effect of calcitonin on osseous healing in guinea pig mandible. Journal of Endodontics 2001; 27:160-163.
34. Sheela ML, Ramakrishna MK, Salimath BP. Angiogenic and proliferative effects of the cytokine VeGF in ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra. Int Immunopharmacol 2006; 6:494-8.
35. Ernst E, Marz RW, Sieder C. Acute bronchitis: effectiveness of Sinupret. Comparative study with common expectorants in 3,187 patients. Fortschritte der Medizin 1997; 115:52-3.
36. Barka EA, Belarbi A, Hachet C, Nowak J. Audran JC. Enhancement of in vitro growth and resistance to gray mould of Vitis vinifera co-cultured with plant growth-promoting rhizobacteria. FeMS Microbiol Lett 2000; 186:91-5.
37. Yamakoshi J, Kataoka S, Koga T, Ariga T. Proanthocyanidin- rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1999; 142:139-49.
38. Zhao J, Wang J, Chen Y, Agarwal R. Antitumor promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5- 3'-gallate as the most effective antioxidant constituent. Carcinogenesis 1999; 20:1737- 45.
39. Matsuda H, Ando S, Kato T, Morikawa T, Yoshikawa M. Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity. Bioorg Med Chem 2006; 14:138-42.
40. Testai L, Chericoni S, Calderone V, Nencioni G, Nieri P, Morelli I, et al. Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies. J ethnopharmacol 2002; 81:105-9.
41. Legssyer A, Ziyyat A, Mekhfi H, Bnouham M. Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta. Phytotherapy Research 2002; 16:503-7.
42. Lee KG, Shibamoto T. Antioxidant property of aroma extract isolated from clove buds Syzygium aromaticum. Food Chemistry 2001; 74(4): 443-448.
43. Cai L, Wu CD. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. Journal of Natural Products 1996; 59(10): 987-990.
44. Atalay Y. Aşil tendonu zedelenmiş sıçanlarda Hypericum perforatum ve Calendula officinalis bitki tentürlerinin etkilerinin incelenmesi, Doktora Tezi 2011; Dumlupınar Üniversitesi, Kütahya.
45. Peşin İ. Hypericum perforatum L. ve Hypericum scabrum L. bitkilerinin yara iyileştirici ve antienflamatuvar aktiviteleri üzerinde çalışmalar, Yüksek Lisans Tezi 2007; Gazi Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara.
46. Londonkar RL, Poddar PV. Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals. World Journal of Gastrointestinal Oncology 2009; 1(1): 82.

The Effects of Herbal Blood Stoppers on Bone Regeneration

Year 2019, Volume: 46 Issue: 3, 179 - 186, 31.12.2019

Sıdıka Sinem Akdeniz Pelin Aydın

Abstract

Bone defects could occur in various circumstances such as tumor surgery, cyst enucleations, infections, congenital and developmental malformations or trauma. Since bone healing lasts longer than soft tissue healing; research by using new materials and chemical agents has been made to accelerate the healing process, increase the effectiveness of the applied techniques and to provide a complete repair of these defects in terms of aesthetics and function. In this review, the effects of Mecsina Hemostopper and Ankaferd Blood Stopper on bone healing and their effectiveness in experimental studies will be discussed.

