COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi

Sevinç Bakan; Şeyma Nur Deveboynu; Fatma Tayhan Kartal

Review

The Effect of Antioxidant Vitamins On Immunity In The COVID-19 Pandemic

Year 2020, Volume: 3 Issue: COVID-19, 140 - 148, 13.07.2020

Sevinç Bakan , Şeyma Nur Deveboynu Fatma Tayhan Kartal

Abstract

COVID-19 is a viral disease that affects the whole world, is seriously contagious and affects the respiratory system. Theimmune system protects the organism against pathogens such as viruses, bacteria, fungi. Although always active,the effectiveness of the immune system increases when the organism meets the pathogen. A number of vitaminsand minerals help the immune system to function properly. Molecules called free radicals highly reactive, potentiallyharmful that are capable of stabilizing molecules are called antioxidants. The ability of antioxidants to reduce theload of excessive free radicals helps maintain the structural integrity of tissues and cells in the immune system aswell as other systems in the body. Vitamins A, C, E cannot be synthesized in the body and vitamin D needs sun raysto be synthesized in the body and these have important functions in the full fulfillment of immune function and areessential nutrients with antioxidant properties. Each of these nutrients has its own functions. In this study, it is aimedto give information about the roles of antioxidant vitamins in supporting the immune system in COVID-19 pandemic.

Keywords

Antioxidant, COVID-19, Immunity, Vitamin

References

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COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi

Year 2020, Volume: 3 Issue: COVID-19, 140 - 148, 13.07.2020

Sevinç Bakan , Şeyma Nur Deveboynu Fatma Tayhan Kartal

Abstract

COVID-19 tüm dünyayı etkisi altına almış olan, ciddi şekilde bulaşıcı ve solunum sistemini etkileyen viral bir hastalıktır.Bağışıklık sistemi virüs, bakteri, mantar gibi patojenlere karşı organizmayı korur. Her zaman aktif olmasına rağmen,organizmanın patojen ile karşılaştığında bağışıklık sisteminin etkinliği artar. Bir takım vitamin ve mineraller bağışıklıksisteminin sağlıklı bir şekilde işlemesine yardımcıdır. Serbest radikaller olarak adlandırılan, oldukça reaktif, potansiyelolarak zararlı molekülleri stabilize etme yeteneğine sahip moleküllere antioksidan denir. Antioksidanların fazla miktardabulunan serbest radikallerin yükünü azaltma özelliği, vücuttaki diğer sistemlerin yanı sıra bağışıklık sistemindekidoku ve hücrelerin de yapısal bütünlüğünü korumaya yardım eder. A, C, E vitaminleri vücutta sentezlenemeyen veD vitamini ise vücutta sentezlenmesi için güneş ışınlarına ihtiyaç duyan, bağışıklık fonsiyonunun tam olarak yerinegetirilmesinde önemli görevleri olan antioksidan özelliğe sahip esansiyel besin öğeleridir. Bu besin öğelerinin herbirinin kendine özgü işlevleri vardır. Bu çalışmada COVID-19 pandemisinde bağışıklık sisteminin desteklenmesindeantioksidan vitaminlerin rolleri ile ilgili bilgi verilmesi amaçlanmıştır.

