SYNTHESIS OF OPEN-CHAIN SUGAR DERIVATIVES AS ANTICANCER AND ANTIMICROBIAL AGENTS

Year 2019, Volume: 28 Issue: 2, 148 - 159, 15.12.2019

İdris Yazgan

Abstract

In the present study, three sugar residues
including mannose, galactose and lactose were modified with organic
substituents via reductive amination reaction in order to get strong anticancer
carbohydrate derivatives for A549 cell line and antibacterial agents targeting E.coli and S.epidermidis. The findings showed that carbohydrate residue along
with substituted group play the major role for the observed activity of the
carbohydrate ligands.

Keywords

Carbohydrate derivatives, lectins, Anticancer, Antibacteri

Project Number

KÜ-BAP01/2018-33

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