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The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study

Year 2022, Volume: 12 Issue: 3, 691 - 696, 28.09.2022
https://doi.org/10.33808/clinexphealthsci.1012775

Abstract

Objective: This study aims to reveal the effects of cyanoacrylate application at the recipient bed and the donor site in free gingival graft surgery on graft dimensions, clinical healing parameters and patient-based outcomes.
Methods: Free gingival graft operations were conducted on individuals who were randomly assigned to control or test groups. In the test group, the graft was stabilized and the donor site was coated with cyanoacrylate. In the control group, 6/0 polyvinylidene fluoride sutures were used for stabilization, while the donor site was left untreated. Variables including re-epithelization, post-operative complications, pain, bleeding and quality of life at recipient site, and color match, graft dimensions at donor site were assessed for up to 6 months.
Results: Twenty-three individuals completed the study. No differences were observed in any variable between groups except horizontal dimension loss of the graft, which was more abundant in the cyanoacrylate group at six months (p>0.05, p<0.05; respectively).
Conclusion: According to our results, cyanoacrylate can be used safely for free gingival graft surgery, but does not surpass conventional suturing with polyvinylidene fluoride.

Supporting Institution

This research did not receive any specific grant from funding agencies in the public, commercial, or not‐for‐profit sectors.

References

  • Zucchelli G, Mounssif I. Periodontal plastic surgery. Periodontol 2015;68(1):333-368.
  • Miller PD. Root coverage using a free soft tissue autograft following citric acid application. Part 1: Technique. Int J Periodontics Restorative Dent 1982;2(1):65-70.
  • Sullivan HC, Atkins JH. Free autogenous gingival grafts. I. Principles of successful grafting. Periodontics 1968;6(3):121-129.
  • Zucchelli G, Mounssif I, Mazzotti C, et al. Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial. J Clin Periodontol 2014;41(7):708-716.
  • Stavropoulou C, Atout RN, Brownlee M. A randomized clinical trial of cyanoacrylate tissue adhesives in donor site of connective tissue grafts. J Periodontol 2019;90(6):608-615.
  • Eaglstein WH, Sullivan T. Cyanoacrylates for skin closure. Dermatol Clin 2005;23(2):193 198.
  • Montanaro L, Arciola CR, Cenni E. Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use. Biomaterials 2000;22(1):59-66.
  • Miller GM, Dannenbaum R, Cohen DW. A Preliminary Histologic Study of the Wound Healing of Mucogingival Flaps When Secured With the Cyanoacrylate Tissue Adhesives. J Periodontol 1974;45(8.2):608-618.
  • Ghoreishian M, Gheisari R, Fayazi M. Tissue adhesive and suturing for closure of the surgical wound after removal of impacted mandibular third molars: A comparative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108(1):e14-16.
  • Petersen PE. The World Oral Health Report 2003: Continuous improvement of oral health in the 21st century – The approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol 2003;31Suppl 1:3-23.
  • Ng SKS, Leung WK. A community study on the relationship of dental anxiety with oral health status and oral health related quality of life. Community Dent Oral Epidemiol 2008;36(4):347-356.
  • Ozcelik O, Haytac MC, Seydaoglu G. Immediate post-operative effects of different periodontal treatment modalities on oral health-related quality of life: A randomized clinical trial. J Clin Periodontol 2007;34(9):788-796.
  • Holbrook T, Ochsenbein C. Complete coverage of the denuded root surface with a one-stage gingival graft. Int J Periodontics Restorative Dent 1983;3(3):8-27.
