Research Article
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Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine

Year 2023, Volume: 13 Issue: 2, 426 - 433, 15.06.2023

Hilal Üstündağ , Esra Şentürk , Serkan Yıldırım , Fikret Çelebi , Mustafa Gül

https://doi.org/10.33808/clinexphealthsci.1148898

Abstract

Objective: The goal of this study was to examine the effect of in vivo melatonin (MEL) administration on isolated thoracic aorta in rats with thyroxine treatment and its duty in aortic response to contractile agents, such as potassium chloride (KCl) and phenylephrine (PE). In addition, immunohistological alterations were also examined.
Methods: Experimental groups were as follows: control group (n= 5), thyroxine group (n= 5), melatonin group (n= 6), and thyroxine + melatonin group (n= 6). L-thyroxine was given by intraperitoneal (i.p) administration at 0.3 mg/kg/day for 14 days. MEL was administered i.p., at 3 mg/kg/day for 14 days. The thoracic aorta was isolated from rats euthanized by cervical dislocation. Then, vascular rings were prepared.
Concentration-response curves for KCl and PE applications were recorded in an isolated organ bath. Tissue samples were fixed in 10% formalin for histopathological and immunohistological evaluation.
Results: KCl and PE-induced contractions were reduced significantly in the thoracic aortic rings of the thyroxine-treated rats. MEL administration partially attenuated the reduction in the contraction responses due to thyroxine treatment. Immunohistological findings showed that MEL inhibits the thickening of the vessel wall by probably suppressing collagen formation due to thyroxine treatment in the aortic tissue.
Conclusion: Our results suggest that MEL may attenuate the decrease in vascular resistance caused by thyroxine treatment.

Keywords

Aorta Histology Melatonin Thyroxine Phenylephrine potassium chloride

Supporting Institution

Ataturk University Research Fund

Project Number

TDK-2017-6152.

