Primary giant cell tumor of soft tissue on mandibular region: a case report and literature review

Year 2013, Volume: 2 Issue: 2, 71 - 82, 08.09.2013

Fahrettin Göze , Ahmet Muslehiddinoğlu

https://doi.org/10.12808/bcs.v2i2.28

Abstract

Abstract

Primary giant cell tumor of the soft tissue was first defined by Salm and Sissons as a tumoral lesion histologically identical to the giant cell tumor of the bone and clinically benign even though having some local recurrences. However, subsequent studies have demonstrated that besides benign forms, tumor also had potentially malignant and malignant forms. In this case, we evaluated a tumor seen on a woman at 27 years old and rare in location (mandibular region) and diagnosed as 'primary giant cell tumor of the soft tissue' (PGCT-ST). We also impressed on the differential diagnosis of the case by evaluating the morphological and immunohistochemical properties of the tumor. Moreover, since potentially malignant and malignant forms of the tumor were also defined, we reviewed the criteria of differential diagnosis and the literature again and tried to make the clinical behavior of the tumor clear.

Keywords: Low grade giant cell tumor, soft tissue, mandibular region

Özet

Yumuşak dokuların primer dev hücreli tümörü ilk olarak Salm ve Sissons tarafından histolojik olarak kemiğin dev hücreli tümörüne benzer ve klinik olarak bazı lokal rekürrensleri olsa da benign bir lezyon olarak tanımlanmıştır; ama daha sonraki çalışmalar benign formların yanında tümörün potansiyel olarak malign veya malign formlarının olduğunu göstermiştir. Bu olguda 27 yaşında bir kadında ve mandibuler bölge gibi nadir bir yerde saptanan yumuşak dokunun primer dev hücreli tümörü olarak tanımlanan bir tümör sunulmuştur. Bu olgu dolayısı ile bu tümörlerin morfolojik ve immünohistopatolojik özellikleri ele alınmıştır. Bu yaklaşımla tümörün ayırıcı tanısı literatür eşliğinde ele alınarak tümörün klinik özelliklerinin açıklanmasına çalışılmıştır.

Anahtar Sözcükler: Düşük dereceli dev hücreli tümör, yumuşak doku, mandibular bölge

Keywords

Low grade giant cell tumor, soft tissue, mandibular region

References

• Salm R, Sissons HA (1972) Giant-cell tumours of soft tissues. J Pathol 107: 27-39.
• Oliveira AM, DeiTos AP, Fletcher CDM, Nascimento AG (2000) Primary giant cell tumor of soft tissues. A study of 22 cases. Am J Surg Pathol 24(2): 248-56.
• O'Connell JX, Wehrli BM, Nielsen GP, Rosenberg AE (2000) Giant cell tumors of soft tissue. A clinicopathologic study of 18 benign and malignant tumors. Am J Surg Pathol 24(3): 386-95.
• Guccion JG, Enzinger FM (1972) Malignant giant cell tumor of soft parts. An analysis of 32 cases. Cancer 29: 1518-29.
• Soule EH, Enriques P (1972) Atypical fibrous histiocytoma, malignant fibrous histiocytoma, malignant histiocytoma and epithelioid sarcoma. A comparative study of 65 tumors. Cancer 30: 128-43.
• Weiss SW, Goldblum JR. Fibrohistiocytic tumors of intermediate malignancy. In: Weiss SW, Goldblum JR, eds. Enzinger and Weiss's Soft Tissue Tumors, 4th edn. CV Mosby, St. Louis, London, Philadelphia, Sydney, Toronto, 2001, 491-531.
• Alguacil- Garcia A, Unni KK, Goellner GR (1997) Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. Cancer 40: 244-53
• Angervall L, Hagmar B, Kindlom L, Merek C (1981) Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiografic and microangiografic study. Cancer 47: 736-47.
• Nascimento AG (1993) Giant cell tumor of soft parts. Mod Pathol 6: 9a. Abstract.
• Folpe AL, Weiss SW (1992) Soft tissue giant cell tumor of low malignant potential: proposal for a re-classification of giant cell tumor malignant fibrous histiocytoma. Mod Pathol 12: l la. Abstract.
• Oliveira AM, DeiTos AP, Fletcher CDM, Nascimento AG (1992) Giant cell tumor of soft tissues: a clinicopathologic analysis of 21 cases. Mod Pathol 12: 14a. Abstract.
• Folpe AL, Morris RJ, Weiss S W (1999) Soft tissue giant cell tumor of low malignant potential: a proposal for re-classification of malignant giant cell tumor of soft parts. Mod Pathol 12: 894-902.
• Unni KK (1996) Giant cell tumor (osteoclastoma). In: Unni KK, ed. Dahlin's Bone Tumors: General aspects and data on 11087 cases. 5th ed. Philadelphia: LippincottRaven 263-83.
• Huvos AG (1991) Giant cell tumor of bone. In: Huvos AG, ed. Bone tumors: Diagnosis, treatment and prognosis. 2nd ed. Philadelphia, PA: WB Saunders 429-68.
• Rodrigues-Peralto JL, Lopez-Baren F, Sanchez-Herrera S, Atienza M (1994) Primary aneurysmal cyst of soft tissues (extraosseous aneurysmal cyst). Am Surg Pathol 18: 632-6.
• Shannon P, Bedard Y, Bell R, Kandel R (1997) Aneurysmal cyst of soft tissue: report of a case with serial magnetic resonance imaging and biopsy. Hum Pathol 28: 255-7.
• Enzinger FM, Zhank RY (1988) Plexiform fibrohistiocytic tumor presenting in children and young adults: an analysis of 65 cases. Am J Surg Pathol 12: 818-26.
• Hollowood K, Holley MP, Fletcher CDM (1991) Plexiform fibrohistiocytic tumour: clinicopathological, immunohistochemical and ultrastructural analysis in favour of a myofibroblastic lesion. Histopathology 19: 503-13.
• Salomao DR, Nascimento AG (1997). Plexiform fibrohistiocytic tumor with systemic metastases: a case report. Am J Surg Pathol 21: 469-76.
• Thomazy V, Nagy A, Gal I, Nemes Z (1994). Plexiform fibrohistiocytic tumour with novel features. Histopathology 25: 165-9.
• Zelger B, Weinlich G, Steiner H, Zelger BG, Egarter-Vigl E (1997) Dermal and subcutaneous variants of plexiform fibrohistiocytic tumor. Am J Surg Pathol 21: 235 82