  • Gümüş P, Buduneli E. Graft stabilization with cyanoacrylate decreases shrinkage of free gingival grafts. Aust Dent J 2014;59(1):57-64.
  • Borie E, Rosas E, Kuramochi G. Oral Applications of cyanoacrylate adhesives: A literature review. BioMed Res Int 2019; Mar 17:8217602.
  • Toriumi DM, Raslan WF, Friedman M. Histotoxicity of Cyanoacrylate Tissue Adhesives: A Comparative Study. Arch Otolaryngol Neck Surg 1990;116(5):546-550.
  • Inal S, Yilmaz N, Nisbet C. Biochemical and histopathological findings of N-Butyl-2-Cyanoacrylate in oral surgery: an experimental study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Dec;102(6):e14-17.
  • Åslund M, Suvan J, Moles DR. Effects of Two different methods of non-surgical periodontal therapy on patient perception of pain and quality of life: A randomized controlled clinical trial. J Periodontol 2008;79(6):1031-1040.
  • Tavelli L, Asa’ad F, Acunzo R. Minimizing patient morbidity following palatal gingival harvesting: A randomized controlled clinical study. Int J Periodontics Restorative Dent 2018;38(6):e127-134.
  • Ozcan M, Ucak O, Alkaya B.Effects of platelet-rich fibrin on palatal wound healing after free gingival graft harvesting: A comparative randomized controlled clinical trial. Int J Periodontics Restorative Dent 2017;37(5):e270-278.
  • Parirokh M, Asgary S, Eghbal MJ.A scanning electron microscope study of plaque accumulation on silk and PVDF suture materials in oral mucosa. Int Endod J 2004;37(11):776-781.
  • Kakoei S, Baghaei F, Dabiri S.A comparative in vivo study of tissue reactions to four suturing materials. Iran Endod J 2010;5(2):69-73.
  • Tabanella G. Oral tissue reactions to suture materials: A review. J West Soc Periodontol Periodontal Abstr 2004;52(2):37-44.
  • Muglali M, Ylmaz N, Inal S. Immunohistochemical comparison of indermil with traditional suture materials in dental surgery. J Craniofac Surg 2011;22(5):1875-1879.
  • Kumar MS, Natta S, Shankar G.Comparison between silk sutures and cyanoacrylate adhesive in human mucosa: A clinical and histological study. J Int Oral Health 2013 Oct;5(5):95-100.
  • Camacho-Alonso F, López-Jornet P, Bermejo-Fenoll A. Effects of scalpel (with and without tissue adhesive) and cryosurgery on wound healing in rat tongues. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100(3):e58-63.
  • Camacho-Alonso F, López-Jornet P. Clinical-pathological study of the healing of wounds provoked on the dorso-lingual mucosa in 186 albino rats. Otolaryngol – Head Neck Surg 2007;136(1):119-124.
  • Barbosa FI, Corrêa DS, Zenóbio EG.Dimensional changes between free gingival grafts fixed with ethyl cyanoacrylate and silk sutures. J Int Acad Periodontol 2009;11(2):170-176.
  • Silva CO, Ribeiro ÉDP, Sallum AW.Free gingival grafts: Graft shrinkage and donor-site healing in smokers and non-smokers. J Periodontol 2010;81(5):692-701.
  • Burkhardt R, Hämmerle CHF, Lang NP. Self-reported pain perception of patients after mucosal graft harvesting in the palatal area. J Clin Periodontol 2015;42(3):281-287.
  • Lee JS, Jeon YS, Strauss FJ, Jung HI, Gruber R. Digital scanning is more accurate than using a periodontal probe to measure the keratinized tissue width. Sci Rep 2020;Feb 28;10(1):3665.
  • Aslroosta H, Morshedzadeh G, Moslemi N.Clinical outcomes of free gingival graft following recipient bed preparation with Er,Cr:YSGG laser versus scalpel: A split-mouth randomized clinical trial. Photobiomodul Photomed Laser Surg 2021;39(6):425-433.
  • Khalil S, Habashneh R, Alomari S. Local application of hyaluronic acid in conjunction with free gingival graft: a randomized clinical trial. Clin Oral Invest 2022;26(2):2165–2174.
Year 2022, Volume: 12 Issue: 3, 691 - 696, 28.09.2022
https://doi.org/10.33808/clinexphealthsci.1012775

