Polycystic Liver Disease in a Golden Syrian Hamster

Year 2020, Volume: 1 Issue: 1-2, 34 - 38, 15.12.2020

Erdem Gülersoy , Mehmet Maden Büşra Burcu Erol , Nimet İsmailoğlu Kurtuluş Parlak

Abstract

Polycystic liver disease (PLD) has been reported in humans, dogs, cats, hamsters, rats, deer and some farm animals such as goats and pigs. PLD is observed in hamsters over 1 year old and is similar to congenital polycystic disease in humans. The material of the present case was consisted of 2-year-old, male, Golden Syrian hamster. Physical examination revealed enophthalmos, rapid breathing and bilateral abdominal distension. Ascites and intraabdominal fluctuant structures in the cranial abdominal region were detected. In the ultrasonographic examination, anechogenous and multiple cystic structures were detected in the liver. In serum biochemistry, hyperbilirubinemia and hypoalbuminemia were determined. In microscopic examination of cyst fluid, large quantities of eosinophilic materials were remarkable. As a result, the hamster with anorexia and abdominal distension complaints; PLD, which is generally asymptomatic and incidental is diagnosed based on clinical, ultrasonographic and cytological findings. It was determined that transabdominal ultrasonographic examination is useful in the diagnosis of PLD cases, ultrasound-guided cystic and peritoneal fluid aspiration contributes significantly to the diagnosis. As the interest in hamster care has been increasing day by day it is considered that the present case will provide useful information in veterinary practice on the clinical symptoms and diagnosis of PLD disease.

Keywords

Hepatocellular disease, Polycystic liver disease, Syrian hamster, Ultrasound

References

• 1. Renshaw HW, Van Hoosier GL, Amend NK. A Survey of Naturally Occurring Diseases of the Syrian Hamster. Lab Animals 1975; 9: 179-191.
• 2. Goodman FR. Negative inotropic effects of gentamicin in guinea-pig left atria. Federation proceedings 1976; 35: 613.
• 3. Battles AH. The biology, care and disease of the Syrian hamster. Continuing Education 1985; 7: 815-825.
• 4. Reavill DR. The Pathology of Common Diseases in Small Exotic Mammals. C.L. Davis Foundation Pre-Meeting Workshop. November, 2004; Orlando-USA.
• 5. Handler AH. Spontaneous lesions of the hamster. In: The Pathology of Laboratory Animals 1965; 97: 210-240.
• 6. Somvanshi R, Iyer PKR, Biswas JC, Koul GL. Polycystic Liver Disease in Golden Hamsters. Journal of Comparative Pathology 1987; 97: 615-618.
• 7. Van den Ingh TS, Rothuizen J. Congenital cystic disease of the liver in seven dogs. Journal of Comparative Pathology 1985; 95: 405-414.
• 8. Mckenna SC, Carpente JL. Polycystic Disease of the Kidney and Liver in the Cairn Terrier. Veterinary Pathology 1980; 17: 436-442.
• 9. Stebbins KE. Polycystic Disease of the Kidney and Liver in an Adult Persian Cat. Journal of Comparative Pathology 1989; 100: 327-330.
• 10. Glawischnig W, Bago Z. Polycystic Liver Disease in Senile Chamois (Rupicaprae rupicaprae). Journal of Wildlife Disease 2010; 46: 669–672.
• 11. Lager DJ, Qian Q, Bengal RJ, Ishibashi M, Torres VE. The pck rat: A new model that resembles human autosomal dominant polycystic kidney and liver disease. Kidney International 2001; 59: 126–136.
• 12. Ikeda K, Saito M. Inhibitory effect of rose hip (Rosa canina L.) on melanogenesis in mouse melanoma cells and on pigmentation in brown guinea pigs. Bioscience, Biotechnology, and Biochemistry 2011; 75: 489-495.
• 13. Van Aerts RM, Van de Laarschot LF, Banales JM, Drenth JP. Clinical management of polycystic liver disease. Journal of Hepatology 2018; 68: 827-837.
• 14. Kanimozhi V, Palanivel K, Akbarsha MA, Kadalmani B. Tributyltin mediated hepatic, renal and testicular tissue damage in male Syrian hamster (Mesocricetus auratus): a study on impact of oxidative stress. Springerplus 2016; 5: 1523.
• 15. Brunnert SR, Altman NH. Laboratory assessment of chronic hepatitis in Syrian hamsters. Laboratory Animal Science 1991; 41: 559-562.
• 16. Zimmerman KL, Moore DM, Smith SA. Hematology of laboratory rabbits (Oryctolagus cuniculus). In: Weiss DJ, Wardrop KJ. eds. In: Schalm’s Veterinary Hematology. Wiley-Blackwell Ames, 2010; pp. 862–869.
• 17. Sidebotham D. Nutrition and Disorders of Gastrointestinal and Hepatic Function. Cardiothoracic Critical Care 2007; 34: 495-509.
• 18. Borini PB, Guimaraes RC. Indicators Of Inflammation And Cellular Damage In: Chronic Asymptomatic Or Oligosymptomatic Alcoholics: Correlation With Alteration Of Bilirubin And Hepatic And Pancreatic Enzymes. Revista do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo 1999; 54: 53-60.
• 19. Everson GT, Scherzinger A, Berger-Leff N. Polycystic liver disease: quantitation of parenchymal and cyst volumes from computed tomography images and clinical correlates of hepatic cysts. Hepatology 1988; 8: 1627–1634.
• 20. Baker R, Lumsden JH. Cytopathology techniques and interpretation. In: Baker R, Lumsden J. eds. In: Color Atlas of the Dog and Cat St. Louis. Mosby, 2000; pp. 941-943.
• 21. Chandler DB, Barton JC, Briggs DD, Butler TWJ, Kennedy IW et al. Effect of iron deficiency on bleomycin-induced lung fibrosis in the hamster. The American Review of Respiratory Disease 1988; 137: 85–89.
• 22. Patterson M, Juan C, Gonzalez-Vitale, Charles JF. Polycystic Liver Disease: A Study Of Cyst Fluid Constituents. Hepatology 1982; 2: 475-478.
• 23. Plengsuriyakarn T, Eursitthichai F, Labbunruang N, Na-Bangchang K, Tesana S et al. Ultrasonography as a Tool for Monitoring the Development and Progression of CholangiocarcinomainOpisthorchisviverrini/Dimethylnitrosamine-Induced Hamsters. Asian Pacific Journal of Cancer Prevention 2012; 12: 87-90.
• 24. Paul-Murphy J, Ramer J. Urgent care of the pet rabbit. Veterinary Clinics of North America Exotic Animal Practice 1998; 1: 127-152.