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THE ROLE OF CRP / ALBUMIN RATIO IN THE CARPAL TUNNEL SYNDROME

Year 2020, Volume: 4 Issue: 3, 19 - 23, 27.11.2020

Abstract

Aim: Carpal Tunnel Syndrome is the most common cause of mononeuropathy, the pathogenesis and natural course of which has not been fully understood.
Materials and Methods: In this retrospective study, we aimed to collect data on the role of inflammation and oxidative stress in etiopathogenesis by determining the serum C-reactive protein (CRP) / albumin ratio according to the stage of patients with a CT diagnosis and to determine the possible effects of this ratio on the progression of the disease. Records of patients aged 18-65 who were admitted to our EMG outpatient clinic with a pre-diagnosis of CTS in the last six months of 2019 were collected. According to the neurological examination and EMG results, 50 control and 50 CTS patient records were collected.
Results: According to the EMG result, bilateral moderate CTS in 12, unilateral moderate CTS in 10, unilateral severe CTS in 15, bilateral severe CTS in 10, and bilateral mild CTS in 3. CRP, albumin and CRP / albumin ratio between the control group and stages of CTS were not statistically significant.
Conclusion: CRP / albumin ratio may return to normal in the subacute-chronic process since our patients don’t have acute CTS. Therefore, in the choice of treatment, analgesics with more analgesic properties rather than anti-inflammatory properties can be selected in the subacute and chronic process. This idea can be supported by increasing the number of patients in the acute process.

References

  • 1. Bland JD. Carpal tunnel syndrome. Curr Opin Neurol 2005; 18: 581 – 85.
  • 2. Takasu S, Takatsu S, Kunitomo Y. Serum hyaluronic acid and interleukin-6 as possible markers of carpal tunnel syndrome in chronic hemodialysis patients. Artificial organs 1994; 18 : 420 –24.
  • 3. Stevens JC. The electrodiagnosis of carpal tunnel syndrome. American Association of Electrodiagnostic Medicine Muscle Nerve 1997; 20 : 1477 – 86.
  • 4. Kimura J.The carpal tunnel syndrome localization of conduction abnormalities within the distal segment of the median nerve. Brain 1979;102 : 619-35.
  • 5. Luan YY, Yao YM. The Clinical Significance and Potential Role of C-Reactive Protein in Chronic Inflammatory and Neurodegenerative Diseases. Front Immunol 2018;9:1302.
  • 6. Altun Y. , Tak AZA. Can serum C-Reactive Protein and Procalcitonin levels associate with Carpal Tunnel Syndrome? Medical Science and Discovery 2019; 6:18-23.

KARPAL TÜNEL SENDROMUNDA CRP / ALBUMIN ORANININ ROLÜ

Year 2020, Volume: 4 Issue: 3, 19 - 23, 27.11.2020

Abstract

Amaç: Karpal tünel sendromu, patogenezi ve doğal seyri tam olarak anlaşılamayan en yaygın mononöropati nedenidir.
Gereç ve Yöntemler: Bu retrospektif çalışmada KTS tanısı alan hastalarda evreye göre serum C-reaktif protein (CRP) / albümin oranını belirleyerek inflamasyon ve oksidatif stresin etiyopatogenezdeki rolü hakkında veri toplamayı ve bu oranın hastalığın ilerlemesi üzerindeki olası etkilerini belirlemeyi amaçladık. EMG polikliniğimize 2019 yılının son altı ayında KTS ön tanısıyla başvuran 18-65 yaş arası hastaların kayıtları toplandı. Nörolojik muayene ve EMG sonuçlarına göre 50 kontrol ve 50 KTS hasta kaydı toplandı.
Bulgular: EMG sonucuna göre iki taraflı orta KTS 12'sinde, tek taraflı orta KTS 10'unda, tek taraflı şiddetli KTS 15'inde, iki taraflı şiddetli KTS 10'unda ve iki taraflı hafif KTS 3‘ünde vardı. Kontrol grubu ve KTS evreleri arasında CRP, albümin ve CRP / albümin oranı istatistiksel olarak anlamlı bulunmadı.
Sonuç: Hastalarımızda akut KTS olmadığı için subakut-kronik süreçte CRP / albümin oranı normale dönebilir. Bu nedenle tedavi seçiminde, subakut ve kronik süreçte antiinflamatuvar özelliklerden çok analjezik özelliklere sahip analjezikler seçilebilir. Akut süreçteki hasta sayısı artırılarak bu fikir desteklenebilir.

References

  • 1. Bland JD. Carpal tunnel syndrome. Curr Opin Neurol 2005; 18: 581 – 85.
  • 2. Takasu S, Takatsu S, Kunitomo Y. Serum hyaluronic acid and interleukin-6 as possible markers of carpal tunnel syndrome in chronic hemodialysis patients. Artificial organs 1994; 18 : 420 –24.
  • 3. Stevens JC. The electrodiagnosis of carpal tunnel syndrome. American Association of Electrodiagnostic Medicine Muscle Nerve 1997; 20 : 1477 – 86.
  • 4. Kimura J.The carpal tunnel syndrome localization of conduction abnormalities within the distal segment of the median nerve. Brain 1979;102 : 619-35.
  • 5. Luan YY, Yao YM. The Clinical Significance and Potential Role of C-Reactive Protein in Chronic Inflammatory and Neurodegenerative Diseases. Front Immunol 2018;9:1302.
  • 6. Altun Y. , Tak AZA. Can serum C-Reactive Protein and Procalcitonin levels associate with Carpal Tunnel Syndrome? Medical Science and Discovery 2019; 6:18-23.
There are 6 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section RESEARCH ARTICLE
Authors

Nermin Tepe 0000-0003-4148-2539

Burak Gülcen 0000-0002-1706-353X

Publication Date November 27, 2020
Published in Issue Year 2020 Volume: 4 Issue: 3

Cite

APA Tepe, N., & Gülcen, B. (2020). THE ROLE OF CRP / ALBUMIN RATIO IN THE CARPAL TUNNEL SYNDROME. Balıkesir Medical Journal, 4(3), 19-23.