Preemptı̇f oral tramadol-pregabalı̇n ı̇le tramadol-parasetamol kombinasyonunun postoperatı̇f tramadol tüketı̇mı̇ üzerı̇ne etkı̇lerı̇nin karşılaştırılması

Year 2019, Volume: 44 Issue: Supplement 1, 181 - 189, 29.12.2019

Murat Türkeün Ilgınel , Demet Laflı Tunay , Yasemin Güneş , Feride Karacaer , Ebru Biricik , Özge Ilgınel

https://doi.org/10.17826/cumj.585656

Abstract

Amaç: Çalışmamızda preemptif oral tramadol-plasebo, tramadol-pregabalin ve tramadol–parasetamol kombinasyonlarının postoperatif tramadol tüketimi üzerine etkilerini karşılaştırmayı amaçladık. 

Gereç ve Yöntem: Çalışmaya meme küçültme ameliyatı yapılacak, 18-65 yaş aralığında, 60 hasta alındı. Hastalar rastgele üç gruba ayrıldı. Operasyondan bir saat önce her üç gruba tramadol 35 mg oral damla ile grup I’e (n=20) pregabalin 75 mg tablet, grup II’ye (n=20) parasetamol 500 mg tablet, grup III’e (n=20) ise plasebo tablet verildi.Grupların postoperatif 24 saatlik ağrı skorları, total tramadol tüketimleri, ek analjezi ihtiyaçları, ekstübasyon ve derlenme zamanları ve yan etkiler kaydedildi.  

Bulgular: Vizüel Analog Skala (VAS) 10. ve 60. dakika değerleri grup II’de diğer gruplardan daha düşük saptandı. Tramadol tüketiminde gruplar arasında istatiksel olarak anlamlı farklılık saptanmamış olmakla birlikte tüketilen toplam tramadol miktarı 120 mg  ve 120 mg  olarak gruplandırıldığında grup I’de tramadol tüketimi diğer iki gruptan daha düşük saptandı.

Sonuç: Meme küçültme cerrahisinde preoperatif oral yoldan uygulanan pregabalin ve tramadol kombinasyonu ile parasetamol ve tramadol kombinasyonu tek başına tramadole göre postoperatif ağrı skorları, 24 saatlik total tramadol tüketimi ve yan etkiler açısından farklılığa yol açmamıştır.

Keywords

Preemptif analjezi, pregabalin, tramadol damla, parasetamol

Supporting Institution

Çukurova Üniversitesi Tıp Fakültesi Bilimsel Araştırmalar Proje Daire Başkanlığı

Comparison of effects of preemptive oral pregabalin-tramadol combination and paracetamol-tramadol combination administration on postoperative tramadol consumption

Abstract

Purpose: We aimed to evaluate the efficacy of preemptive oral tramadol-placebo, tramadol-pregabalin and tramadol-paracetamol combination on postoperatif tramadol consumption in patients undergoing breast reduction operation. 

Materials and Methods: Sixty adult patients between 18-65 years of age, undergoing breast reduction surgery were included in this study, randomly divided into three groups. Each of groups were received 35 mg drop tramadol one hour before surgery. Additionally Group I (n=20) patients received 75 mg pregabalin tablet and Group II (n=20) patients received 500 mg paracetamol tablet preoperatively, and Group III (n=20) patients accepted as control group. 30 minutes before the end of operation Postoperative 24 hour pain scores, total tramadol consumption, supplement analgesic requirement, extubation, recovery time and side effects were recorded. 

Results: Postoperative 10th and 60th min Visual Analogue Scale scores were lower in group II compared to others. The consumption of tramadol in Group I was lower than the others when the total amount of tramadol consumtion was grouped as 120 mg≥ and 120mg <. 

Conclusion: The combinations of pregabalin and tramadol and paracetamol and tramadol did not cause any difference in terms of postoperative pain scores, 24-hour total tramadol consumption compared with tramadol alone.

Keywords

Patient controlled analgesia, paracetamol, preemptif analgesia

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