Keywords

Antioksidan, Bağışıklık, COVID-19, Vitamin

References

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Adams, KK, Baker WL, Sobieraj DM. (2020). Myth Busters: Dietary Supplements and COVID-19. Annals of Pharmacotherapy, 106002802092805.
Agier J, Efenberger M, Brzezińska-Blaszczyk E. (2015). Cathelicidin impact on inflammatory cells. In Central European Journal of Immunology, 40(2): 225-235. https://doi.org/10.5114/ceji.2015.51359
Akbulut G. (2016). D Vitamini ve İmmün Sistem. Turkiye Klinikleri Nutrition and Dietetics - Special Topics, 2(2): 67–71.
Alsayed R, Adil H, Al-Hussin A, Hussain Z, Mohammed S, Yousif E. (2018). Antioxidant activity of vitamins against free radicals. International Journal of Research in Engineering and Innovation (IJREI), 2 (3): 249-252.
Aslan R. (2018). Vitaminler Oksidan Antioksidan Dengeyi Nasıl Etkiliyor? Göller Bölgesi Aylık Hakemli Ekonomi ve Kültür Dergisi, 6 (68): 69-73.
Atluri S, Laxmaiah M, Hirsch J. (2020). Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use. Pain Physician, 23(2): E71–E83.
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Butler MJ, Barrientos RM. (2020). The impact of nutrition on COVID-19 susceptibility and long-term consequences. In Brain, Behavior, and Immunity. Academic Press Inc.
Calder PC, Carr AC, Gombart AF, Eggersdorfer M. (2020). Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients, 12(4): 1–10.
Carr AC, Maggini S. (2017). Vitamin C and immune function. Nutrients, 9(11): 1–25.
Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. (2020). Features, Evaluation and Treatment Coronavirus (COVID-19). In StatPearls. Treasure Island (FL): StatPearls Publishing.
Chew BP. (1996). Importance of antioxidant vitamins in immunity and health in animals. Animal Feed Science and Technology, 59:103-114.
De Waele E, Malbrain MLNG, Spapen H. (2020). Nutrition in sepsis: A bench-to-bedside review. Nutrients, 12(2): 1–16.
Elmadfa I, Meyer AL. (2019). The Role of the Status of Selected Micronutrients in Shaping the Immune Function. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(8): 1100–1115.
Francenia Santos-Sánchez N, Salas-Coronado R, Villanueva-Cañongo C, Hernández-Carlos B. (2019). Antioxidant Compounds and Their Antioxidant Mechanism. In; Antioxidants, Shalaby E (Ed), 1-28, IntechOpen, London, UK,
Gombart AF, Pierre A, Maggini S. (2020). A review of micronutrients and the immune system–working in harmony to reduce the risk of infection. Nutrients, 12(1):236
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, & Bhattoa HP. (2020). Evidence that vitamin d supplementation could reduce risk of influenza and covid-19 infections and deaths. In Nutrients, 12(4): 988
Gibney MJ, Lanham-New SA, Cassidy A, Vorster HH. (2009). Introduction to Human Nutrition. 2nd Edition, United Kingdom; Wiley-Blackwell.
Hemilä H. (2016). Vitamin E administration may decrease the incidence of pneumonia in elderly males. Clinical Interventions in Aging, 11: 1379–1385.
Hemilä H, Chalker E. (2020). Vitamin C as a Possible Therapy for COVID-19. Infect Chemother, 52(2): 1–2.
Holick MF. (2005). The Vitamin D Epidemic and its Health Consequences. The Journal of Nutrition, 135(11): 2739S-2748S.
Huang Z, Liu Y, Qi G, Brand D, Zheng S. (2018). Role of Vitamin A in the Immune System. Journal of Clinical Medicine, 7(9): 258.
Jakovac H. (2020). COVID-19 and vitamin D-Is there a link and an opportunity for intervention? In American Journal of Physiology - Endocrinology and Metabolism, 318 (5): E589.
Kara M, Ekiz T, Ricci V, Kara Ö, Chang KV, Özçakar L. (2020). ‘Scientific Strabismus’ or Two Related Pandemics: COVID-19 & Vitamin D Deficiency. British Journal of Nutrition, 1–20.
Karabulut H, Gülay MŞ. (2016). Serbest Radikaller. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 4(1): 50-59.
Kashiouris MG, L’heureux M, Cable CA, Fisher BJ, Leichtle SW, Fowler AA. (2020). The emerging role of vitamin C as a treatment for sepsis. Nutrients, 12(2): 1–16.
Kim H, Jang M, Kim Y, Choi J, Jeon J, Kim J, Hwang Y, Kang JS, Lee WJ. (2016). Red ginseng and Vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. Journal of Pharmacy and Pharmacology, 68(3): 406–420.
Lee GY, Han SN. (2018). The role of vitamin E in immunity. In Nutrients, 10(11): 1614
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Li B, Wang Y, Shen F, Wu M, Li Y, Fang Z, Ye J, Wang L, Gao L, Yuan Z, Chen J. (2018). Identification of retinoic acid receptor agonists as potent hepatitis B virus inhibitors via a drug repurposing screen. Antimicrobial Agents and Chemotherapy, 62(12): e00465-18.
Martínez-Moreno J, Hernandez JC, Urcuqui-Inchima S. (2020). Effect of high doses of vitamin D supplementation on dengue virus replication, Toll-like receptor expression, and cytokine profiles on dendritic cells. Molecular and Cellular Biochemistry, 464(1–2): 169–180. https://doi.org/10.1007/ s11010-019-03658-w.
McCullough FSW, Northrop-Clewes CA, Thurnham DI. (1999). The effect of vitamin A on epithelial integrity. Proceedings of the Nutrition Society, 58(2): 289–293. https://doi. org/10.1017/S0029665199000403.
Messina G, Polito R, Monda V, Cipolloni L, Di Nunno N, Di Mizio G, Murabito P, Carotenuto M, Messina A, Pisanelli D, Valenzano A, Cibelli G, Scarinci A, Monda M, Sessa F. (2020). Functional role of dietary intervention to improve the outcome of COVID-19: A hypothesis of work. International Journal of Molecular Sciences, 21(9): 3104. https://doi.org/10.3390/ ijms21093104.
Meydani S, Lewin E, Wu D. (2018). Perspective: Should Vitamin E Recommendations for Older Adults Be Increased? Advenced in Nutrition, 9(5): 533–543. Moriguchi S, Muraga M. (2000). Vitamin E and immunity. In Vitamins and Hormones, 59:305–336. https://doi. org/10.1016/s0083-6729(00)59011-6.
Mosekilde L. (2005). Vitamin D and the elderly. Clinical Endocrinology, 62(3): 265–281. https://doi.org/10.1111/ j.1365-2265.2005.02226.x.
Nabzdyk CS, Bittner EA, Nabzdyk CS, Bittner EA. (2018). Vitamin C in the critically ill - indications and controversies. World Journal of Critical Care Medicine, 7(5):52–72. https://doi. org/10.5492/wjccm.v7.i5.52.
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Primary Language	Turkish
Subjects	Health Care Administration
Journal Section	Articles
Authors	Sevinç Bakan 0000-0002-8660-7756 Şeyma Nur Deveboynu This is me 0000-0002-1533-4973 Fatma Tayhan Kartal 0000-0001-8524-9048
Publication Date	July 13, 2020
Submission Date	July 2, 2020
Published in Issue	Year 2020 Volume: 3 Issue: COVID-19

