ACSL4 gen polimorfizminin (rs7886473) metabolik sendrom ve lipid düzeyleri üzerine etkisi

Year 2018, Volume: 43 Number: Supplement 1, 151 - 157, 29.12.2018

Eren Vurgun , İrem Yağmur Diker Neslihan Çoban , Filiz Geyik Gamze Güven Nihan Erginel Ünaltuna

https://doi.org/10.17826/cumj.407589

Abstract

Amaç: Lipid metabolizması üzerinden obezite ve metabolik sendromla ilişkisi olabileceğini düşündüğümüz ACSL4 geninin sık görülen rs7886473 A>G polimorfizminin Türk toplumunda metabolik sendrom ve lipid düzeyleri üzerindeki etkisini araştırmayı amaçladık.

Gereç ve Yöntem: Çalışmamıza, Türkiye genelinde takip edilen ve modifiye edilmiş NCEP ATPIII Metabolik Sendrom tanı kriterlerine göre 556 metabolik sendrom olan ve 520 metabolik sendrom olmayan erişkin birey dahil edildi. Metabolik sendrom olan ve olmayan bireylerin ACSL4 gen polimorfizmi Roche Light Cycler 480 Real-Time PCR ile genotiplendi ve karşılaştırıldı.

Bulgular: Metabolik sendrom olan ve metabolik sendrom olmayan bireyler arasında ACSL4 rs7886473 genotip dağılımları arasında anlamlı bir farklılık bulunmadı. Tüm erkeklerin ACSL4 rs7886473 polimorfizmine göre serum total kolesterol, HDL, LDL ve trigliserid düzeyleri karşılaştırıldığında; GG ve AA genotipleri arasında anlamlı bir farklılık bulunmadı. Benzer şekilde tüm kadınlarda da anlamlı farklılık bulunmadı.

Sonuç: Bu çalışma, ACSL4 geni açısından incelemiş olduğumuz rs7886473 gen polimorfizminin metabolik sendrom ve serum lipid düzeyleri üzerine etkisi olmadığını gösterdi. Ancak çalışmamızda incelenmiş olan ACSL4 geninde yaygın görülen yalnızca bir polimorfizmdir. Bu durum ACSL4 geninin lipid metabolizması ve/veya metabolik sendrom üzerine etkili olmadığını değerlendirmek için tek başına yeterli değildir.

Keywords

ACSL4, gen polimorfizmi, lipid, trigliserid, metabolik sendrom

Effect of ACSL4 gene polymorphism (rs7886473) on metabolic syndrome and lipid levels

Abstract

Purpose: Acyl-CoA synthetase long-chain family member 4 (ACSL4) is thought to be related with obesity and metabolic syndrome via lipid metabolism. We aimed to investigate the effect of the single nucleotide polymorphism (SNP) rs7886473, which is a common intron variant of ACSL4 gene on metabolic syndrome and lipids in Turkish society.

Materials and Methods: Metabolic syndrome (n=556) and non-metabolic syndrome (n=520) patients according to the modified NCEP ATPIII metabolic syndrome criterias were included in the study. SNPs were genotyped with Roche Light Cycler 480 Real-Time PCR and then compared between groups.

Results: There was no significant difference in the genotype frequencies of the ACSL4 gene polymorphism (rs7886473) between the metabolic syndrome and the non-metabolic syndrome patient groups. There were no significant differences in serum total cholesterol, HDL, LDL and triglyceride levels between GG and AA genotypes either in men or women.

Conclusion: This study showed that ACSL4 gene polymorphism (rs7886473) has no effect on metabolic syndrome and serum lipid levels. However, only one common SNP on the ACSL4 gene was examined in our study. In this instance, this study is not enough to determine whether ACSL4 gene is not effective on metabolic syndrome and/or lipid levels. 

Keywords

ACSL4, SNP, lipids, triglyceride, metabolic syndrome

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