Clinical Use of Anti-Mullerian Hormone in Female Cats and Dogs
Year 2021,
Volume: 2 Issue: 2, 57 - 61, 31.12.2021
Semra Kaya
,
Gizem Akın
,
Gökhan Koçak
,
Cihan Kaçar
Abstract
Anti-Mullerian hormone (AMH) is a glycoprotein hormone which is produced by ovaries, after the development of the Mullerian duct that gives rise to female reproductive organs such as the vagina, uterus and oviduct. The AMH is detected at measurable concentrations in the peripheral blood samples of adult queens and bitches. In recent studies has been indicated that the use of AMH analysis in clinical examinations has contributed to reproductive endocrinology. The AMH which is produced by only granulosa cells of the ovary, is facilitated the diagnosis of many physiological and pathological conditions of queens and bitches. In the current review, a recent information about the factors affecting the AMH concentrations and the clinical indication of AMH are presented.
References
- 1. Akbarinejad V, Gharagozlou F, Vojgani M, Ranji A. Evidence for quadratic association between serum anti-Müllerian hormone (AMH) concentration and fertility in dairy cows. Animal Reproduction Science 2020; 218: 106457. doi: doi.org/10.1016/j.anireprosci.2020.106457.
- 2. Kereilwe O, Kadokawa H. Anti-Müllerian hormone and its receptor are detected in most gonadotropin-releasing-hormone cell bodies and fibers in heifer brains. Domestic Animal Endocrinology 2020; 72: 106432. doi: doi.org/10.1016/j.domaniend.2019.106432.
- 3. Mossa F, Jimenez-Krassel F, Scheetz D, Weber-Nielsen M, Evans ACO, et al. Anti-Müllerian hormone (AMH) and fertility management in agricultural species. Reproduction 2017; 154: R1-R11. doi: 10.1530/REP-17-0104.
- 4. Jost A. The age factor in the castration of male rabbit fetuses. Proceedings of the Society for Experimental Biology and Medicine 1947; 66: 302-303.
- 5. Themmen APN, Kalra B, Visser JA, Kumar A, Savjani G, et al. The use of anti-Müllerian hormone as diagnostic for gonadectomy status in dogs. Theriogenology 2016; 86: 1467-1474. doi: http://dx.doi.org/10.1016/j.theriogenology.2016.05.004.
- 6. Holst BS. Diagnostic possibilities from a serum sample-Clinical value of new methods within small animal reproduction, with focus on anti-Müllerian hormone. Reproductin Domestic Animals 2017; 52 (Suppl.2): 303-309. doi: 10.1111/rda.12856.
- 7. Yagci IP, Pekcan M, Polat IM, Kalender H, Macun HC. Does serum anti-Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits. Reproduction Domestic Animals 2016; 51: 910-915. doi: 10.1111/rda.12757.
- 8. Place NJ, Hansen BS, Cheraskin JL, Cudney SE, Flanders JA, et al. Measurement of serum anti-Müllerian hormone concentration in female dogs and cats before and after ovariohysterectomy. Journal of Veterinary Diagnostic Investigation 2011; 23: 524-527. doi: 10.1177/1040638711403428.
- 9. Songsasen N, Fickes A, Pukazhenthi BS, Wildt DE. Follicular morphology, oocyte diameter and localisation of fibroblast growth factors in the domestic dog ovary. Reproduction Domestic Animals 2009; 44 (Suppl.2): 65-70. doi: 10.1111/j.1439-0531.2009.01424.x.
- 10. Hollinshead FK, Walker C, Hanlon DW. Determination of the normal reference interval for anti-Müllerian hormone (AMH) in bitches and use of AMH as a potential predictor of litter size. Reproduction Domestic Animals 2016; 51 (Suppl.3): 1-6. doi: 10.1111/rda.12822.
- 11. Snoeck F, Sarrazin S, Wydooghe E, Soom AV. Age and anti-Müllerian hormone levels predict the success of in vitro maturation of cat oocytes. Reproduction Domestic Animals 2017; 52 (Suppl.2): 98-102. doi: 10.1111/rda.12827.
- 12. Walter B. Anti-Müllerian hormone in dogs and cats reproduction. Reproduction Domestic Animals 2020; 55 (Suppl. 2):26–31. doi: 10.1111/rda.13603.