References

  • De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet 2016;388(10047):906-918. DOI: 10.1016/S0140-6736(16)00278-6.
  • Osuna PM, Udovcic M, Sharma MD. Hyperthyroidism and the Heart. Methodist Debakey Cardiovasc J. 2017;13(2):60-63. DOI: 10.14797/mdcj-13-2-60.
  • Kurcer Z, Sahna E, Olmez E. Vascular reactivity to various vasoconstrictor agents and endothelium-dependent relaxations of rat thoracic aorta in the long-term period of pinealectomy. J Pharmacol Sci. 2006;101(4):329-334. DOI: 10.1254/jphs.FP0060380.
  • Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT. Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol Cell Endocrinol. 2012;351(2):152-166. DOI: 10.1016/j.mce.2012.01.004.
  • Paulis L, Simko F, Laudon M. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs 2012;21(11):1661-1678. DOI: 10.1517/13543784.2012.714771.
  • Jin HF, Wang YY, Zhou L, Liu L, Zhang P, Deng WG, Yuan YH. Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells. J Pineal Res. 2014;57(4):442-450. DOI: 10.1111/jpi.12184.
  • Hung MW, Kravtsov GM, Lau CF, Poon AMS, Tipoe GL, Fung ML. Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia. J Pineal Res. 2013;55(3):247-256. DOI: 10.1111/jpi.12067.
  • Reiter RJ, Manchester LC, Fuentes-Broto L, Tan DX. Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin. J Hypertens. 2010;28:S7-S12. DOI: 10.1097/01.hjh.0000388488.51083.2b.
  • Sewerynek E. Melatonin and the cardiovascular system. Neuroendocrinol Lett. 2002;23:79-83. PMID: 12019357.
  • Özsoy M, Gönül Y, Özkeçeci ZT, Bal A, Celep RB, Koçak A, Adalı F, Tosun M, Çelik S. The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping. Ann Ital Chir. 2016;87(3):271-279. PMID: 27346180.
  • Yang Y, Sun Y, Yi W, Li Y, Fan CX, Xin ZL, Jiang S, Di SY, Qu Y, Reiter RJ, Yi DH. A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases. J Pineal Res. 2014;57(4):357-366. DOI: 10.1111/jpi.12175.
  • Kalkan E, Çiçek O, Ünlü A, Abuşoğlu S, Kalkan SS, Avunduk MC, Baysefer A. The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study. Spinal Cord 2007;45(11):722-730. DOI: 10.1038/sj.sc.3102035.
  • Wright ML, Cuthbert KL, Donohue MJ, Solano SD, Proctor KL. Direct influence of melatonin on the thyroid and comparison with prolactin. J Exp Zool. 2000;286(6):625-631. DOI: 10.1002/(Sici)1097-010x(20000501)286:6<625::Aid-Jez9>3.0.Co;2-Q.
  • Üstündağ H, Şentürk E, Gül M. Melatonin and Hyperthyroidism. Arch Basic Clin Res. 2020;2:59-64. DOI: 10.5152/ABCR.2020.03.
  • Lewinski A, Karbownik M. Melatonin and the thyroid gland. Neuroendocrinol Lett. 2002;23:73-78. ISSN 0172–780X.
  • Moulakakis KG, Sokolis DP, Perrea DN, Dosios T, Dontas I, Poulakou MV, Dimitriou CA, Sandris G, Karayannacos PE. The mechanical performance and histomorphological structure of the descending aorta in hyperthyroldism. Angiology 2007;58(3):343-352. DOI: 10.1177/0003319707301759.
  • Shinohara R, Mano T, Nagasaka A, Hayashi R, Uchimura K, Nakano I, Watanabe F, Tsugawa T, Makino M, Kakizawa H, Nagata M, Iwase K, Ishizuki Y, Itoh M. Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status. J Endocrinol. 2000;164(1):97-102. DOI: 10.1677/joe.0.1640097.
  • Yıldırı S, Ekin S, Huyut Z, Oto G, Comba A, Uyar H, Şengül E, Çınar DA. Effect of Chronic Exposure to Sodium Fluoride and 7,12-Dimethylbenz[a]Anthracene on Some Blood Parameters and Hepatic, Renal, and Cardiac Histopathology in Rats. Fluoride 2018;51(3):278-290.
  • Kılıç K, Sakat MS, Akdemir FNE, Yıldırım S, Sağlam YS, Aşkın S. Protective effect of gallic acid against cisplatin-induced ototoxicity in rats. Braz J Otorhinolaryngol. 2019;85(3):267-274. DOI: 10.1016/j.bjorl.2018.03.001.
  • Esfandiari NH, McPhee SJ. Thyroid disease. Hammer GD, McPhee SJ, editors. Pathophysiology of disease: an introduction to clinical medicine. New York: McGraw-Hill Education; 2017.p. 571-591.
  • Rodriguez-Gomez I, Moliz JN, Quesada A, Montoro-Molina S, Vargas-Tendero P, Osuna A, Wangensteen R, Vargas F. L-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats. Exp Biol Med. 2016;241(5):550-556. DOI: 10.1177/1535370215619042.
  • Makino A, Wang H, Scott BT, Yuan JXJ, Dillmann WH. Thyroid hormone receptor-alpha and vascular function. Am J Physiol Cell Physiol. 2012;302(9):C1346-C1352. DOI: 10.1152/ajpcell.00292.2011.
  • Savinova OV, Liu YH, Aasen GA, Mao K, Weltman NY, Nedich BL, Liang QR, Gerdes AM. Thyroid Hormone Promotes Remodeling of Coronary Resistance Vessels. PloS One. 2011;6(9). DOI: 10.1371/journal.pone.0025054.
  • Davis PJ. Integrated nongenomic and genomic actions of thyroid hormone on blood vessels. Curr Opin Endocrinol Diabetes Obes. 2011;18(5):293-294. DOI: 10.1097/MED.0b013e32834abeb2.
  • Barreto-Chaves ML, Monteiro PD, Furstenau CR. Acute actions of thyroid hormone on blood vessel biochemistry and physiology. Curr Opin Endocrinol Diabetes Obes. 2011;18(5):300-303. DOI: 10.1097/MED.0b013e32834a785c.
