Canine Papillamatozisde Bleomisinin Klinik Etkinliği: İki Yavru Kardeş Köpeğin Olgu Sunumu

Year 2024, Volume: 5 Issue: 1, 18 - 22, 28.06.2024

Songül Erdoğan , Gözde Ak , Hasan Erdoğan , Kerem Ural

https://doi.org/10.58833/bozokvetsci.1425583

Abstract

Amaç: Amaç anti-tümoral bleomisinin iki erkek, Pug ırkı yavru kardeş köpekde canine papillamatozis (CP) üzerine klinik etkinliğinin değerlendirilmesidir.
Materyal ve Yöntem: İki tane 8 aylık yaşta, erkek yavru kardeş köpek ağız ve çene bölgesinde birden fazla siğil lezyonu ile başvuruda bulundu. Şüpheli canine papillamatozis tanısı yalnızca tipik karnıbahar benzeri siğil görüntüsünü içeren klinik bulgular ile konuldu. Her iki kardeşte bleomisin haftalık 0.5 IU/kg dozda deri altı yolla uygulandı.
Bulgular: 6. haftada kardeşlerden birinde oral lezyonlar tamamen kaybolurken diğer kardeşte tam iyileşme 9. haftada sağlandı. Siğiller yeni lezyon olmaksızın kalıcı olarak tamamen çözüldü. Haftalık kan sayımı ve fiziksel muayene bulgularıyla takip yapıldı ve tedavi süresince ve sonrasında hiçbir yan etki görülmedi.
Sonuç: Deri altı yolla 0.5 IU/kg dozda haftalık uygulanan köpeklerde oral lezyonların gerilemesine ve klinik sonuçların iyileşmesine katkıda bulunması bleomisinin CP tedavisinde potansiyel etkinliğini desteklemektedir.
Anahtar Kelimeler: bleomisin, oral lezyon, papilloma, siğiller.

Keywords

bleomisin, oral lezyon, papilloma, siğiller

Ethical Statement

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Supporting Institution

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Thanks

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Clinical Efficacy of Bleomycin in Canine Papillomatosis: Case Report of Two Sibling Puppies

Abstract

Aim: The objective was to assess the clinical efficacy of anti-tumoral bleomycin on canine papillomatosis (CP) in two male Pug breed sibling puppies.
Material and Methods: Two 8 month-old, male sibling puppies were presented with multiple warts in the lip and chin. A suspected diagnosis of CP was established through only clinical examination with appearance of typical cauliflower-like warts. Bleomycin was subcutaneously administered to both siblings on a weekly by 0.5 IU/kg dosage.
Results: At week 6, one of the siblings exhibited complete regression of oral lesions, whereas the other sibling achieved complete healing by week 9. The warts persistently show complete resolution, with no new lesions. No adverse effects were observed, verified through weekly blood count and physical examination during and post-treatment.
Conclusion: Subcutaneous administration of bleomycin at weekly at a dose of 0.5 IU/kg contributed to the regression of oral lesions and improved clinical outcomes in dogs, suggesting potential efficiency in the treatment of CP.

Keywords

bleomycin, oral lesion, papilloma, warts

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