- 13. Hollinshead FK, Walker C, Hanlon DW. Determination of the normal reference interval for anti-Müllerian hormone (AMH) in bitches and use of AMH as a potential predictor of litter size. Reproduction Domestic Animals 2017; 52 (Suppl.2): 35-40. doi: 10.1111/rda.12822.
- 14. Korkmaz Ö, Korkmaz D, Polat İM, Yağcı İP, Pekcan M, et al. Differences in the follicular morphology of young and aged bitches and their correlation with the anti-müllerian hormone. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2016; 22: 733-739. doi: 10.9775/kvfd.2016.15306.
- 15. Alkan KK, Ceylan A, Alkan H, Ozen D, Bayraktaroglu AG, et al. Immunohistochemical and qPCR determination of the expression and serum level of anti‐Müllerian hormone in pre‐pubertal, intact and ovarian remnant syndrome detected bitches. Reproduction Domestic Animals 2019; 54: 979-986. doi: 10.1111/rda.13451.
- 16. Yağcı İP, Polat İM, Pekcan M. Evaluation of age releated anti-Müllerian hormone variations in domestic cat. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2016; 22: 729-732. doi: 10.9775/kvfd.2016.15288.
- 17. Walter B, Feulner H, Otzdorff C, Klein R, Reese S, et al. Changes in anti-Müllerian hormone concentrations in bitches throughout the oestrous cycle. Theriogenology 2019; 127: 114-119. doi: https://doi.org/10.1016/j.theriogenology.2019.01.007.
- 18. Anadol E, Gultiken N, Yarim GF, Karaca E, Kanca H, et al. Investigation of diagnostic use of serum anti-Müllerian hormone concentration in dioestrus and anoestrus bitches before and after ovariohysterectomy and the relationship with ovarian follicle numbers. Polish Journal of Veterinary Sciences 2020; 23: 391-397. doi: 10.24425/pjvs.2020.134683.
- 19. Nagashima JB, Hansen BS, Songsasen N, Travis AJ, Place NJ. Anti-Mullerian hormone in the domestic dog during the anestrus to oestrous transition. Reproduction Domestic Animals 2016; 51: 158-164. doi: 10.1111/rda.12660.
- 20. Yilmaz ÖT, Toydemir TSF, Kirsan İ, Ucmak ZG, Karacam EC. Anti-Müllerian hormone as a diagnostict tool for ovarian remnant sydrome in bitches. Veterinary Research Communications 2015; 39: 159-162. doi: 10.1007/s11259-015-9639-0.
- 21. Alm H, Holst BS. Identifying ovarian tissue in the bitch using anti-Müllerian hormone (AMH) or luteinizing hormone (LH). Theriogenology 2018; 106: 15-20. doi: doi.org/10.1016/j.theriogenology.2017.09.028.
- 22. Axnér E, Holst BS. Concentrations of anti-Müllerian hormone in the domestic cat. Relation with spay or neuter status and serum estradiol. Theriogenology 2015; 83: 817-821. doi: doi.org/10.1016/j.theriogenology.2014.11.016.
23. Heaps LA, Scudder CJ, Lipscomb VJ, Steinbach SML, Priestnall SL, et al. Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat. Journal of Feline Medicine and Surgery Open Reports 2017; 3 (2): 1-5. doi: 10.1177/2055116917722701.
- 24. Walter B, Coelfen A, Jäger K, Reese S, Meyer-Lindenberg A, et al. Anti-Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts. Reproduction Domestic Animals 2018; 53: 784-792. doi: 10.1111/rda.13171.
- 25. Gharagozlou F, Youssefi R, Akbarinejad V, Sasani F, Taghizadeh-Jahed M, et al. Evaluation of serum anti-Müllerian hormone (AMH) in a Persian queen cat with bilateral cystic ovarian disease. Comparative Clinical Pathology 2014; 23: 237-239. doi: 10.1007/s00580-013-1822-5.
