NÖTROFİL/LENFOSİT VE PLATELET/LENFOSİT ORANLARI AZOOSPERMİ VE ANORMAL SPERM PARAMETRELERİ İÇİN PREDİKTİF MARKER OLARAK KULLANILABİLİR Mİ? Is It Possible to Use Neutrofil/Lymphocyte and Platelet/Lymphocyte Ratio as a Predictive Marker for Azoospermia and Abnormal Semen Parameters?

Year 2019, Volume: 9 Issue: 3, 102 - 107, 16.09.2019

Ünal Öztekin , Mehmet Caniklioğlu Sercan Sarı Volkan Selmi Abdullah Gürel Emin Gürtan Ayşen Caniklioğlu Levent Işıkay

Abstract

ÖZET

Amaç: Erkek faktörlü infertilite toplunda sık karşılaşılan bir durumdur. Bu çalışmada amacımız basit ve ucuz

bir tetkik olan tam kan sayımı parametrelerini kullanarak, pro-inflamatuar belirteçler olan nötrofil/lenfosit

ve platelet/lenfosit oranlarının, azoospermi, oligoastenozoospermi ve normal sperm parametrelerinde prediktif

olarak kullanılabilirliğini araştırmaktır.

Materyal ve Metod: Kliniğimize erkek faktörlü infertilite araştırılması nedeniyle başvurmuş ve çalışma kriterlerini

sağlayan 358 hastanın kayıtları retrospektif olarak incelendi. Hastalar Azoospermi grubu (Grup 1),

Oligoastenoteratozoospermi grubu (Grup 2), Normal sperm parametrelerine sahip grup (Grup 3) olmak üzere

üç gruba ayrıldı. Gruplar nötrofil, lenfosit, platelet değerleri ile nötrofil/lenfosit oranı ve platelet/lenfosit

oranları açısından karşılaştırıldı.

Bulgular: Demografik veriler ile nötrofil, lenfosit ve platelet değerleri açısından gruplar arası anlamlı fark

saptanmadı. Nötrofil/Lenfosit oranı ve Platelet/Lenfosit oranı açısından istatistiksel anlamlı fark yoktu (sırasıyala

p: 0,745, p: 0,998).

Sonuç: Azospermi ve oligoastenoteratozoospermi olasılığını öngörebilmek için NLO ve PLO değerlerini prediktif

bir marker olarak kullanılmasını önermiyoruz.

Anahtar Sözcu¨kler: Azospermi; Nötrofil/Lenfosit Oranı; Platelet/Lenfosit Oranı

ABSTRACT

Objective: Male factor infertility is a common disease. In this study, we aimed to investigate the predictability

of neutrophil / lymphocyte and platelet / lymphocyte ratios in azoospermic, oligoasthenozoospermic

and normal semen parameters by using whole blood count parameters which are simple and inexpensive.

Material and Methods: The data of 358 patients who admitted to our clinic due to male factor infertility

were investigated retrospectively. The patients were divided into three groups as azoospermia group (Group

1), oligoastenoteratozoospermia group (Group 2) and normal group (Group 3). The groups were compared

in terms of neutrophil, lymphocyte, platelet values, neutrophil / lymphocyte ratio and platelet / lymphocyte

ratios.

Results: No significant difference was found between the groups in terms of demographic data, neutrophil,

lymphocyte and platelet values. There was no statistically significant difference in Neutrophil / Lymphocyte

ratio and Platelet / Lymphocyte ratio (p: 0.745, p: 0.998).

Conclusion: We do not recommend the use of NLR and PLO to predict the probability of azoospermia and

oligoasthenoteratozoospermia.

Keywords: Azoospermia; Neutrophil/Lymphocyte Ratio; Platelet/ Lymphocyte Ratio

Keywords

NÖTROFİL/LENFOSİT VE PLATELET/LENFOSİT ORANLARI AZOOSPERMİ VE ANORMAL SPERM PARAMETRELERİ İÇİN PREDİKTİF MARKER OLARAK KULLANILABİLİR Mİ? Is It Possible to Use Neutrofil/Lymphocyte and Platelet/Lymphocyte Ratio as a Predictive Marker for Azoospermia and Abnormal Semen Parameters?

References

• 1. Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, Tournaye H. Guidelines on Male Infertility (EAU). 2018. 2. Azenabor A, Ekun AO, Akinloye O. Impact of Inflammation on Male Reproductive Tract. J Reprod Infertil. 2015;16(3):123-9. 3. Hamada A, Esteves SC, Nizza M, Agarwal A. Unexplained male infertility: diagnosis and management. Int Braz J Urol 2012;38:576-94. 4. Ilhan G, Atmaca FFV, Altan E, Zebitay AG, Sozen H, Akyol H et al. Evaluation of Neuthrophil-Lymphocyte Ratio, Platelet- Lymphocyte Ratio, Red Blood Cell Distrubution Widht-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency. Journal of Family and Reproductive Health. 2016;10(4):211-6. 5. Weidner, W, Pilatz, A, Diemer, T, Schuppe, H. C, Rusz, A, Wagenlehner, F. Male urogenital infections: Impact of infection and inflammation on ejaculate parameters. World Journal of Urology 2013;31:717–23. 6. Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am. 2002;29(4):817-27. 7. Güneş M, Umul M, Altok M, Akyuz M, İşoğlu CS, Uruc F, et al. Predictive role of hematologic parameters in testicular torsion. Korean J Urol 2015;56:324–9. 8. Kaya H, Ertas F, Islamoglu Y, Kaya Z, Atılgan ZA, Cil H, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clinical and Applied Thrombosis/Hemostasis 2012;20(1):50–4. 9. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012; 26;5(1):2. 10. Guthrie, GJ, Charles, KA, Roxburgh, CS, Horgan, PG, McMillan, DC, Clarke, SJ. The systemic inflammation‐based neutrophil‐lymphocyte ratio: Experience in patients with cancer. Critical Reviews in Oncology Hematology 2013;88(1):218-30.