Abstract

References

  • Zucchelli G, Mounssif I. Periodontal plastic surgery. Periodontol 2015;68(1):333-368.
  • Miller PD. Root coverage using a free soft tissue autograft following citric acid application. Part 1: Technique. Int J Periodontics Restorative Dent 1982;2(1):65-70.
  • Sullivan HC, Atkins JH. Free autogenous gingival grafts. I. Principles of successful grafting. Periodontics 1968;6(3):121-129.
  • Zucchelli G, Mounssif I, Mazzotti C, et al. Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial. J Clin Periodontol 2014;41(7):708-716.
  • Stavropoulou C, Atout RN, Brownlee M. A randomized clinical trial of cyanoacrylate tissue adhesives in donor site of connective tissue grafts. J Periodontol 2019;90(6):608-615.
  • Eaglstein WH, Sullivan T. Cyanoacrylates for skin closure. Dermatol Clin 2005;23(2):193 198.
  • Montanaro L, Arciola CR, Cenni E. Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use. Biomaterials 2000;22(1):59-66.
  • Miller GM, Dannenbaum R, Cohen DW. A Preliminary Histologic Study of the Wound Healing of Mucogingival Flaps When Secured With the Cyanoacrylate Tissue Adhesives. J Periodontol 1974;45(8.2):608-618.
  • Ghoreishian M, Gheisari R, Fayazi M. Tissue adhesive and suturing for closure of the surgical wound after removal of impacted mandibular third molars: A comparative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108(1):e14-16.
  • Petersen PE. The World Oral Health Report 2003: Continuous improvement of oral health in the 21st century – The approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol 2003;31Suppl 1:3-23.
  • Ng SKS, Leung WK. A community study on the relationship of dental anxiety with oral health status and oral health related quality of life. Community Dent Oral Epidemiol 2008;36(4):347-356.
  • Ozcelik O, Haytac MC, Seydaoglu G. Immediate post-operative effects of different periodontal treatment modalities on oral health-related quality of life: A randomized clinical trial. J Clin Periodontol 2007;34(9):788-796.
  • Holbrook T, Ochsenbein C. Complete coverage of the denuded root surface with a one-stage gingival graft. Int J Periodontics Restorative Dent 1983;3(3):8-27.
  • Gümüş P, Buduneli E. Graft stabilization with cyanoacrylate decreases shrinkage of free gingival grafts. Aust Dent J 2014;59(1):57-64.
  • Borie E, Rosas E, Kuramochi G. Oral Applications of cyanoacrylate adhesives: A literature review. BioMed Res Int 2019; Mar 17:8217602.
  • Toriumi DM, Raslan WF, Friedman M. Histotoxicity of Cyanoacrylate Tissue Adhesives: A Comparative Study. Arch Otolaryngol Neck Surg 1990;116(5):546-550.
  • Inal S, Yilmaz N, Nisbet C. Biochemical and histopathological findings of N-Butyl-2-Cyanoacrylate in oral surgery: an experimental study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Dec;102(6):e14-17.
  • Åslund M, Suvan J, Moles DR. Effects of Two different methods of non-surgical periodontal therapy on patient perception of pain and quality of life: A randomized controlled clinical trial. J Periodontol 2008;79(6):1031-1040.
  • Tavelli L, Asa’ad F, Acunzo R. Minimizing patient morbidity following palatal gingival harvesting: A randomized controlled clinical study. Int J Periodontics Restorative Dent 2018;38(6):e127-134.
  • Ozcan M, Ucak O, Alkaya B.Effects of platelet-rich fibrin on palatal wound healing after free gingival graft harvesting: A comparative randomized controlled clinical trial. Int J Periodontics Restorative Dent 2017;37(5):e270-278.
  • Parirokh M, Asgary S, Eghbal MJ.A scanning electron microscope study of plaque accumulation on silk and PVDF suture materials in oral mucosa. Int Endod J 2004;37(11):776-781.
  • Kakoei S, Baghaei F, Dabiri S.A comparative in vivo study of tissue reactions to four suturing materials. Iran Endod J 2010;5(2):69-73.
  • Tabanella G. Oral tissue reactions to suture materials: A review. J West Soc Periodontol Periodontal Abstr 2004;52(2):37-44.
  • Muglali M, Ylmaz N, Inal S. Immunohistochemical comparison of indermil with traditional suture materials in dental surgery. J Craniofac Surg 2011;22(5):1875-1879.
  • Kumar MS, Natta S, Shankar G.Comparison between silk sutures and cyanoacrylate adhesive in human mucosa: A clinical and histological study. J Int Oral Health 2013 Oct;5(5):95-100.
  • Camacho-Alonso F, López-Jornet P, Bermejo-Fenoll A. Effects of scalpel (with and without tissue adhesive) and cryosurgery on wound healing in rat tongues. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100(3):e58-63.
  • Camacho-Alonso F, López-Jornet P. Clinical-pathological study of the healing of wounds provoked on the dorso-lingual mucosa in 186 albino rats. Otolaryngol – Head Neck Surg 2007;136(1):119-124.
  • Barbosa FI, Corrêa DS, Zenóbio EG.Dimensional changes between free gingival grafts fixed with ethyl cyanoacrylate and silk sutures. J Int Acad Periodontol 2009;11(2):170-176.
  • Silva CO, Ribeiro ÉDP, Sallum AW.Free gingival grafts: Graft shrinkage and donor-site healing in smokers and non-smokers. J Periodontol 2010;81(5):692-701.
  • Burkhardt R, Hämmerle CHF, Lang NP. Self-reported pain perception of patients after mucosal graft harvesting in the palatal area. J Clin Periodontol 2015;42(3):281-287.
  • Lee JS, Jeon YS, Strauss FJ, Jung HI, Gruber R. Digital scanning is more accurate than using a periodontal probe to measure the keratinized tissue width. Sci Rep 2020;Feb 28;10(1):3665.
  • Aslroosta H, Morshedzadeh G, Moslemi N.Clinical outcomes of free gingival graft following recipient bed preparation with Er,Cr:YSGG laser versus scalpel: A split-mouth randomized clinical trial. Photobiomodul Photomed Laser Surg 2021;39(6):425-433.
  • Khalil S, Habashneh R, Alomari S. Local application of hyaluronic acid in conjunction with free gingival graft: a randomized clinical trial. Clin Oral Invest 2022;26(2):2165–2174.
There are 33 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Mustafa Yılmaz 0000-0002-2005-1417