  • Bussemaker E, Popp R, Fisslthaler B, Larson CM, Fleming I, Busse R, Brandes RP. Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery. Cardiovasc Res. 2003;59(1):181-188. DOI: 10.1016/S0008-6363(03)00326-2.
  • Honda H, Iwata T, Mochizuki T, Kogo H. Changes in vascular reactivity induced by acute hyperthyroidism in isolated rat aortae. Gen Pharmacol-Vasc S. 2000;34(6):429-434. DOI: 10.1016/S0306-3623(01)00080-5.
  • McAllister RM, Grossenburg VD, Delp MD, Laughlin H. Effects of hyperthyroidism on vascular contractile and relaxation responses. Am J Physiol Endocrinol Metab. 1998;274(5):E946-E953. DOI: 10.1152/ajpendo.1998.274.5.E946.
  • Carrillo-Sepulveda MA, Ceravolo GS, Fortes ZB, Carvalho MH, Tostes RC, Laurindo FR, Webb RC, Barreto-Chaves MLM. Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes. Cardiovasc Res. 2010;85(3):560-570. DOI: 10.1093/cvr/cvp304.
  • Lopez RM, Lopez JS, Lozano J, Flores H, Carranza RA, Franco A, Castillo EF. Comparative study of acute in vitro and short-term in vivo triiodothyronine treatments on the contractile activity of isolated rat thoracic aortas. Korean J Physiol Pharmacol. 2020;24(4):339-348. DOI: 10.4196/kjpp.2020.24.4.339.
  • Pantos CI, Tzilalis V, Giannakakis S, Cokkinos DD, Tzeis SM, Malliopoulou V, Mourouzis I, Asimakopoulos P, Carageorgiou H, Varonos DD, Cokkinos DV. Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. Int Angiol. 2001;20(2):181-186. PMID: 11533527.
  • Gachkar S, Nock S, Geissler C, Oelkrug R, Johann K, Resch J, Rahman A, Arner A, Kirchner H, Mittag J. Aortic effects of thyroid hormone in male mice. J Mol Endocrinol. 2019;62(3):91-99. DOI: 10.1530/Jme-18-0217.
  • Monroe KK, Watts SW. The vascular reactivity of melatonin. Gen Pharmacol. 1998;30(1):31-35. DOI: 10.1016/S0306-3623(97)00090-6.
  • Evans BK, Mason R, Wilson VG. Evidence for Direct Vasoconstrictor Activity of Melatonin in Pressurized Segments of Isolated Caudal Artery from Juvenile Rats. N-S Arch Pharmacol. 1992;346(3):362-365.
  • Krause DN, Barrios VE, Duckles SP. Melatonin Receptors Mediate Potentiation of Contractile Responses to Adrenergic-Nerve Stimulation in Rat Caudal Artery. Eur J Pharmacol. 1995;276(3):207-213. DOI: 10.1016/0014-2999(95)00028-J.
  • Mahle CD, Goggins GD, Agarwal P, Ryan E, Watson AJ. Melatonin modulates vascular smooth muscle tone. J Biol Rhythms 1997;12(6):690-696. DOI: 10.1177/074873049701200626.
  • Klemm P, Hecker M, Stockhausen H, Wu CC, Thiemermann C. Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat. Br J Pharmacol. 1995;115(7):1175-1181. DOI: 10.1111/j.1476-5381.1995.tb15021.x.
  • Weekley LB. Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J Pineal Res. 1991;11(1):28-34. DOI: 10.1111/j.1600-079x.1991.tb00823.x.
  • Benitez-King G, Anton-Tay F. Calmodulin mediates melatonin cytoskeletal effects. Experientia 1993;49(8):635-641. DOI: 10.1007/BF01923944.
  • Miles A, Philbrick DR. Melatonin and psychiatry. Biol Psychiatry 1988;23(4):405-425. DOI: 10.1016/0006-3223(88)90291-0.
  • Petterborg LJ, Rudeen PK. Effects of daily afternoon melatonin administration on body weight and thyroid hormones in female hamsters. J Pineal Res. 1989;6(4):367-373. DOI: 10.1111/j.1600-079x.1989.tb00433.x.
  • Ramadan HM, Taha NA, Ahmed HH. Correction to: melatonin enhances antioxidant defenses but could not ameliorate the reproductive disorders in induced hyperthyroidism model in male rats. Environ Sci Pollut Res Int. 2021;28(4):4805-4806. DOI: 10.1007/s11356-020-11784-y.
  • Vriend J, Wasserman RA. Effects of afternoon injections of melatonin in hypothyroid male Syrian hamsters. Neuroendocrinology 1986;42(6):498-503. DOI: 10.1159/000124494.
  • Vaughan MK, Powanda MC, Brainard GC, Johnson LY, Reiter RJ. Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters. Prog Clin Biol Res. 1982;92:177-186. PMID: 7111335.
  • Baltacı AK, Moğulkoç R. Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc. Biochem Genet. 2017;55(3):223-233. DOI: 10.1007/s10528-017-9791-z.
  • Xu F, Zhong JY, Lin X, Shan SK, Guo B, Zheng MH, Wang Y, Li F, Cui RR, Wu F, Zhou E, Liao XB, Liu YS, Yuan LQ. Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner. J Pineal Res. 2020;68(3):e12631. DOI: 10.1111/jpi.12631.
  • Ittermann T, Lorbeer R, Dorr M, Schneider T, Quadrat A, Hesselbarth L, Wenzel M, Lehmphul I, Kohrle J, Mensel B, Volzke H. High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population. Eur Radiol. 2016;26(12):4490-4496. DOI: 10.1007/s00330-016-4316-4.
  • Rosei CA, Favero G, Rezzani R, De Ciuceis C, Rodella LF, Porteri E, Rosei EA, Rizzoni D. Effects of Melatonin on the Production of Adiponectin and the Expression of Adiponectin Receptor in the Visceral Adipose Tissue of Aging Mice. J Hypertens. 2016;34:E186-E186. DOI: 10.1097/01.hjh.0000491859.13213.41.
  • Moncada S, Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol. 2006;147:S193-S201. DOI: 10.1038/sj.bjp.0706458.

