Genotoxic and Mutagenic Effects of Mycotoxins: A Review

Year 2019, Volume: 3 Issue: 2, 132 - 161, 20.12.2019

Muhsin Aydın , Eyyüp Rencüzoğulları

https://doi.org/10.31594/commagene.633418

Cited By: 1

Abstract

In
this article, genotoxic and mutagenic effects of mycotoxins that are produced
by various fungus species have been reviewed. A total of 259 mycotoxins were
found in the literature. Genotoxic effects of 109 of these were investigated.
Among the studied mycotoxins, only actinomycin D, aflatoxin, alternariol,
chrysazin (dantron), citrinin, fumonisin, mytomycin C, nivalenol, ochratoxin A,
patulin, sterigmatocystin, versicolorin A and B, vomitoxin, and zearalenone
have sufficient number of studies that present or prove their genotoxic
effects. Additional studies are required in order to determine whether other
mycotoxins have any genotoxic effects. The current study provides valuable
information regarding studied mycotoxins. Therefore, it may lead researchers for
designing future mycotoxin-related studies that have never been studied.

Keywords

Genotoxicity, mutagenicity, secondary metabolites, toxic

Mikotoksinlerin Genotoksik ve Mutajenik Etkileri: Derleme

Abstract

Bu makalede, çeşitli mantar türleri tarafından
üretilen mikotoksinlerin genotoksik ve mutajenik etkileri derlenmiştir.
Literatürde toplam 259 mikotoksin bulundu. Bunların 109'unun genotoksik
etkileri daha önce araştırıldı. Bugüne kadar yapılmış olan çalışmalarda,
çalışılan mikotoksinler arasında sadece aktinomisin D, aflatoksin, alternaril,
chrysazin (dantron), sitrinin, fumonisin, mitomisin C, nivalenol, okratoksin A,
patulin, sterigmatosistin, versicolorin A ve B, vomitoksin ve zearalenon
genotoksik etki göstermiş veya genotoksik etkileri kanıtlanmıştır. Diğer
mikotoksinlerin herhangi bir genotoksik etkisi olup olmadığını belirlemek için
ek çalışmalar gereklidir. Bu çalışma, daha önce çalışılan mikotoksinler
hakkında önemli bilgiler sunmaktadır. Dolayısıyla bu derleme, araştırmacılara,
daha önce hiç çalışılmamış olan mikotoksinlerle ilgili gelecekteki çalışmaları
tasarlama konusunda katkı sağlayabilir.

Keywords

Genotoksisite, mutajenisite, ikincil metabolitler, muhtemel ilaçlar

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