Sibel Kayaaltı-yüksek 0000-0001-5817-540X

Burcu Karaduman 0000-0002-8162-3896

Publication Date September 28, 2022
Submission Date October 20, 2021
Published in Issue Year 2022 Volume: 12 Issue: 3

Cite

APA Yılmaz, M., Kayaaltı-yüksek, S., & Karaduman, B. (2022). The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study. Clinical and Experimental Health Sciences, 12(3), 691-696. https://doi.org/10.33808/clinexphealthsci.1012775
AMA Yılmaz M, Kayaaltı-yüksek S, Karaduman B. The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study. Clinical and Experimental Health Sciences. September 2022;12(3):691-696. doi:10.33808/clinexphealthsci.1012775
Chicago Yılmaz, Mustafa, Sibel Kayaaltı-yüksek, and Burcu Karaduman. “The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study”. Clinical and Experimental Health Sciences 12, no. 3 (September 2022): 691-96. https://doi.org/10.33808/clinexphealthsci.1012775.
EndNote Yılmaz M, Kayaaltı-yüksek S, Karaduman B (September 1, 2022) The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study. Clinical and Experimental Health Sciences 12 3 691–696.
IEEE M. Yılmaz, S. Kayaaltı-yüksek, and B. Karaduman, “The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study”, Clinical and Experimental Health Sciences, vol. 12, no. 3, pp. 691–696, 2022, doi: 10.33808/clinexphealthsci.1012775.
ISNAD Yılmaz, Mustafa et al. “The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study”. Clinical and Experimental Health Sciences 12/3 (September 2022), 691-696. https://doi.org/10.33808/clinexphealthsci.1012775.
JAMA Yılmaz M, Kayaaltı-yüksek S, Karaduman B. The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study. Clinical and Experimental Health Sciences. 2022;12:691–696.
MLA Yılmaz, Mustafa et al. “The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study”. Clinical and Experimental Health Sciences, vol. 12, no. 3, 2022, pp. 691-6, doi:10.33808/clinexphealthsci.1012775.
Vancouver Yılmaz M, Kayaaltı-yüksek S, Karaduman B. The Effects of Cyanoacrylate on Clinical Healing and Self-Reported Outcomes Following Free Gingival Graft Surgery: A Randomized Clinical Study. Clinical and Experimental Health Sciences. 2022;12(3):691-6.

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