FREE RADICALS AND THE RELATIONSHIP WITH STRESS

Year 2018, Volume: 7 Issue: 1, 51 - 55, 30.04.2018

Ayşen Altıner Hasan Atalay , Tanay Bilal

Abstract

Free radicals are produced continuously by normal metabolic processes, but the production rate is increased in several inflammatory diseases or other conditions. Normally the body is protected by a broad interval of defense mechanisms against the reactive oxygen metabolites and their toxic products. Imbalance between the reactive oxygen metabolites and their secure disposal can initiate lipid peroxidation and oxidative chain reactions. Transport operation that is one of the important activities of farm management is one of factors affecting the animal welfare, and creating stress in the animals. The deteriorated oxidant-antioxidant balance has been suggested to play a role in the pathophysiology of the diseases occurring after transport in cattle. Heat stress is reported to induce oxidative stress by increasing the formation of reactive oxygen species in the cells. A rise in glutathione peroxidase activity was observed as a result of adaptation mechanisms against physical stress after the prolonged exercise in humans. Sheep maintained at high density have had the weaker qualited and lower milk production. The aim of this review was to give information about free radikals and to explain the oxidant and antioxidant status during stress

Keywords

Free radicals, antioxidant, stress

SERBEST RADİKALLER VE STRES İLE İLİŞKİSİ

Abstract

Serbest radikaller normal metabolik işlemlerle devamlı olarak üretilirler fakat üretim hızları bazı yangısal veya diğer hastalık şartlarında artar. Normal olarak vücut, reaktif oksijen metabolitleri ile onların toksik ürünlerine karşı geniş bir savunma mekanizmaları aralığı tarafından korunur. Reaktif oksijen metabolitleri ve onların güvenli bir şekilde imhası arasındaki dengesizlik, oksidatif zincir reaksiyonlarını ve lipid peroksidasyonunu başlatabilir. Çiftlik yönetiminin önemli aktivitelerinden biri olan taşınma işlemi, hayvan refahını etkileyen ve hayvanlarda stres yaratan etmenlerden biridir. Sığırlarda taşınma sonrasında ortaya çıkan hastalıkların patofizyolojisinde, bozulan oksidan-antioksidan dengenin rol oynadığı ileri sürülmüştür. Sıcaklık stresinin de hücrelerde reaktif oksijen türleri oluşumunu arttırarak oksidatif stresi uyardığı bildirilmektedir. İnsanlarda uzun süreli egzersizden sonra, fiziksel stres faktörlerine karşı uyum mekanizmasının bir sonucu olarak glutatyon peroksidaz aktivitesinde yükselme gözlenmiştir. Yüksek yoğunlukta tutulan koyunlar daha zayıf kalitede ve daha düşük süt verimine sahip olmuşlardır. Derlemenin amacı serbest radikaller hakkında bilgi vererek stres sırasındaki oksidan ve antioksidan durumu ortaya koymaktır.

Keywords

Serbest radikaller, antioksidan, stres

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