Çocuklarda B12 Vitamini Eksikliği ve İlişkili Bulguların Sıklığı

Year 2022, , 503 - 508, 04.10.2022

Hilal Aydın , Oğuzhan Korkut , Ezgi Özden , Demet Can

https://doi.org/10.53424/balikesirsbd.1142063

Abstract

Amaç: Bu çalışmanın amacı, çocuk nörolojisi polikliniğine çeşitli semptomlarla başvuran hastalarda vitamin B12 eksikliği ile ilişkili klinik bulguları belirlemek ve güncel literatür ışığında tartışmaktır. Gereç ve Yöntem: Bu retrospektif kesitsel çalışmaya 01.08.2019-01.08.2021 tarihleri arasında Balikesir Üniversitesi Tıp Fakültesi Çocuk Nöroloji Polikliniğine başvuran ve B12 vitamini düzeyi 250 ng/mL'nin altında olan 1 ay-18 yaş arası çocuklar dahil edildi. Bulgular: Çalışmaya 63 (%39.1) kadın ve 98 (%60.9) erkek 161 olgu dahil edildi. Hastaların yaş ortalaması 7.43±5.77 (0-17) yıl idi. Her iki cinsiyetteki hastaların büyük çoğunluğu 0-6 yaş grubundaydı. Vitamin B12 eksikliği olan hastaların %81.98'inde nörolojik bulgular, %18.02'sinde nörolojik olmayan bulgular mevcuttu. En sık görülen nörolojik bulgu nöromotor retardasyon (N=73, %45.34), ardından nöbetler (N=33, %20.50) idi. Tüm hastalarda ortalama B12 vitamini düzeyi 167.70±45.17 (58-250) pg/ml idi. B12 vitamini ve ferritin düzeyleri veya tam kan sayımı parametreleri [Hb, Htc ve MCV] açısından erkek ve kız çocukları arasında istatistiksel olarak anlamlı fark saptanmadı (sırasıyla p=0.428, p=0.646, p=0.110, p=0.128, p=0.864). Sonuç: Bu çalışma, sağlık çalışanları için hastalıkla ilişkili olarak karşılaştığımız klinik tablolar hakkında genel bir değerlendirme sunmaktadır.

Keywords

B12 Vitamini, Çocuk, Eksiklik, Bulgu, Tedavi

Frequency of Vitamin B12 Deficiency and Associated Findings in Children

Abstract

Objective: The purpose of this study was to determine clinical findings associated with vitamin B12 deficiency in patients presenting to the pediatric neurology department with various different symptoms and to discuss these in the light of the current literature. Materials and Methods: Children aged between one month and 18 years presenting to the Balikesir University Medical Faculty pediatric neurology clinic, Turkey, between 01.08.2019-01.08.2021 and with vitamin B12 levels lower than 250 ng/mL were included in this retrospective, cross-sectional study. Results: One hundred sixty-one cases were included in the study 63 (39.1%) female and 98 (60.9%) male. The patients’ mean age was 7.43±5.77 (0-17) years. The majority of patients of both genders were in the 0-6 age group. Neurological findings were present in 81.98% of patients with Vitamin B12 deficiency, and non-neurological findings in 18.02%. The most frequent neurological finding was neuromotor retardation (N=73, 45.34%), followed by seizures (N=33, 20.50%). The mean Vitamin B12 level among all the patients was 167.70±45.17 (58-250) pg/ml. No statistically significant difference was determined between boys and girls in terms of Vitamin B12 and ferritin levels or complete blood count parameters [Hb, Htc, and MCV] (respectively p=0.428, p=0.646, p=0.110, p=0.128, p=0.864). Conclusions: This study provides a general evaluation for health professionals regarding clinical presentations encountered by us in association with the disease.

Keywords

Vitamin B12, Children, Treatment, Deficiency, Sign

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