Doğal Öldürücü Hücre Aktivitesinde İmmunomodulatör Etki Gösteren Moleküller

Year 2022, Volume: 5 Issue: 2, 312 - 317, 01.05.2022

Hüseyin Kaya , Seda Kuşoğlu Gültekin , Belkis Atasever Arslan

https://doi.org/10.19127/bshealthscience.1009193

Abstract

Doğal Öldürücü (NK) hücreleri viral enfeksiyonlara karşı savunmadan ve malignant hücrelerin elimine edilmesinden sorumludur. NK aktivitesi, aktivatör ve inhibitör etkiye sahip yüzey reseptörleri, sitokinlerin etkisi ve diğer immun hücrelerle yaptıkları etkileşimler tarafından düzenlenir. Kanser immünoterapi stratejilerinde, T hücreleri, NK hücreler, NK-T hücreleri, B hücreleri, dendritik hücreler ve makrofajların kanser hücrelerini tanıma ve elimine etme özelliklerinden yararlanılması amaçlanır. Doğal öldürücü hücre reseptörleri, NK hücresi aktivasyonunu ve homeostazını düzenlemeden sorumludurlar. Bu reseptörlerden iletilen aktive edici ve inhibitör sinyaller arasındaki denge NK hücre işlevselliğini kontrol eder. Aktivatör reseptörler, sitotoksisite reseptörlerini (NCRs) (NKp46, NKp30 ve NKp44) ve CD94/NKG2C, NKG2D, NKG2E/H ve NKG2F reseptörlerini içerir. İnhibitör reseptörler arasında C-tipi lektin reseptörleri (CD94 / NKG2A / B) ve KIR reseptörleri (KIR-2DL ve KIR-3DL) bulunur. Derlemede NK hücrelerinin etki mekanizmaları ve NK hücre aktivitesine immunomodülatör etki gösteren moleküller ele alınmıştır .

Keywords

Anti-tümör, İmmünoterapi, NK hücreleri

Molecules That Show Immunomodulator Effect on Natural Killer Cell Activity

Abstract

Natural Killer (NK) cells are responsible for defending against viral infections and eliminating malignant cells. NK activity is regulated by surface receptors with activating and inhibitory effects, the action of cytokines, and their interactions with other immune cells. Cancer immunotherapy strategies aim to benefit from the ability of T cells, NK cells, NK-T cells, B cells, dendritic cells and macrophages to recognize and eliminate cancer cells. Natural killer cell receptors are responsible for regulating NK cell activation and homeostasis. The balance between activating and inhibitory signals transmitted from these receptors controls NK cell functionality. Activator receptors include cytotoxicity receptors (NCRs) (NKp46, NKp30 and NKp44) and CD94/NKG2C, NKG2D, NKG2E/H and NKG2F receptors. Inhibitory receptors include C-type lectin receptors (CD94 / NKG2A / B) and KIR receptors (KIR-2DL and KIR-3DL). In this review, the mechanisms of action of NK cells and molecules that have immunomodulatory effects on NK cell activity are discussed.

Keywords

Anti-tumor, Immunotherapy, NK cells

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