Heterologue Skin Microbiota Transplantation for Treatment of Sarcoptic Manges in Two Dogs with Zoonotic Transmission

Year 2022, , 52 - 56, 30.12.2022

Kerem Ural , Hasan Erdoğan , Songül Erdoğan

https://doi.org/10.58833/bozokvetsci.1207900

Abstract

In the present case report, the authors inspected the feasibility of transferring unenriched (however moistured and pre-biotic
treated) skin microbiota communities between two heterologous hosts, namely heterologue skin microbiota transplantation (hSmT), [from
apparently healthy donor to other relevant and diseased dogs, with scabies, separately]. Two cross-bred, client-owned dogs (belonging to the
same owners) with a diagnosis of scabies and intense pruritus were enrolled. Nivea Clear Up Strips were attached in a total of 3 various
apparently healthy integumentary tissue of another donor dog and allowed to dry for 10-12 minutes. This was followed by peeling off, all 3
strips were then transferred to diseased skin tissue (laterolateral area in 2 dogs with scabies, separately) which were also irrigated with
isotonic and allowed to attach for at least 12-15 minutes. Finally, all 3 strips were removed. Both in case I and II, Vas pruritus scores were
decreased significantly beginning on day 0 (initial hSmT day) to days 21. Vas pruritus score ranged between 8-10 and 7-9, in case I and II,
respectively, prior to hSmT [days -14 to day 0]. Prior to hSmT all skin scrape positivity were deemed available on days -14 to 0, whereas
after day 2 of hSmT, all 2 dogs gave negative skin scraping results till the end of the study. It should not be unwise to draw preliminary
conclusion that transfer of unenriched skin microbiota from a healthy donor to the diseased dogs with scabies, should have helped hastening
clinical and parasitological recovery by manipulation of cutaneous microenvironment

Keywords

Dog, microbiome manuplation, microbiome modulation, Skin Microbiota Transplantation, Köpek, Mikrobiyom Manuplasyonu, Mikrobiyom modülasyonu

Zoonotik Bulaşı olan İki Sarkoptik Uyuzlu Köpeğin Sağaltımında Heterojen Deri Mikrobiyota Transplantasyonu

Abstract

Bu vaka raporunda yazarlar, iki heterolog konakçı arasında (görünüşe göre sağlıklı donörden diğer uyuzlu hasta köpeklere ayrı ayrı) zenginleştirilmemiş (ancak nemlendirilen ve probiyotik uygulanan) deri mikrobiyota topluluklarının transferinin (hDmT) uygulanabilirliğini inceledi. Uyuz tanısı konulan ve yoğun kaşıntısı bulunan sahipli (aynı hasta sahibine ait olan), melez ırkı 2 köpek çalışmaya dahil edildi.
Nivea t bölgesi burun bantları, başka donör bir köpeğin görünüşte sağlıklı toplamda 3 farklı integümenter dokusuna yapıştırıldı ve 10-12 dakika kurumaya bırakıldı. Akabinde bantlar alınarak her 3 bant izotonik ile irrige edilen hasta deri dokusuna (her iki uyuzlu köpekte ayrı ayrı laterolateral bölgelere) yapıştırıldı en az 12-15 dakika yapışmasına izin verildi. Sonunda 3 bantta uzaklaştırıldı. Vas prurtius skorları, hem vaka I hem de II'de, 0. günden (hDmT başlangıç günü) 21. güne kadar önemli ölçüde azaldı. hDmT’den önce [-14. –(0.) günler] Vas kaşıntı skoru vaka I’ de 8-10, vaka II’ de 7-9 arasında değişmekteydi. hDmT’den önce, deri kazıntıları -14 ila 0. günlerde pozitif iken, hDmT’nin 2. gününden sonra, her iki köpekte çalışmanın sonuna kadar negatif elde edildi. Zenginleştirilmemiş deri mikrobiyotasının sağlıklı bir donörden hasta uyuzlu köpeklere aktarılmasının, deri mikroekolojisinin manipülasyonu ile klinik ve parazitolojik iyileşmeyi hızlandırmış olması gerektiği gibi bir ön yargıya varmak yanlış olmayacaktır.

Keywords

Köpek, mikrobiyom manuplasyonu, mikrobiyom modülasyonu, deri mikrobiyom transferi, Dog, Microbiome manuplation, Microbiome modulation, Skin Microbiota Transplantation

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