Medikal Ozonun Deri Lezyonlarının İyileşmesi Üzerine Etkileri

Year 2022, Volume: 3 Issue: 2, 57 - 61, 30.12.2022

Nevzat Emre Aslan , Hanifi Erol

Abstract

Fiziksel, kimyasal ve bakteriyel ajanlara karşı bariyer görevi gören deri yaralanmasına bağlı olarak; kaybolan fonksiyonlarını eski haline getirmek ve dokularını onarabilme yeteneğinin yanı sıra yara iyileşmesinde de belirli basamaklardan oluşan bir mekanizmayı içermektedir. Deride yara oluşumunun hemen ardından başlayan hemostazis evresini takiben 2-5 gün boyunca devam eden inflamasyon evresi ve daha sonra proliferasyon evresi başlamaktadır. Bu süreçte anjiyogenezis, granülasyon doku oluşumu, kollajen birikimi ve epitelizasyon birlikte görülmektedir. Yara iyileşmesinin son evresi ise maturasyon ve remodelling evresidir. Ozon mikroorganizmaların yok olmasına ve iyileşme sürecinin uyarılmasını sağlayan güçlü bir oksitleyicidir. Bakteri, mantar ve virüs enfeksiyonlarına karşı immun sistemi aktive etmektedir. Antipatojenik etki gösteren, arteriyollerin vazodilatasyonunu sağlayarak oksijenlenmeyi artıran ozon; basınç altındaki oksijenin dokulara yayılarak anaerobik bakteri üremesi engeller. Epitelizasyon sürecinde matriks birikimi ve hücre çoğalmasını artıran ozon, yara iyileşmesinde daha az inflamatuar hücre ve daha çok miyofibroblast içeren granülasyon dokusu oluşturmaktadır. Ayrıca toksinleri uzaklaştırarak, besin ve immünolojik faktörler açısından iyileşme sürecine destek sağlamaktadır.

Keywords

Ozon, Deri, Yara, İyileşme mekanizması, Ozone, Skin, Wound, Mechanism of healing

Effects of Medical Ozone on Healing of Skin Lesions

Abstract

Depending on the skin injury, which acts as a barrier against physical, chemical and bacterial agents; It includes a mechanism consisting of certain steps in wound healing, as well as the ability to restore last functions and repair tissues. Following the hemostasis phase, which starts right after the wound formation on the skin, the inflammation phase continues for 2-5 days and then the proliferation phase begins. In this process, angiogenesis, granulation tissue formation, collagen deposition and epithelialization are seen together. The final phase of wound healing is the maturation and remodelling phase. Ozone is a powerful oxidizer that destroys microorganisms and stimulates the healing process. It activates the immun system against bacterial, fungal and viral infections. Ozone, which has an antipathogenic effect and increases oxygenation by providing vasodilation of arterioles; Oxygen under pressure spreads to the tissues and prevents anaerobic bacteria growth. Ozone, which increases matrix accumulation and cell proliferation in the epithelialization process, creates granulation tissue containing less inflammatory cells and more miyofibroblasts in wound healing. It also supports the healing process in terms of nutrients and immunological factors by removing toxins.

Keywords

Ozone, Skin, Wound, Mechanism of healing, Deri, Yara, İyileşme Mekanizması, Ozon

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