Year 2023, Volume: 13 Issue: 2, 426 - 433, 15.06.2023

Hilal Üstündağ , Esra Şentürk , Serkan Yıldırım , Fikret Çelebi , Mustafa Gül

https://doi.org/10.33808/clinexphealthsci.1148898

Abstract

Project Number

TDK-2017-6152.

References

  • De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet 2016;388(10047):906-918. DOI: 10.1016/S0140-6736(16)00278-6.
  • Osuna PM, Udovcic M, Sharma MD. Hyperthyroidism and the Heart. Methodist Debakey Cardiovasc J. 2017;13(2):60-63. DOI: 10.14797/mdcj-13-2-60.
  • Kurcer Z, Sahna E, Olmez E. Vascular reactivity to various vasoconstrictor agents and endothelium-dependent relaxations of rat thoracic aorta in the long-term period of pinealectomy. J Pharmacol Sci. 2006;101(4):329-334. DOI: 10.1254/jphs.FP0060380.
  • Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT. Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol Cell Endocrinol. 2012;351(2):152-166. DOI: 10.1016/j.mce.2012.01.004.
  • Paulis L, Simko F, Laudon M. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs 2012;21(11):1661-1678. DOI: 10.1517/13543784.2012.714771.
  • Jin HF, Wang YY, Zhou L, Liu L, Zhang P, Deng WG, Yuan YH. Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells. J Pineal Res. 2014;57(4):442-450. DOI: 10.1111/jpi.12184.
  • Hung MW, Kravtsov GM, Lau CF, Poon AMS, Tipoe GL, Fung ML. Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia. J Pineal Res. 2013;55(3):247-256. DOI: 10.1111/jpi.12067.
  • Reiter RJ, Manchester LC, Fuentes-Broto L, Tan DX. Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin. J Hypertens. 2010;28:S7-S12. DOI: 10.1097/01.hjh.0000388488.51083.2b.
  • Sewerynek E. Melatonin and the cardiovascular system. Neuroendocrinol Lett. 2002;23:79-83. PMID: 12019357.
  • Özsoy M, Gönül Y, Özkeçeci ZT, Bal A, Celep RB, Koçak A, Adalı F, Tosun M, Çelik S. The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping. Ann Ital Chir. 2016;87(3):271-279. PMID: 27346180.
  • Yang Y, Sun Y, Yi W, Li Y, Fan CX, Xin ZL, Jiang S, Di SY, Qu Y, Reiter RJ, Yi DH. A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases. J Pineal Res. 2014;57(4):357-366. DOI: 10.1111/jpi.12175.
  • Kalkan E, Çiçek O, Ünlü A, Abuşoğlu S, Kalkan SS, Avunduk MC, Baysefer A. The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study. Spinal Cord 2007;45(11):722-730. DOI: 10.1038/sj.sc.3102035.
  • Wright ML, Cuthbert KL, Donohue MJ, Solano SD, Proctor KL. Direct influence of melatonin on the thyroid and comparison with prolactin. J Exp Zool. 2000;286(6):625-631. DOI: 10.1002/(Sici)1097-010x(20000501)286:6<625::Aid-Jez9>3.0.Co;2-Q.
  • Üstündağ H, Şentürk E, Gül M. Melatonin and Hyperthyroidism. Arch Basic Clin Res. 2020;2:59-64. DOI: 10.5152/ABCR.2020.03.
  • Lewinski A, Karbownik M. Melatonin and the thyroid gland. Neuroendocrinol Lett. 2002;23:73-78. ISSN 0172–780X.
  • Moulakakis KG, Sokolis DP, Perrea DN, Dosios T, Dontas I, Poulakou MV, Dimitriou CA, Sandris G, Karayannacos PE. The mechanical performance and histomorphological structure of the descending aorta in hyperthyroldism. Angiology 2007;58(3):343-352. DOI: 10.1177/0003319707301759.
  • Shinohara R, Mano T, Nagasaka A, Hayashi R, Uchimura K, Nakano I, Watanabe F, Tsugawa T, Makino M, Kakizawa H, Nagata M, Iwase K, Ishizuki Y, Itoh M. Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status. J Endocrinol. 2000;164(1):97-102. DOI: 10.1677/joe.0.1640097.
