Neurotrophic factors and depression: pathophysiology and beyond

Year 2012, Volume: 2 Issue: 2, 53 - 56, 31.01.2014

Salih Gümrü Feyza Arıcıoğlu

Abstract

Although depression is one of major psychiatric disorders in society, its neurobiology remains still unclear. Since 1970’s, many hypotheses on depression have been discussed. In recent years, many new points of view have emerged in this research area. Major depression is associated with reduced volumes in the hippocampus and prefrontal cortex, and antidepressant drugs promote many forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation in hippocampus. Recent evidences indicate that neurotrophic factors may regulate neuronal plasticity bidirectionally, meaning they may play role in pathophysiology and treatment of depression.

Key words: neurotrophic factors, brain-derived neurotrophic factor (BDNF), plasticity, depression

Keywords

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Nörotrofik faktörler ve depresyon: Patofizyoloji ve ötesi

Abstract

Depresyon toplumda yaygın bir psikiyatrik bozukluk olmasına rağmen, patofizyolojisi henüz aydınlatılamamıştır. 1970’li yıllardan beri depresyon üzerine birçok hipotez tartışılmış; son yıllarda bu alanda birçok yeni görüş ortaya çıkmıştır. Majör depresyon hipokampus ve prefrontal kortekste hacim azalmalarıyla belirgindir ve antidepresan ilaçlar hipokampusta nörojenez, sinaptojenez ve nöronal matürasyon dahil nöronal plastisitenin pek çok çeşidini tetiklemektedir. Son yıllarda elde edilen bazı bulgular, nörotrofik faktörlerin nöronal plastisiteyi çift yönlü olarak düzenleyebildiğini göstermektedir. Bu durum, nörotrofik faktörlerin depresyonun hem patofizyolojisinde, hem de tedavisinde rol oynuyor olduğu şeklinde yorumlanabilir.

Anahtar Kelimeler : Nörotrofik faktörler, beyin-kaynaklı nörotrofik faktör (BDNF), plastisite, depresyon 

Keywords

Nörotrofik faktörler, beyin-kaynaklı nörotrofik faktör (BDNF), plastisite, depresyon

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