Karotis arter hasarını etkileyen kan basıncı sınırları: kesitsel bir çalışma

Year 2020, Volume: 45 Issue: 3, 971 - 976, 30.09.2020

Aylin Güneşli , Aynur Acıbuca , Cihan Altın , Esin Gezmiş Mustafa Agah Tekindal , Çiğdem Yalçın Ozlem Alkan

https://doi.org/10.17826/cumj.702344

Abstract

Amaç: Yüksek kan basıncının karotis arterler üzerinde istenmeyen etkilere yol açtığı iyi bilinmesine ragmen bu etkinin hangi değerden itibaren başladığı net değildir. Bu çalışmanın amacı bunu değerlendirmektir.
Yöntem: Çalışma kesitsel planlandı ve toplam 308 birey dahil edildi. Sistolik kan basıncı (SKB) <120 mmHg ve diyastolik kan basıncı (DKB) <90 mmHg olan (optimal) bireyler 1.Gruba, SKB 120-129 mmHg ve/veya DKB 80-84 mmHg olan (normal) bireyler 2.Gruba, SKB 130-139 mmHg ve/veya DKB 85-89 mmHg olan (yüksek-normal) bireyler 3.Gruba, SKB 140-159 mmHg ve/veya DKB 90-99 mmHg olan bireyler 4.Gruba, SKB 160-179 mmHg ve/veya DKB 100-109 mmHg olan bireyler 5.Gruba ve SKB≥180 mmHg ve/veya DKB≥110 mmHg olan bireyler 6.Gruba alındı. Tüm gruplarda karotis distensibilitesi ve elastisitesi ölçülerek gruplar arasında fark olup olmadığı ve eğer fark var ise hangi kan basıncı değerinden itibaren bu farkın oluşmaya başladığı değerlendirildi.
Bulgular: Tüm gruplar arasında karotis distensibilitesi ve elastisitesi yönünden istatistiksel anlamlı fark vardı (p<0.001, her iki değer için). Grup 2 ve 1 arasında anlamlı fark saptanmadı (p>0.05) ancak grup 3 ile 1 arasında anlamlı fark vardı (p<0.05). SKB>135,5 mmHg olmasının%78,2 sensitivite, %74,6 spesifite, DKB>86,5 mmHg olmasının %79,3 sensitivite ve %71,6 spesifite ile karotis distensibilitesini etkilemeye başladığı bulundu. Benzer olarak SKB>137,5 mmHg olmasının %80,4 sensitivite, %73,1 spesifite, DKB>88,5 mmHg olmasının ise %79,1 sensitivite ve %73,8spesifite ile karotis elastisitesini etkilemeye başladığı gösterildi.
Sonuç: Karotis distensibilitesi ve elastisitesi kan basıncının artışı ile azalmaktadır. Yüksek-normal kan basıncına sahip bireylerde belirli bir kan basıncı değerinden sonra karotis hasarı başlıyor olabilir.

Keywords

Doppler, hipertansiyon, kan basıncı

Project Number

KA19/339

Blood pressure limits affecting carotid artery injury: a cross sectional study

Abstract

Objective: Although it is well known that high blood pressure causes undesirable effects on carotid arteries, it is not clear as to which threshold value this effect starts. The aim of this study is to evaluate and determine this threshold.
Materials and Methods: This cross-sectional study included a total of 308 individuals in the following groups; Group 1: individuals with systolic blood pressure (SBP) <120 mmHg and diastolic blood pressure (DBP) <80 mmHg (optimal), Group 2: SBP 120-129 mmHg and/or DBP 80-84 mmHg (normal), Group 3: SBP 130-139 mmHg and/or DBP 85-89 mmHg (high-normal), Group 4: SBP 140-159 mmHg and/or DBP 90-99 mmHg, Group 5: SBP 160-179 mmHg and/or DBP 100-109 mmHg, and Group 6: SBP≥180 mmHg and/or DBP≥110 mmHg. Carotid distensibility and elasticity were measured in all groups.
Results: A statistically significant difference was determined between the groups in carotid distensibility and elasticity (p<0.001, for both values). There was no significant difference between groups 2 and 1 (p>0.05), but there was a significant difference between other groups (groups 3-4-5) and group 1 (p<0.05, for all comparisons). SBP>135.5 mmHg started to affect carotid distensibility with 78.2% sensitivity and 74.6% specificity, and DBP>86.5 mmHg with 79.3% sensitivity and 71.6% specificity. Carotid elasticity was seen to be affected by SBP>137.5 mmHg with 80.4% sensitivity and 73.1% specificity, and DBP>88.5 mmHg with 79.1% sensitivity and 73.8% specificity.
Conclusion: Carotid distensibility and elasticity decreases with increasing blood pressure. In individuals with high-normal blood pressure, carotid damage may begin after a certain blood pressure value.

Keywords

Blood pressure, Carotid artery, , Doppler

Supporting Institution

Başkent Üniversitesi

Project Number

KA19/339

Thanks

Dear Editor; Please find our report entitled “Blood Pressure Limits Affecting Carotid Artery Injury. A Cross Sectional Study”. We hope you will find our report interesting for reviewing and publishing it in your esteemed Journal. This report had not been published before or is not under review elsewhere. None of the paper’s contents have previously published. All authors have read and approved the manuscript. On behalf of all the contributors I will act and guarantor and will correspond with the journal from this point onward. All authors declare that they have no conflicts of interest. The authors have indicated they have no financial relationships relevant to this article to disclose. This study was approved by Baskent University Institutional Review Board and Ethics Committee and supported by Baskent University Research Funding (KA19/339). Yours sincerely, Aylin Güneşli MD, Baskent University, Department of Radiology, Yuregir, Adana, Turkey 03-11-2020

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