Cognitive flexibility among female migraine patients: case–control study

Year 2020, Volume: 45 Issue: 1, 278 - 289, 31.03.2020

Ruhan Karahan Özcan Selen Özmen

https://doi.org/10.17826/cumj.654189

Abstract

Purpose: The aim of this study was to determine if cognition is affected in female migraine sufferers by comparing cognitive domains with a healthy control group.
Materials and Methods: Fifty patients with migraine and 50 healthy controls (all female) were enrolled in this cross-sectional case–control study. The Beck Depression test, Beck Anxiety test, California Verbal Learning Test, Montreal Cognitive Assessment Scale, and Wisconsin Card Sorting Test (WCST) were performed in both groups.
Results: Using a multivariate logistic regression model of migraine, WCST non-perseverative error (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.028–2.568; p = 0.03), WCST percent of perseverative error (OR, 0.23; 95%CI, 0.071–0.786; p = 0.01), WCST perseverative response (OR, 4.55; 95%CI, 1.272–16.298; p = 0.02), no alcohol consumption (OR, 0.006; 95%CI, 0.000–0.943; p = 0.04), family history of hypertension (OR, 4.46; 95%CI, 1.114–17.915; p = 0.03), family history of migraine (OR, 4.028; 95%CI, 1.027–15.799; p = 0.04), and no family history of stroke (OR, 0.034; 95%CI, 0.003–0.448; p = 0.01) were significant factors
Conclusion: Among WCST scores, non-perseverative error provides insight into the patient’s problem solving ability. Meanwhile, percent perseverative error and perseverative response scores provide insight into cognitive flexibility ability. Therefore, in our study group, patients with migraine show better problem solving and cognitive flexibility ability than the healthy control group. 

Keywords

Migraine, cognition, executive function

Kadın migren hastalarında bilişsel esneklik: vaka-kontrol çalışması

Abstract

Amaç: Bu çalışmadaki amacımız kadın migren hastalarıyla sağlıklı kontrol grubun farklı kognitif becerilerini uygun nöropsikolojik testlerle kıyaslamak ve kadın migren hastalarında kognitif etkilenmenin eğer var ise, ne yönde olduğunu göstermektir.
Gereç ve Yöntem: Bu kesitsel vaka-kontrol çalışmasına elli kadın migren hastası ve elli sağlıklı kontrol kadın katılımcı dahil edilmiştir. Beck Depresyon testi, Beck Anksiyete testi, California Sözel Öğrenme Testi, Montreal Kognitif Değerlendirme Ölçeği ve Wisconsin Kard Eşleme Testi (WKET) her iki gruba uygulanan testlerdi.
Bulgular: WKET perseverative olmayan hata (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.028–2.568; p = 0.03), WKET perseveratif hata yüzdesi (OR, 0.23; 95%CI, 0.071–0.786; p = 0.01), WKET perseveratif tepki (OR, 4.55; 95%CI, 1.272–16.298; p = 0.02), alkol kullanmama (OR, 0.006; 95%CI, 0.000–0.943; p = 0.04), ailede hipertansiyon hikayesi (OR, 4.46; 95%CI, 1.114–17.915; p = 0.03), ailede migren hikayesi (OR, 4.028; 95%CI, 1.027–15.799; p = 0.04), and ailede inme hikayesi olmaması (OR, 0.034; 95%CI, 0.003–0.448; p = 0.01) migreni oluşturan multivaryat lojistik regresyon modelinde yer aldı.
Sonuç: WKET skorlarından perseveratif olmayan hata kişinin problem çözme becerisini gösterir. Perseveratif hata yüzdesi ve perseveratif tepki ise kişinin bilişsel esnekliğini yani değişken görevler karşısında devam ettirdiği beceriyi gösterir. Dolayısıyla çalışma grubumuzda kadın migren hastalarında sağlıklı kontrol gruba göre problem çözme yeteneği ve bilişsel esneklik kabiliyetinin daha üstün olduğu gösterildi. 

Keywords

Migren, kognisyon, yürütücü işlevler

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