Yağda Çözünen Vitaminler ve Bağırsak Mikrobiyotası Üzerine Etkileri

Year 2023, Volume: 6 Issue: 3, 116 - 122, 30.09.2023

Rabia Melda Karaağaç , Çağla Pınarlı

https://doi.org/10.53493/avrasyasbd.1262072

Cited By: 1

Abstract

Sağlığın ve hastalığın kilit düzenleyicisi olarak mikrobiyota, son zamanlarda popüler konulardan birisidir. Başta deri, ağız, solunum sistemi ve gastrointestinal kanal olmak üzere farklı vücut bölgelerinde mikrobiyota bulunmaktadır. Bağırsak mikrobiyotası, immün-modülasyon, konağın besin metabolizmasını düzenleme gibi pek çok etkisi bulunmaktadır. İnsan bağırsak mikrobiyotasının oluşumunda yaşamın erken dönemleri, özellikle ilk 3 yaş ön plana çıkmaktadır. Bağırsak mikrobiyotası, konağın normal fonksiyonlarını devam ettirmesinde ve işleyişinde önemli bir rol oynamaktadır. Bununla birlikte bağırsak mikrobiyotası, konak ile etkileşime girerek insan sağlığını olumlu veya olumsuz etkileyen çeşitli metabolik ürünleri sentezleyebilmektedir. Bu noktada vitaminler de çeşitli mekanizmalar yoluyla mikrobiyomu modüle etmektedirler. Vitaminler, vücutta birçok işlevi olan çok çeşitli moleküllerdir. Vitaminler, yağda çözünen ve suda çözünen vitaminler olarak iki temel sınıflana ayrılmaktadır. Vitaminlerin bağırsak mikrobiyotasındaki dolaylı etkileri arasında; konak bağışıklık tepkisini etkileme, enfeksiyonlara duyarlılığı değiştirme gibi şeyler bulunmaktadır. Mikrobiyom aynı zamanda bir vitamin üreticisidir, bu nedenle mikrobesin ögesi yeterliliğine ve bağırsaktaki bakteri topluluklarının stabilitesine katkıda bulunmaktadır. Tüm bu sebeplerle vitaminler, enerji kaynağı olarak kullanılmadan bağırsak mikrobiyomu üzerinde çift yönlü, doğrudan veya dolaylı etkilere sahip olabilmektedir. Bu çalışmanın amacı, yağda çözünen A, D, E, K vitaminlerinin bağırsak mikrobiyotası üzerine etkilerini literatür bilgileri ışığında derlemektir.

Keywords

Bağırsak, Mikrobiyota, Yağda çözünen vitaminler

Fat-Soluble Vitamins and Their Effects on Gut Microbiota

Abstract

As a key regulator of health and disease, the microbiota has been a hot topic recently. There are microbiota in different body parts, especially the skin, mouth, respiratory system and gastrointestinal tract. It has many effects such as gut microbiota, immune-modulation, regulating the host's food metabolism. The early stages of life, especially the first 3 years, come to the fore in the formation of the human gut microbiota. The gut microbiota plays an important role in the normal functioning and functioning of the host. In addition, the intestinal microbiota can synthesize various metabolic products that affect human health positively or negatively by interacting with the host. At this point, vitamins also modulate the microbiome through various mechanisms. Vitamins are a wide variety of molecules that have many functions in the body. Vitamins are divided into two basic classes, fat-soluble and water-soluble vitamins. Among the indirect effects of vitamins on the intestinal microbiota; There are things like affecting the host immune response, changing susceptibility to infections. The microbiome is also a producer of vitamins, thus contributing to micronutrient adequacy and stability of bacterial communities in the gut. For all these reasons, vitamins can have bidirectional, direct or indirect effects on the gut microbiome without being used as an energy source. The aim of this study is to compile the effects of fat-soluble vitamins A, D, E, and K on intestinal microbiota in the light of literature.

