Abstract
Introduction:
Subclinical hyperthyroidsm is associated with negative effects on
cardiovascular system. We aimed to evaluate the association between
pre-operative thyroid hormones and post-operative outcome in patients
undergoing coronary artery by-pass graft (CABG) surgery.
Methods:
A hundred and eighty nine patients with isolated CABG surgery were
included into the study. Patient’s clinical characteristics,
surgical details and post-operative mortality and morbidities were
recorded.Patients were divided into two groups according to their TSH
level with cut-off point of 0,35 was assumed.
Results:
The first group consists of 16 patients (9%) with subclinical
hyperthyroid (SH) and the second group includes 173 euthyroid
patients. In post-operative period; the incidence of arrhythmia,
renal failure and inotropy requirement were significantly higher in
SH group (p<.0001, p: 0.0002 and p<.0001 respectively)
The incidence of
peri-operative mortality was similar between groups. (p: 0.0860).
Lenght of stay in
intesive care unit and overall were significantly higher in patients
with SH (p:
0.0102
and p: 0.0004 respectively).
Discussion and
Conclusion:
Pre-operative subclinical hyperthyroidsm didn’t effect
peri-operative mortality but may lead to higher postoperative
complications such as arrhythmia, renal failure and low cardiacoutput
syndrome in patients undergoing CABG surgery.
References
- Referans1- Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet. 2001; 358(9285):861–865.Referans 2-Iervasi G Pingitore A, Landi P, Racitii M, Ripoli A, Scariattini M, L’Abbate A, Donato L.Low-T3 syndrome:a strong progostic predictor of death in patients with herat disease. Circulation. 2003, 11;107(5):708–13. Referans 3- Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008; 29(1):76–131Referans 4-Park, Y.J., Yoon, J.W., Kim, K.I. et al. Subclinical hypothyroidism might increase the risk of transient atrial fibrillation after coronary artery bypass grafting. Ann Thorac Surg. 2009; 87: 1846–1852Referans 5- Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2):228–238.Referans 6- Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet. 2001; 358(9285):861–865.Referans 7- Sawin CT, Geller A, Wolf PA, et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med. 1994; 331(19):1249–1252.Referans 8- Kaptein EM. Thyroid function in renal failure. Contrib Nephrol. 1986;50:64–72Referans 9- Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001. February 15; 344 7: 501– 9Referans 10-Chu SH, Huang TS, Wang SS, Wang CJ. Thyroid hormon changes after cardiovascular surgery and clinical implications. Ann Thorac Surg 1991;52:791-6
Abstract
Introduction:
Subclinical hyperthyroidsm is associated with negative effects on
cardiovascular system. We aimed to evaluate the association between
pre-operative thyroid hormones and post-operative outcome in patients
undergoing coronary artery by-pass graft (CABG) surgery.
Methods:
A hundred and eighty nine patients with isolated CABG surgery were
included into the study. Patient’s clinical characteristics,
surgical details and post-operative mortality and morbidities were
recorded.Patients were divided into two groups according to their TSH
level with cut-off point of 0,35 was assumed.
Results:
The first group consists of 16 patients (9%) with subclinical
hyperthyroid (SH) and the second group includes 173 euthyroid
patients. In post-operative period; the incidence of arrhythmia,
renal failure and inotropy requirement were significantly higher in
SH group (p<.0001, p: 0.0002 and p<.0001 respectively)
The incidence of
peri-operative mortality was similar between groups. (p: 0.0860).
Lenght of stay in
intesive care unit and overall were significantly higher in patients
with SH (p:
0.0102
and p: 0.0004 respectively).
Discussion and
Conclusion:
Pre-operative subclinical hyperthyroidsm didn’t effect
peri-operative mortality but may lead to higher postoperative
complications such as arrhythmia, renal failure and low cardiacoutput
syndrome in patients undergoing CABG surgery.
References
- Referans1- Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet. 2001; 358(9285):861–865.Referans 2-Iervasi G Pingitore A, Landi P, Racitii M, Ripoli A, Scariattini M, L’Abbate A, Donato L.Low-T3 syndrome:a strong progostic predictor of death in patients with herat disease. Circulation. 2003, 11;107(5):708–13. Referans 3- Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008; 29(1):76–131Referans 4-Park, Y.J., Yoon, J.W., Kim, K.I. et al. Subclinical hypothyroidism might increase the risk of transient atrial fibrillation after coronary artery bypass grafting. Ann Thorac Surg. 2009; 87: 1846–1852Referans 5- Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2):228–238.Referans 6- Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet. 2001; 358(9285):861–865.Referans 7- Sawin CT, Geller A, Wolf PA, et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med. 1994; 331(19):1249–1252.Referans 8- Kaptein EM. Thyroid function in renal failure. Contrib Nephrol. 1986;50:64–72Referans 9- Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001. February 15; 344 7: 501– 9Referans 10-Chu SH, Huang TS, Wang SS, Wang CJ. Thyroid hormon changes after cardiovascular surgery and clinical implications. Ann Thorac Surg 1991;52:791-6
Details
| Primary Language | English |
|---|---|
| Journal Section | Araştırma Makalesi |
| Authors | |
| Publication Date | September 28, 2018 |
| Published in Issue | Year 2018 Volume: 5 Issue: 3 |
