Serebral Palside İskelet Kası ve Amino Asit Profilleri

Year 2024, Volume: 11 Issue: 2, 330 - 336, 28.06.2024

Sevde Nur Olgun , Emre Manisalı , Fatma Çelik

https://doi.org/10.34087/cbusbed.1296353

Abstract

Serebral palsi, kişinin hareket kabiliyetini, stabilitesini ve duruşunu etkileyen, günlük yaşam aktivitelerinde kısıtlamalara neden olan nörolojik bir hastalıktır. Dünya’da yaklaşık 2-2,5/1000 canlı doğumda görülen hastalık, progresif değildir ve prenatal, natal ve postnatal dönemlerde görülen risk faktörlerinden dolayı gelişmektedir. Klinik bulgular ve semptomlar genellikle 18-24 aylıkken ortaya çıkar ve hastanın vücudundaki tutulum, kas fonksiyonları, beceri ve kısıtlılıklara göre alt tiplere ayrılmaktadır. Birçok alt tipi bulunan serebral palsi hastalığı sonucu kas yapısında azalmış kas boyutu/kesit alanı, azalmış kontraktil doku/bağ dokusu, aşırı gerilmiş sarkomerler ve sarkomerik titin kaybı gibi farklılıklar görülmektedir. İskelet kası, enerjiyi proteinler şeklinde depolamakta ve bu nedenle proteinlerin yapı taşı olan amino asitler kas için önemli bir molekül haline gelmektedir. Serebral palsili bireylerin hem malnütrisyondan korunması hem de kas fonksiyonlarının düzenlenmesi için birçok çeşidi bulunan amino asitlerin araştırılması önem arz etmektedir. Bu derlemede serebral palside görülen iskelet kası değişiklikleri ve amino asit profillerinin iskelet kası üzerindeki etkilerini incelemek ve genel bir bakış açısı oluşturmak hedeflenmiştir.

Keywords

Amino asit, İskelet kası, Serebral palsi

Skeletal Muscle and Amino Acid Profiles in Cerebral Palsy

Abstract

Cerebral palsy is a neurological disease that affects a person's mobility, stability and postüre, causing restrictions on daily living activities. The disease, which occurs in approximately 2-2.5/1000 live births on Earth, is not progressive and develops due to risk factors seen during prenatal, natal and postnatal periods. Clinical findings and symptoms usually occur at 18-24 months of age and are divided into subtypes based on the eclipse, muscle function, skill and limitations in the patient's body. As a result of cerebral palsy, which has many subtypes, differences in muscle structure such as decreased muscle size/section area, decreased contractile tissue/connective tissue, overstretched sarcomeres and loss of sarcomeric titin are seen. Skeletal muscle stores energy in the form of proteins, and therefore amino acids, which are the building blocks of proteins, become an important molecule for muscle. It is important to investigate amino acids, which have many variants to protect cerebral palsy individuals from both malnutrition and regulate muscle function. This review aimed to examine the effects of skeletal muscle changes and amino acid profiles seen in cerebral palsy on skeletal muscle and to establish an overview.

Keywords

Amino acids, Skeletak muscle, Cerebral palsy

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