A Case of Acute Dystonia Induced by Metoclopramide
Year 2015,
Volume: 5 Issue: 3, 62 - 64, 14.10.2015
Nesrin Yılmaz
,
Lütfü Hanoğlu
Abstract
Metoclopramide is an antiemetic drug that antagonizes dopamine D2 receptors. Acute dystonia induced by metoclopramide is a rare disease which is more common in children, young women and patients with a positive family history. The history of the drug intake and typical clinical presentation are essential for the correct diagnosis. In this case, we would like to present a patient with metoclopramide induced acute dystonia that we were first confused about the diagnosis and that recurrent biperiden injections were effective for the therapy.
References
- van Harten PN, Hoek HW, Kahn RS. Acute dystonia induced by drug treatment. BMJ. 1999;319(7210):623-626.
- Albibi R, McCallum RW. Metoclopramide: pharmacology and clinical application. Ann Intern Med. 1983;98(1):86-95.
- Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. Br Med J. 1985;291(6500):930-932.
- MillerLG, Jankovic J. Metoclopramide-induced movement disorders. Clinical findings with a review of the literature. Arch Intern Med. 1989;149(11): 2486-2492.
- Miller LG, Jankovic J.Neurologic approach to drug-induced movement disorders: a study of 125 patients. South Med J.1990;83(5):525-532.
- Allan SG, Leonard RC, Cornbleet MA, Smyth JF. Dystonic reactions due to metoclopramide. Lancet.1984(8371);1:283.
- Guala A, Mittino D, Ghini T, Quazza G. Are metoclopramide dystonias familial? Pediatr Med Chir. 1992;14(6):617-618. van der Padt A, van Schaik RH, Sonneveld P. Acutedystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms. Neth J Med.2006;64(5):160-162.
- Bateman DN, Craft AW, Nicholson E, Pearson ADJ. Dystonic reactions and the pharmacokinetics of metoclopramide in children. Br J Clin Pharmacol. 1983;15(5):557-559.
- Kerr GW. Dystonic reactions: two case reports. J Accid Emerg Med. 1996;13(3):221-222.
- Yis U, Ozdemir D, Duman M, Unal N. Metoclopramide induced dystonia in children: two case reports.Eur J Emerg Med.2005;12(3):117-119.
- Dingli K, Morgan R, Leen C. Acute dystonic reaction caused by metoclopramide, versus tetanus. BMJ. 2007;334(7599):899-900.
- Söğüt Ö, Kaya H, Solduk L, Dokuzoğlu MA. Metoklopramid kullanımına bağlı gelişen akut distoni: iki olgu sunumu. Akademik Acil Tıp Olgu Sunumları Dergisi. 2011;2(3):50-53.
- Cézard C, Nisse P, Quaranta S, Peucelle D, Mathieu- Nolf M. Acute dystonia from metoclopramide in children. Therapie 2003;58(4):367-370. 64
METOKLOPRAMİD KULLANIMINA BAĞLI GELİŞEN AKUT DİSTONİLİ BİR OLGU
Year 2015,
Volume: 5 Issue: 3, 62 - 64, 14.10.2015
Nesrin Yılmaz
,
Lütfü Hanoğlu
Abstract
Metoklopramid D2 dopamin reseptörlerini antagonize eden bir antiemetiktir. Metoklopramid kullanımına bağlı gelişen akut distoni; çocuklarda, genç bayanlarda ve aile öyküsü pozitif olanlarda daha sık görülen nadir bir hastalıktır. Doğru tanıyı koymak için ilaç kullanım anamnezi ve tipik klinik prezentasyonun olması gereklidir. Bu olguda ilk başta ayırıcı tanıda zorlandığımız, tedavisinde tekrarlayan biperiden enjeksiyonlarının etkili olduğu metoklopramid kullanımına bağlı gelişen akut distonisi olan bir vakayı sunmaktayız.
References
- van Harten PN, Hoek HW, Kahn RS. Acute dystonia induced by drug treatment. BMJ. 1999;319(7210):623-626.
- Albibi R, McCallum RW. Metoclopramide: pharmacology and clinical application. Ann Intern Med. 1983;98(1):86-95.
- Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. Br Med J. 1985;291(6500):930-932.
- MillerLG, Jankovic J. Metoclopramide-induced movement disorders. Clinical findings with a review of the literature. Arch Intern Med. 1989;149(11): 2486-2492.
- Miller LG, Jankovic J.Neurologic approach to drug-induced movement disorders: a study of 125 patients. South Med J.1990;83(5):525-532.
- Allan SG, Leonard RC, Cornbleet MA, Smyth JF. Dystonic reactions due to metoclopramide. Lancet.1984(8371);1:283.
- Guala A, Mittino D, Ghini T, Quazza G. Are metoclopramide dystonias familial? Pediatr Med Chir. 1992;14(6):617-618. van der Padt A, van Schaik RH, Sonneveld P. Acutedystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms. Neth J Med.2006;64(5):160-162.
- Bateman DN, Craft AW, Nicholson E, Pearson ADJ. Dystonic reactions and the pharmacokinetics of metoclopramide in children. Br J Clin Pharmacol. 1983;15(5):557-559.
- Kerr GW. Dystonic reactions: two case reports. J Accid Emerg Med. 1996;13(3):221-222.
- Yis U, Ozdemir D, Duman M, Unal N. Metoclopramide induced dystonia in children: two case reports.Eur J Emerg Med.2005;12(3):117-119.
- Dingli K, Morgan R, Leen C. Acute dystonic reaction caused by metoclopramide, versus tetanus. BMJ. 2007;334(7599):899-900.
- Söğüt Ö, Kaya H, Solduk L, Dokuzoğlu MA. Metoklopramid kullanımına bağlı gelişen akut distoni: iki olgu sunumu. Akademik Acil Tıp Olgu Sunumları Dergisi. 2011;2(3):50-53.
- Cézard C, Nisse P, Quaranta S, Peucelle D, Mathieu- Nolf M. Acute dystonia from metoclopramide in children. Therapie 2003;58(4):367-370. 64