  • Yıldırı S, Ekin S, Huyut Z, Oto G, Comba A, Uyar H, Şengül E, Çınar DA. Effect of Chronic Exposure to Sodium Fluoride and 7,12-Dimethylbenz[a]Anthracene on Some Blood Parameters and Hepatic, Renal, and Cardiac Histopathology in Rats. Fluoride 2018;51(3):278-290.
  • Kılıç K, Sakat MS, Akdemir FNE, Yıldırım S, Sağlam YS, Aşkın S. Protective effect of gallic acid against cisplatin-induced ototoxicity in rats. Braz J Otorhinolaryngol. 2019;85(3):267-274. DOI: 10.1016/j.bjorl.2018.03.001.
  • Esfandiari NH, McPhee SJ. Thyroid disease. Hammer GD, McPhee SJ, editors. Pathophysiology of disease: an introduction to clinical medicine. New York: McGraw-Hill Education; 2017.p. 571-591.
  • Rodriguez-Gomez I, Moliz JN, Quesada A, Montoro-Molina S, Vargas-Tendero P, Osuna A, Wangensteen R, Vargas F. L-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats. Exp Biol Med. 2016;241(5):550-556. DOI: 10.1177/1535370215619042.
  • Makino A, Wang H, Scott BT, Yuan JXJ, Dillmann WH. Thyroid hormone receptor-alpha and vascular function. Am J Physiol Cell Physiol. 2012;302(9):C1346-C1352. DOI: 10.1152/ajpcell.00292.2011.
  • Savinova OV, Liu YH, Aasen GA, Mao K, Weltman NY, Nedich BL, Liang QR, Gerdes AM. Thyroid Hormone Promotes Remodeling of Coronary Resistance Vessels. PloS One. 2011;6(9). DOI: 10.1371/journal.pone.0025054.
  • Davis PJ. Integrated nongenomic and genomic actions of thyroid hormone on blood vessels. Curr Opin Endocrinol Diabetes Obes. 2011;18(5):293-294. DOI: 10.1097/MED.0b013e32834abeb2.
  • Barreto-Chaves ML, Monteiro PD, Furstenau CR. Acute actions of thyroid hormone on blood vessel biochemistry and physiology. Curr Opin Endocrinol Diabetes Obes. 2011;18(5):300-303. DOI: 10.1097/MED.0b013e32834a785c.
  • Bussemaker E, Popp R, Fisslthaler B, Larson CM, Fleming I, Busse R, Brandes RP. Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery. Cardiovasc Res. 2003;59(1):181-188. DOI: 10.1016/S0008-6363(03)00326-2.
  • Honda H, Iwata T, Mochizuki T, Kogo H. Changes in vascular reactivity induced by acute hyperthyroidism in isolated rat aortae. Gen Pharmacol-Vasc S. 2000;34(6):429-434. DOI: 10.1016/S0306-3623(01)00080-5.
  • McAllister RM, Grossenburg VD, Delp MD, Laughlin H. Effects of hyperthyroidism on vascular contractile and relaxation responses. Am J Physiol Endocrinol Metab. 1998;274(5):E946-E953. DOI: 10.1152/ajpendo.1998.274.5.E946.
  • Carrillo-Sepulveda MA, Ceravolo GS, Fortes ZB, Carvalho MH, Tostes RC, Laurindo FR, Webb RC, Barreto-Chaves MLM. Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes. Cardiovasc Res. 2010;85(3):560-570. DOI: 10.1093/cvr/cvp304.
  • Lopez RM, Lopez JS, Lozano J, Flores H, Carranza RA, Franco A, Castillo EF. Comparative study of acute in vitro and short-term in vivo triiodothyronine treatments on the contractile activity of isolated rat thoracic aortas. Korean J Physiol Pharmacol. 2020;24(4):339-348. DOI: 10.4196/kjpp.2020.24.4.339.
  • Pantos CI, Tzilalis V, Giannakakis S, Cokkinos DD, Tzeis SM, Malliopoulou V, Mourouzis I, Asimakopoulos P, Carageorgiou H, Varonos DD, Cokkinos DV. Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. Int Angiol. 2001;20(2):181-186. PMID: 11533527.
  • Gachkar S, Nock S, Geissler C, Oelkrug R, Johann K, Resch J, Rahman A, Arner A, Kirchner H, Mittag J. Aortic effects of thyroid hormone in male mice. J Mol Endocrinol. 2019;62(3):91-99. DOI: 10.1530/Jme-18-0217.