Anti-Müllerian Hormonun Dişi Kedi ve Köpeklerde Klinik Kullanımı
Year 2021,
Volume: 2 Issue: 2, 57 - 61, 31.12.2021
Semra Kaya
,
Gizem Akın
,
Gökhan Koçak
,
Cihan Kaçar
Abstract
Anti-Müllerian hormon (AMH) dişilerde vajina, uterus ve oviduktu içeren Müller kanalının gelişiminden sonra ovaryumlarda üretilen glikoprotein yapıda bir hormondur. Yetişkin kedi ve köpeklerde periferal dolaşımda ölçülebilecek düzeye ulaşmaktadır. Son yıllarda yapılan çalışmalarda, AMH analizinin klinik muayenelerde kullanılmasının reprodüktif endokrinolojiye katkı sağladığı ortaya konulmuş durumdadır. Anti-Müllerian hormon dişi kedi ve köpeklerde yalnızca ovaryumun granuloza hücrelerinde üretilmesi nedeniyle, bu organın pek çok fizyolojik ve patolojik durumunun teşhisine olanak sağlar. Sunulan derlemede dişi kedi ve köpeklerde AMH düzeyine etki eden faktörler ve klinik endikasyonları hakkında en son bilgiler aktarılmaktadır.
References
- 1. Akbarinejad V, Gharagozlou F, Vojgani M, Ranji A. Evidence for quadratic association between serum anti-Müllerian hormone (AMH) concentration and fertility in dairy cows. Animal Reproduction Science 2020; 218: 106457. doi: doi.org/10.1016/j.anireprosci.2020.106457.
- 2. Kereilwe O, Kadokawa H. Anti-Müllerian hormone and its receptor are detected in most gonadotropin-releasing-hormone cell bodies and fibers in heifer brains. Domestic Animal Endocrinology 2020; 72: 106432. doi: doi.org/10.1016/j.domaniend.2019.106432.
- 3. Mossa F, Jimenez-Krassel F, Scheetz D, Weber-Nielsen M, Evans ACO, et al. Anti-Müllerian hormone (AMH) and fertility management in agricultural species. Reproduction 2017; 154: R1-R11. doi: 10.1530/REP-17-0104.
- 4. Jost A. The age factor in the castration of male rabbit fetuses. Proceedings of the Society for Experimental Biology and Medicine 1947; 66: 302-303.
- 5. Themmen APN, Kalra B, Visser JA, Kumar A, Savjani G, et al. The use of anti-Müllerian hormone as diagnostic for gonadectomy status in dogs. Theriogenology 2016; 86: 1467-1474. doi: http://dx.doi.org/10.1016/j.theriogenology.2016.05.004.
- 6. Holst BS. Diagnostic possibilities from a serum sample-Clinical value of new methods within small animal reproduction, with focus on anti-Müllerian hormone. Reproductin Domestic Animals 2017; 52 (Suppl.2): 303-309. doi: 10.1111/rda.12856.
- 7. Yagci IP, Pekcan M, Polat IM, Kalender H, Macun HC. Does serum anti-Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits. Reproduction Domestic Animals 2016; 51: 910-915. doi: 10.1111/rda.12757.
- 8. Place NJ, Hansen BS, Cheraskin JL, Cudney SE, Flanders JA, et al. Measurement of serum anti-Müllerian hormone concentration in female dogs and cats before and after ovariohysterectomy. Journal of Veterinary Diagnostic Investigation 2011; 23: 524-527. doi: 10.1177/1040638711403428.
- 9. Songsasen N, Fickes A, Pukazhenthi BS, Wildt DE. Follicular morphology, oocyte diameter and localisation of fibroblast growth factors in the domestic dog ovary. Reproduction Domestic Animals 2009; 44 (Suppl.2): 65-70. doi: 10.1111/j.1439-0531.2009.01424.x.
- 10. Hollinshead FK, Walker C, Hanlon DW. Determination of the normal reference interval for anti-Müllerian hormone (AMH) in bitches and use of AMH as a potential predictor of litter size. Reproduction Domestic Animals 2016; 51 (Suppl.3): 1-6. doi: 10.1111/rda.12822.
- 11. Snoeck F, Sarrazin S, Wydooghe E, Soom AV. Age and anti-Müllerian hormone levels predict the success of in vitro maturation of cat oocytes. Reproduction Domestic Animals 2017; 52 (Suppl.2): 98-102. doi: 10.1111/rda.12827.
