ANTIMUTAGENIC AND ANTIOXIDANT ACTIVITIES OF TEUCRIUM MULTICAULE AND ITS CYTOTOXIC EFFECT ON MURINE LR7 CELL

Year 2020, Volume: 29 Issue: 1, 95 - 104, 30.06.2020

Mustafa Pehlivan , Önder Yumrutaş İbrahim Bozgeyik

Abstract

In present study, DNA
protection, antioxidant and cytotoxic effects of Teucrium multicaule
Montbret Et Aucher Ex Bentham methanol extract (TME) was investigated.
Cytotoxic effects and antioxidant activities of TME was determined by MTT and
DPPH scavenging and DNA protection methods. As a result, high dose of TME
exhibited a cytotoxic effect on murine L cells. Although, TME also showed a
strong antimutagenic activity in DNA protection test system, it exhibited
modest activity in DPPH test system. Consequently, it may be used as natural
agent for antioxidant and antimutagenic properties.

Keywords

Cytotoxicity, DNA protection, Antioxidant, Antimutagenic, Teucrium multicaule

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