Keywords

Mecsina, Ankaferd, Bone healing

References

1. Andersson L, Kahnberg KE, Pogrel MA. Oral and Maxillofacial Surgery. John Wiley & Sons; 2012.
2. Miloro M, Ghali G, Larsen P, Waite P. Peterson's Principles of Oral and Maxillofacial Surgery. PMPH-USA: 2004.
3. Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. International Journal of Oral & Maxillofacial Implants 2009; 24.
4. Roberts WE, Hartsfield JK. Bone development and function: genetic and environmental mechanisms. Seminars in Orthodontics, ed., Elsevier; 2004, p 100.
5. İsler SC, Demircan S, Cakarer S, Cebi Z, Keskin C, Soluk M, Yuzbasioglu E. Effects of folk medicinal plant extract Ankaferd Blood Stopper® on early bone healing. Journal of Applied Oral Science 2010; 18:409.
6. Bouxsein M, Turek T, Blake C, D’Augusta D, Li X, Stevens M, Seeherman H, Wozney J. Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J Bone Joint Surg Am 2001; 83:1219.
7. Nikolidakis D, Meijer GJ, Oortgiesen DA, Walboomers XF, Jansen JA. The effect of a low dose of transforming growth factor β1 (TGF-β1) on the early bone-healing around oral implants inserted in trabecular bone. Biomaterials 2009; 30:94.
8. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 1998; 85:638.
9. Beyazit Y, Kurt M, Kekilli M, Goker H, Haznedaroglu IC. Evaluation of hemostatic effects of Ankaferd as an alternative medicine. Altern Med Rev 2010; 15:329–36.
10. Haznedaroglu BZ, Beyazit Y, Walker SL, Haznedaroglu IC. Pleiotropic cellular, hemostatic, and biological actions of Ankaferd hemostat. Crit Rev Oncol Hematol 2012; 83:21–34.
11. Özyurt A, Elmas C, Seymen CM, Peker VT, Altunkaynak B, Güngör MN. Effects of Low Level Laser Therapy with A Herbal Extract on Alveolar Bone Healing. Journal of Oral and Maxillofacial Surgery 2018; 76:287.
12. Goker H, Haznedaroglu I, Ercetin S, Kirazli S, Akman U, Ozturk Y, Firat H. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper®. Journal of International Medical Research 2008; 36:163.
13. Atay MH, Aslan NA, Aktimur S, Buyukkaya P, Kelkitli E, Turgut M, et al. Safety and efficacy of ankaferd hemostat (ABS) in the chemotherapy-induced oral mucositis. UHOD – Uluslararasi Hematol Derg 2015; 25:166-71.
14. Akbal E, Köklü S, Karaca G, Astarci HM, Koçak E, Taş A, Beyazıt Y, Topçu G, et al. Beneficial effects of Ankaferd Blood Stopper on caustic esophageal injuries: An experimental model. Dis Esophagus 2012; 25:188-94.
15. Simsek HO, Tuzum MS, Baykul T, Gurer İE, Bassorgun Cİ. Experimental investigation of the effects of a blood stopper agent (Ankaferd Blood Stopper) on bone surfaces. Turk J Hematol 2013; 30: 177-183.
16. Cakir M, Karaca IR, Firat A, Kaymaz F, Bozkaya S. Experimental evaluation of the effects of Ankaferd Blood Stopper and collagenated heterologous bone graft on bone healing in sinus floor augmentation. Int J Oral Maxillofac Implants 2015; 30: 279-285.
17. Tanık A, Güler Doğru A, Akpolat V, Acun Kaya F, Sarıbaş E, Gül M, et al. Investigation ofthe effect of combined useof alloplasticbased tricalcium phosphate bone graftand anihemorrhagic plant extract (ABS)on bone regeneration in surgically induced bone defectsin nondiabetic rats: an experimental animal study. Turk J Med Sci. 2018 Dec; 12: 48(6):1302-1314.
18. Hallac ZL, Histological and biochemical evoluation of the effect of medical plant extract Mecsina Hemostopper application on secondary wound healing. (Ph. D. Thesis), Gazi university Institute of health sciences, April 2018.
19. Çiçek M, Tumer MK, Yeni bir hemostatik ajan olan Mecsina Hemostopper’ın farklı testlerle sitotoksisitesinin değerlendirilip, kalvarial osteoblast proliferasyonuna etkisinin araştırılması. Dicle Tıp Dergisi / Dicle Med J 2018; 45 (3): 291-296.
20. Bachiega TF, de Sousa JPB, Bastos JK, Sforcin JM. Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages. Journal of Pharmacy and Pharmacology 2012; 64:610.
21. Kılıçoğlu Serin, S. Mikroskobi Düzeyinde Kırık İyileşmesi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 2002; 55(2):143-150.
22. Cruess, RL. Healing of bone,tendon and ligament: Fractures. 2nd Ed. Philadelphia: Lippincott Co; 1984.
23. Ovalle WK, Nahirney PC, Netter FH. Netter's essential histology. 1st ed. Philadelphia: Saunders/Elsevier; 2008.
24. Altunatmaz K. Kırık iyileşmesinin biyolojisi ve biyolojik osteosentez. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 2004; 30:141-47.107.
25. Einhorn TA. The cell and molecular biology of fracture healing. Clinical Orthopedics Related Research 1998; 7-21.
26. Lavine LS, Grodzinsky AJ. Electrical stimulation of repair of bone. American Journal of Bone and Joint Surgery 1987; 69(4):626-30.
27. Lieberman JR, Friedlaender G.E. Bone Regeneration and Repair. Biology and Clinical Applications. Totowa NJ: Humana Press; 2005.
28. Ham AW, Cormack DH. Ham's histology. 9th edition. Philadelphia: Lippincott; 1987.
29. Gartner LP, Hiatt JL. Cartilage and Bone. Color Textbook of Histology. 2nd edition. Philadelphia: Saunders Elsevier; 2007.
30. Miller MD. Bone. In: Miller MD, Thomson SR, Hart JA, editors. Review of Orthopaedics, 6th edition. Philadelphia: Saunders; 1996.
31. Li G, White G., Connolly C, DM. Cell Proliferation and Apoptosis During Fracture Healing. Journal of Bone Mineral Research 2002; 17(5):791-99.
32. Aksoy C. Kırık İyileşmesi. Hacettepe Üniversitesi Tıp Fakültesi Ortopedi Dergisi 2004; 43(3):1-4.
33. Dogan H, Ozcelik B, Gedikoglu G, Senel S. The effect of calcitonin on osseous healing in guinea pig mandible. Journal of Endodontics 2001; 27:160-163.
34. Sheela ML, Ramakrishna MK, Salimath BP. Angiogenic and proliferative effects of the cytokine VeGF in ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra. Int Immunopharmacol 2006; 6:494-8.
35. Ernst E, Marz RW, Sieder C. Acute bronchitis: effectiveness of Sinupret. Comparative study with common expectorants in 3,187 patients. Fortschritte der Medizin 1997; 115:52-3.
36. Barka EA, Belarbi A, Hachet C, Nowak J. Audran JC. Enhancement of in vitro growth and resistance to gray mould of Vitis vinifera co-cultured with plant growth-promoting rhizobacteria. FeMS Microbiol Lett 2000; 186:91-5.
37. Yamakoshi J, Kataoka S, Koga T, Ariga T. Proanthocyanidin- rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1999; 142:139-49.
38. Zhao J, Wang J, Chen Y, Agarwal R. Antitumor promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5- 3'-gallate as the most effective antioxidant constituent. Carcinogenesis 1999; 20:1737- 45.
39. Matsuda H, Ando S, Kato T, Morikawa T, Yoshikawa M. Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity. Bioorg Med Chem 2006; 14:138-42.
40. Testai L, Chericoni S, Calderone V, Nencioni G, Nieri P, Morelli I, et al. Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies. J ethnopharmacol 2002; 81:105-9.
41. Legssyer A, Ziyyat A, Mekhfi H, Bnouham M. Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta. Phytotherapy Research 2002; 16:503-7.
42. Lee KG, Shibamoto T. Antioxidant property of aroma extract isolated from clove buds Syzygium aromaticum. Food Chemistry 2001; 74(4): 443-448.
43. Cai L, Wu CD. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. Journal of Natural Products 1996; 59(10): 987-990.
44. Atalay Y. Aşil tendonu zedelenmiş sıçanlarda Hypericum perforatum ve Calendula officinalis bitki tentürlerinin etkilerinin incelenmesi, Doktora Tezi 2011; Dumlupınar Üniversitesi, Kütahya.
45. Peşin İ. Hypericum perforatum L. ve Hypericum scabrum L. bitkilerinin yara iyileştirici ve antienflamatuvar aktiviteleri üzerinde çalışmalar, Yüksek Lisans Tezi 2007; Gazi Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara.
46. Londonkar RL, Poddar PV. Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals. World Journal of Gastrointestinal Oncology 2009; 1(1): 82.