- 12. Walter B. Anti-Müllerian hormone in dogs and cats reproduction. Reproduction Domestic Animals 2020; 55 (Suppl. 2):26–31. doi: 10.1111/rda.13603.
- 13. Hollinshead FK, Walker C, Hanlon DW. Determination of the normal reference interval for anti-Müllerian hormone (AMH) in bitches and use of AMH as a potential predictor of litter size. Reproduction Domestic Animals 2017; 52 (Suppl.2): 35-40. doi: 10.1111/rda.12822.
- 14. Korkmaz Ö, Korkmaz D, Polat İM, Yağcı İP, Pekcan M, et al. Differences in the follicular morphology of young and aged bitches and their correlation with the anti-müllerian hormone. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2016; 22: 733-739. doi: 10.9775/kvfd.2016.15306.
- 15. Alkan KK, Ceylan A, Alkan H, Ozen D, Bayraktaroglu AG, et al. Immunohistochemical and qPCR determination of the expression and serum level of anti‐Müllerian hormone in pre‐pubertal, intact and ovarian remnant syndrome detected bitches. Reproduction Domestic Animals 2019; 54: 979-986. doi: 10.1111/rda.13451.
- 16. Yağcı İP, Polat İM, Pekcan M. Evaluation of age releated anti-Müllerian hormone variations in domestic cat. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2016; 22: 729-732. doi: 10.9775/kvfd.2016.15288.
- 17. Walter B, Feulner H, Otzdorff C, Klein R, Reese S, et al. Changes in anti-Müllerian hormone concentrations in bitches throughout the oestrous cycle. Theriogenology 2019; 127: 114-119. doi: https://doi.org/10.1016/j.theriogenology.2019.01.007.
- 18. Anadol E, Gultiken N, Yarim GF, Karaca E, Kanca H, et al. Investigation of diagnostic use of serum anti-Müllerian hormone concentration in dioestrus and anoestrus bitches before and after ovariohysterectomy and the relationship with ovarian follicle numbers. Polish Journal of Veterinary Sciences 2020; 23: 391-397. doi: 10.24425/pjvs.2020.134683.
- 19. Nagashima JB, Hansen BS, Songsasen N, Travis AJ, Place NJ. Anti-Mullerian hormone in the domestic dog during the anestrus to oestrous transition. Reproduction Domestic Animals 2016; 51: 158-164. doi: 10.1111/rda.12660.
- 20. Yilmaz ÖT, Toydemir TSF, Kirsan İ, Ucmak ZG, Karacam EC. Anti-Müllerian hormone as a diagnostict tool for ovarian remnant sydrome in bitches. Veterinary Research Communications 2015; 39: 159-162. doi: 10.1007/s11259-015-9639-0.
- 21. Alm H, Holst BS. Identifying ovarian tissue in the bitch using anti-Müllerian hormone (AMH) or luteinizing hormone (LH). Theriogenology 2018; 106: 15-20. doi: doi.org/10.1016/j.theriogenology.2017.09.028.
- 22. Axnér E, Holst BS. Concentrations of anti-Müllerian hormone in the domestic cat. Relation with spay or neuter status and serum estradiol. Theriogenology 2015; 83: 817-821. doi: doi.org/10.1016/j.theriogenology.2014.11.016.
23. Heaps LA, Scudder CJ, Lipscomb VJ, Steinbach SML, Priestnall SL, et al. Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat. Journal of Feline Medicine and Surgery Open Reports 2017; 3 (2): 1-5. doi: 10.1177/2055116917722701.
- 24. Walter B, Coelfen A, Jäger K, Reese S, Meyer-Lindenberg A, et al. Anti-Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts. Reproduction Domestic Animals 2018; 53: 784-792. doi: 10.1111/rda.13171.
- 25. Gharagozlou F, Youssefi R, Akbarinejad V, Sasani F, Taghizadeh-Jahed M, et al. Evaluation of serum anti-Müllerian hormone (AMH) in a Persian queen cat with bilateral cystic ovarian disease. Comparative Clinical Pathology 2014; 23: 237-239. doi: 10.1007/s00580-013-1822-5.