Stereological measurement of liver volume in newborn cadavers

Year 2020, Volume: 45 Issue: 1, 223 - 231, 31.03.2020

Seda Avnioglu , Erdoğan Unur , Niyazi Acer , Tolga Ertekin , Adem Doğaner

https://doi.org/10.17826/cumj.645040

Abstract

Purpose: The aim of our study was to compare different techniques for the estimation of liver volume using cadaveric sample, magnetic resonance imaging (MRI) and ultrasonography (USG) images, and to measure errors associated with volume estimation techniques based on fluid displacement (the Archimedes' principle).
Materials and Methods: Our study was formed of five newborn cadavers aged 39.7±1.5 weeks and weighted 2.220±1.056 g. We used three different methods for calculate the liver volume.
Results: Liver volume (LV) measured by the Archimedes' principle was 70.00±49.96 cm3. There was no significant difference between the methods.
Conclusion: MR and USG images provide easy, applicable and reproducible estimates in calculating volume of normal and anomalous liver with the Cavalieri’s principle. We think that our study may be a reference for similar studies to be done in the upcoming years.

Keywords

Liver volume, stereology, Cavalieri’s principle, newborn, cadavers

Supporting Institution

The present study protocol was reviewed and approved by the Institutional Review Board Erciyes University Clinical Research Ethics Committee (No: 2011/79) Informed consent was submitted by all subjects when they were enrolled.

Yenidoğan kadavralarında karaciğer hacminin stereolojik olarak hesaplanması

Abstract

Amaç: Bu çalışmada yenidoğan kadavralarına ait karaciğerler üzerinde, Ultrasonografi (USG), Manyetik Rezonans Görüntüleme (MRG), Arşimet prensibi ve dilimleme yöntemleri kullanarak, bu yöntemler arasındaki farklılıkların ortaya çıkarılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmamız 39.7 ± 1.5 hafta yaşları ve 2.220 ± 1.056 g ağırlıklı beş yenidoğan kadavradan oluşmuştur. Karaciğer hacmini hesaplamak için üç farklı yöntem kullanılmıştır.
Bulgular: Arşimed prensibi ile ölçülen karaciğer hacmi (LV) 70.00 ± 49.96 cm3 idi. Metodlar arasında anlamlı fark bulunmadı.
Sonuç: MR ve USG görüntüleri, Cavalieri prensibi ile normal ve anormal karaciğer hacminin hesaplanmasında kolay, uygulanabilir ve tekrarlanabilir tahminler sağlar. Çalışmamızın önümüzdeki yıllarda yapılacak benzer çalışmalara referans olabileceğini düşünüyoruz.

Keywords

Karaciğer hacmi, stereoloji, yenidoğan kadavrası, cavalieri prensibi

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