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APA	Bakan, S., Deveboynu, Ş. N., & Tayhan Kartal, F. (2020). COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi. Avrasya Sağlık Bilimleri Dergisi, 3(COVID-19), 140-148.
AMA	Bakan S, Deveboynu ŞN, Tayhan Kartal F. COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi. EurasianJHS. July 2020;3(COVID-19):140-148.
Chicago	Bakan, Sevinç, Şeyma Nur Deveboynu, and Fatma Tayhan Kartal. “COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi”. Avrasya Sağlık Bilimleri Dergisi 3, no. COVID-19 (July 2020): 140-48.
EndNote	Bakan S, Deveboynu ŞN, Tayhan Kartal F (July 1, 2020) COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi. Avrasya Sağlık Bilimleri Dergisi 3 COVID-19 140–148.
IEEE	S. Bakan, Ş. N. Deveboynu, and F. Tayhan Kartal, “COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi”, EurasianJHS, vol. 3, no. COVID-19, pp. 140–148, 2020.
ISNAD	Bakan, Sevinç et al. “COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi”. Avrasya Sağlık Bilimleri Dergisi 3/COVID-19 (July 2020), 140-148.
JAMA	Bakan S, Deveboynu ŞN, Tayhan Kartal F. COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi. EurasianJHS. 2020;3:140–148.
MLA	Bakan, Sevinç et al. “COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi”. Avrasya Sağlık Bilimleri Dergisi, vol. 3, no. COVID-19, 2020, pp. 140-8.
Vancouver	Bakan S, Deveboynu ŞN, Tayhan Kartal F. COVID-19 Pandemisinde Bağışıklık Üzerine Antioksidan Vitaminlerin Etkisi. EurasianJHS. 2020;3(COVID-19):140-8.

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