Effect of Different Remineralization Agents on Artificial Caries Lesion: An in-vitro Study

Year 2023, Volume: 13 Issue: 2, 330 - 336, 15.06.2023

Ecem Akbeyaz Şivet , Ayşe Nur Parlakyıldız Gökçe , Betul Kargul

https://doi.org/10.33808/clinexphealthsci.1103037

Abstract

Objective: Remineralization technologies have been shown to arrest or reverse early carious lesions. This study aimed to evaluate and compare the effect of different agents on enamel remineralization in-vitro.
Methods: Thirty-five enamel blocks were prepared and divided into the following groups: Group 1; CaGp and Xylitol-containing gel (R.O.C.S Medical Mineral Gel), Group 2; 1100 ppm NaF and 10% CPP-ACP toothpaste (MI Paste One), Group 3; 0.45% SnF2-1150 ppm F toothpaste (Enamelon), Group 4; Positive Control-1450 ppm NaF toothpaste (Colgate Total) and Group 5; Negative Control (deionized water). Microhardness was measured at baseline, after demineralization, and after respective treatments for different treatment groups using a digital Micro Vickers Hardness Tester. For producing demineralized lesions, samples were stored in acidic hydroxyethylcellulose (HEC, pH=4.8) for three days. The Paired Sample t-test, one-way ANOVA, and Tukey were used to compare data and SMH recovery (%SMHR) calculated among treatments.
Results: The mean baseline surface microhardness value was statistically non-significant between the groups (p=.378). CaGP and Xylitolcontaining gel demonstrated having the most protective effect against demineralization. The surface remineralization potential of 1100 ppm NaF and 10% CPP-ACP containing novel toothpaste (MI Paste One) was almost similar to the positive control (1450 ppm Fluoride toothpaste)group (p>.05).
Conclusions: All treatment groups showed remineralization after respective treatments and these agents can be used as an effective preventive measure for pediatric patients.

Keywords

Remineralization, CaGP and Xylitol, Fluoride Toothpaste, Surface Microhardness, CPP-ACP

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