  • Monroe KK, Watts SW. The vascular reactivity of melatonin. Gen Pharmacol. 1998;30(1):31-35. DOI: 10.1016/S0306-3623(97)00090-6.
  • Evans BK, Mason R, Wilson VG. Evidence for Direct Vasoconstrictor Activity of Melatonin in Pressurized Segments of Isolated Caudal Artery from Juvenile Rats. N-S Arch Pharmacol. 1992;346(3):362-365.
  • Krause DN, Barrios VE, Duckles SP. Melatonin Receptors Mediate Potentiation of Contractile Responses to Adrenergic-Nerve Stimulation in Rat Caudal Artery. Eur J Pharmacol. 1995;276(3):207-213. DOI: 10.1016/0014-2999(95)00028-J.
  • Mahle CD, Goggins GD, Agarwal P, Ryan E, Watson AJ. Melatonin modulates vascular smooth muscle tone. J Biol Rhythms 1997;12(6):690-696. DOI: 10.1177/074873049701200626.
  • Klemm P, Hecker M, Stockhausen H, Wu CC, Thiemermann C. Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat. Br J Pharmacol. 1995;115(7):1175-1181. DOI: 10.1111/j.1476-5381.1995.tb15021.x.
  • Weekley LB. Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J Pineal Res. 1991;11(1):28-34. DOI: 10.1111/j.1600-079x.1991.tb00823.x.
  • Benitez-King G, Anton-Tay F. Calmodulin mediates melatonin cytoskeletal effects. Experientia 1993;49(8):635-641. DOI: 10.1007/BF01923944.
  • Miles A, Philbrick DR. Melatonin and psychiatry. Biol Psychiatry 1988;23(4):405-425. DOI: 10.1016/0006-3223(88)90291-0.
  • Petterborg LJ, Rudeen PK. Effects of daily afternoon melatonin administration on body weight and thyroid hormones in female hamsters. J Pineal Res. 1989;6(4):367-373. DOI: 10.1111/j.1600-079x.1989.tb00433.x.
  • Ramadan HM, Taha NA, Ahmed HH. Correction to: melatonin enhances antioxidant defenses but could not ameliorate the reproductive disorders in induced hyperthyroidism model in male rats. Environ Sci Pollut Res Int. 2021;28(4):4805-4806. DOI: 10.1007/s11356-020-11784-y.
  • Vriend J, Wasserman RA. Effects of afternoon injections of melatonin in hypothyroid male Syrian hamsters. Neuroendocrinology 1986;42(6):498-503. DOI: 10.1159/000124494.
  • Vaughan MK, Powanda MC, Brainard GC, Johnson LY, Reiter RJ. Effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, TSH and thyroid hormone levels in male and female Syrian hamsters. Prog Clin Biol Res. 1982;92:177-186. PMID: 7111335.
  • Baltacı AK, Moğulkoç R. Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc. Biochem Genet. 2017;55(3):223-233. DOI: 10.1007/s10528-017-9791-z.
  • Xu F, Zhong JY, Lin X, Shan SK, Guo B, Zheng MH, Wang Y, Li F, Cui RR, Wu F, Zhou E, Liao XB, Liu YS, Yuan LQ. Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner. J Pineal Res. 2020;68(3):e12631. DOI: 10.1111/jpi.12631.
  • Ittermann T, Lorbeer R, Dorr M, Schneider T, Quadrat A, Hesselbarth L, Wenzel M, Lehmphul I, Kohrle J, Mensel B, Volzke H. High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population. Eur Radiol. 2016;26(12):4490-4496. DOI: 10.1007/s00330-016-4316-4.
  • Rosei CA, Favero G, Rezzani R, De Ciuceis C, Rodella LF, Porteri E, Rosei EA, Rizzoni D. Effects of Melatonin on the Production of Adiponectin and the Expression of Adiponectin Receptor in the Visceral Adipose Tissue of Aging Mice. J Hypertens. 2016;34:E186-E186. DOI: 10.1097/01.hjh.0000491859.13213.41.
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There are 49 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Hilal Üstündağ 0000-0003-3140-0755