There are 46 citations in total.

Details

Primary Language	Turkish
Subjects	Dentistry
Journal Section	Review Articles
Authors	Sıdıka Sinem Akdeniz This is me Pelin Aydın
Publication Date	December 31, 2019
Published in Issue	Year 2019 Volume: 46 Issue: 3

Cite

APA	Akdeniz, S. S., & Aydın, P. (2019). BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ. Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi, 46(3), 179-186.
AMA	Akdeniz SS, Aydın P. BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ. AÜDHF dergisi. December 2019;46(3):179-186.
Chicago	Akdeniz, Sıdıka Sinem, and Pelin Aydın. “BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ”. Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi 46, no. 3 (December 2019): 179-86.
EndNote	Akdeniz SS, Aydın P (December 1, 2019) BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ. Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi 46 3 179–186.
IEEE	S. S. Akdeniz and P. Aydın, “BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ”, AÜDHF dergisi, vol. 46, no. 3, pp. 179–186, 2019.
ISNAD	Akdeniz, Sıdıka Sinem - Aydın, Pelin. “BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ”. Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi 46/3 (December 2019), 179-186.
JAMA	Akdeniz SS, Aydın P. BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ. AÜDHF dergisi. 2019;46:179–186.
MLA	Akdeniz, Sıdıka Sinem and Pelin Aydın. “BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ”. Ankara Üniversitesi Diş Hekimliği Fakültesi Dergisi, vol. 46, no. 3, 2019, pp. 179-86.
Vancouver	Akdeniz SS, Aydın P. BİTKİSEL KANAMA DURDURUCU AJANLARIN KEMİK REJENERASYONU ÜZERİNE OLAN ETKİNLİKLERİ. AÜDHF dergisi. 2019;46(3):179-86.

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