Keywords

Gut, Microbiota, Fat soluble vitamins

References

• Akimbekov, N. S., Digel, I., Sherelkhan, D. K., Lutfor, A. B., & Razzaque, M. S. (2020). Vitamin D and the Host-Gut Microbiome: A Brief Overview. Acta histochemica et cytochemica, 53(3), 33–42.
• Bashir, M., Prietl, B., Tauschmann, M., Mautner, S. I., Kump, P. K., Treiber, G., Wurm, P., Gorkiewicz, G., Högenauer, C., & Pieber, T. R. (2016). Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract. European journal of nutrition, 55(4), 1479–1489.
• Basu, T. K., & Donaldson, D. (2003). Intestinal absorption in health and disease: micronutrients. Best practice & research. Clinical gastroenterology, 17(6), 957–979.
• Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., Brigidi, P., & De Vos, W. (2010). Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PloS one, 5(5), e10667.
• Booth S. L. (2012). Vitamin K: food composition and dietary intakes. Food & nutrition research, 56, 10.3402/fnr. v56i0.5505.
• Campbell, Y., Fantacone, M. L., & Gombart, A. F. (2012). Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism. In european journal of nutrition 51(8), 899–907.
• Fakhoury, H., Kvietys, P. R., AlKattan, W., Anouti, F. A., Elahi, M. A., Karras, S. N., & Grant, W. B. (2020). Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. The journal of steroid biochemistry and molecular biology, 200, 105663.
• Frame, L. A., Costa, E., & Jackson, S. A. (2020). Current explorations of nutrition and the gut microbiome: a comprehensive evaluation of the review literature. Nutrition reviews, 78(10), 798–812.
• Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K., & Reid, G. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature reviews. Gastroenterology & hepatology, 14(8), 491–502.
• Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds. (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academies Press (US).
• Karl, J. P., Meydani, M., Barnett, J. B., Vanegas, S. M., Barger, K., Fu, X., Goldin, B., Kane, A., Rasmussen, H., Vangay, P., Knights, D., Jonnalagadda, S. S., Saltzman, E., Roberts, S. B., Meydani, S. N., & Booth, S. L. (2017). Fecal concentrations of bacterially derived vitamin K forms are associated with gut microbiota composition but not plasma or fecal cytokine concentrations in healthy adults. The American journal of clinical nutrition, 106(4), 1052–1061.
• Kong, J., Zhang, Z., Musch, M. W., Ning, G., Sun, J., Hart, J., Bissonnette, M., & Li, Y. C. (2008). Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. American journal of physiology. Gastrointestinal and liver physiology, 294(1), G208–G216.
• LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M. (2013). Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Current opinion in biotechnology, 24(2), 160–168.
• Liu, F., Cottrell, J. J., Furness, J. B., Rivera, L. R., Kelly, F. W., Wijesiriwardana, U., Pustovit, R. V., Fothergill, L. J., Bravo, D. M., Celi, P., Leury, B. J., Gabler, N. K., & Dunshea, F. R. (2016). Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat-stressed pigs. Experimental physiology, 101(7), 801– 810.
• Long, K. Z., Santos, J. I., Rosado, J. L., Estrada-Garcia, T., Haas, M., Al Mamun, A., DuPont, H. L., & Nanthakumar, N. N. (2011). Vitamin A supplementation modifies the association between mucosal innate and adaptive immune responses and resolution of enteric pathogen infections. The American journal of clinical nutrition, 93(3), 578–585.
• Luthold, R. V., Fernandes, G. R., Franco-de-Moraes, A. C., Folchetti, L. G., & Ferreira, S. R. (2017). Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals. Metabolism: clinical and experimental, 69, 76–86.
• Lv, Z., Wang, Y., Yang, T., Zhan, X., Li, Z., Hu, H., Li, T., & Chen, J. (2016). Vitamin A deficiency impacts the structural segregation of gut microbiota in children with persistent diarrhea. Journal of clinical biochemistry and nutrition, 59(2), 113–121.
• Meeker, S., Seamons, A., Maggio-Price, L., & Paik, J. (2016). Protective links between vitamin D, inflammatory bowel disease and colon cancer. World journal of gastroenterology, 22(3), 933–948.
• Nicholson, I., Dalzell, A. M., & El-Matary, W. (2012). Vitamin D as a therapy for colitis: a systematic review. Journal of Crohn's & colitis, 6(4), 405–411.
• O'Hara, A. M., & Shanahan, F. (2006). The gut flora as a forgotten organ. EMBO reports, 7(7), 688–693.
• Passos, M., & Moraes-Filho, J. P. (2017). Intestinal Microbiota in Digestive Diseases. Arquivos de gastroenterologia, 54(3), 255–262.
• Rajilić-Stojanović, M., Heilig, H. G., Molenaar, D., Kajander, K., Surakka, A., Smidt, H., & de Vos, W. M. (2009). Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environmental microbiology, 11(7), 1736–1751.
• Shapira M. (2016). Gut Microbiotas and Host Evolution: Scaling Up Symbiosis. Trends in ecology & evolution, 31(7), 539–549.
• Sivakumar, B., & Reddy, V. (1972). Absorption of labelled vitamin A in children during infection. The British journal of nutrition, 27(2), 299–304.
• Tabatabaeizadeh, S. A., Fazeli, M., Meshkat, Z., Khodashenas, E., Esmaeili, H., Mazloum, S., Ferns, G. A., Abdizadeh, M. F., & Ghayour-Mobarhan, M. (2020). The effects of high doses of vitamin D on the composition of the gut microbiome of adolescent girls. Clinical nutrition ESPEN, 35, 103–108.
• Tsugawa, N., & Shiraki, M. (2020). Vitamin K Nutrition and Bone Health. Nutrients, 12(7), 1909.
• Vergalito, F., Pietrangelo, L., Petronio Petronio, G., Colitto, F., Alfio Cutuli, M., Magnifico, I., Venditti, N., Guerra, G., & Di Marco, R. (2019). Vitamin E for prevention of biofilm-caused healthcare-associated infections. Open medicine (Warsaw, Poland), 15, 14–21.
• Wang, L., Liu, L., Liu, X., Xiang, M., Zhou, L., Huang, C., Shen, Z., & Miao, L. (2020). The gut microbes, Enterococcus and Escherichia-Shigella, affect the responses of heart valve replacement patients to the anticoagulant warfarin. Pharmacological research, 159, 104979.
• Zhang, Y. G., Wu, S., & Sun, J. (2013). Vitamin D, Vitamin D Receptor, and Tissue Barriers. Tissue barriers, 1(1), e23118.
• Zhu, D., Wang, Y., Pang, Y., Liu, A., Guo, J., Bouwman, C. A., West, C. E., & van Breemen, R. B. (2006). Quantitative analyses of beta-carotene and retinol in serum and feces in support of clinical bioavailability studies. Rapid communications in mass spectrometry: RCM, 20(16), 2427–2432.