Esra Şentürk 0000-0003-4378-7678

Serkan Yıldırım 0000-0003-2457-3367

Fikret Çelebi 0000-0002-6196-2196

Mustafa Gül 0000-0002-0042-890X

Project Number TDK-2017-6152.
Publication Date June 15, 2023
Submission Date July 26, 2022
Published in Issue Year 2023 Volume: 13 Issue: 2

Cite

APA Üstündağ, H., Şentürk, E., Yıldırım, S., Çelebi, F., et al. (2023). Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine. Clinical and Experimental Health Sciences, 13(2), 426-433. https://doi.org/10.33808/clinexphealthsci.1148898
AMA Üstündağ H, Şentürk E, Yıldırım S, Çelebi F, Gül M. Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine. Clinical and Experimental Health Sciences. June 2023;13(2):426-433. doi:10.33808/clinexphealthsci.1148898
Chicago Üstündağ, Hilal, Esra Şentürk, Serkan Yıldırım, Fikret Çelebi, and Mustafa Gül. “Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated With Thyroxine”. Clinical and Experimental Health Sciences 13, no. 2 (June 2023): 426-33. https://doi.org/10.33808/clinexphealthsci.1148898.
EndNote Üstündağ H, Şentürk E, Yıldırım S, Çelebi F, Gül M (June 1, 2023) Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine. Clinical and Experimental Health Sciences 13 2 426–433.
IEEE H. Üstündağ, E. Şentürk, S. Yıldırım, F. Çelebi, and M. Gül, “Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine”, Clinical and Experimental Health Sciences, vol. 13, no. 2, pp. 426–433, 2023, doi: 10.33808/clinexphealthsci.1148898.
ISNAD Üstündağ, Hilal et al. “Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated With Thyroxine”. Clinical and Experimental Health Sciences 13/2 (June 2023), 426-433. https://doi.org/10.33808/clinexphealthsci.1148898.
JAMA Üstündağ H, Şentürk E, Yıldırım S, Çelebi F, Gül M. Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine. Clinical and Experimental Health Sciences. 2023;13:426–433.
MLA Üstündağ, Hilal et al. “Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated With Thyroxine”. Clinical and Experimental Health Sciences, vol. 13, no. 2, 2023, pp. 426-33, doi:10.33808/clinexphealthsci.1148898.
Vancouver Üstündağ H, Şentürk E, Yıldırım S, Çelebi F, Gül M. Effects of Melatonin Administration on Vasomotor Activity and Histological Structure of Isolated Thoracic Aorta in Rats Treated with Thyroxine. Clinical and Experimental Health Sciences. 2023;13(2):426-33.
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