Akut romatizmal ateşi taklit eden Castleman hastalığı

Year 2021, Volume: 46 Issue: 2, 877 - 879, 30.06.2021

Kazım Öztarhan , Yusuf Ziya Varlı , Gülçin Yegen

Abstract

Anjiyofoliküler lenf nodu hiperplazisi veya dev lenf nodu hiperplazisi olarak da bilinen Castleman hastalığı (CH), etiyolojisi tam olarak bilinmeyen ve nadir görülen benign bir hastalıktır. Erişkinlerde daha sıktır ancak çocukluktan itibaren her yaşta görülebilir. Sıklıkla toraksa yerleşmekle beraber tüm vücutta bulunabilir. Histolojik olarak hiyalin vasküler ve plazma hücreli varyant olarak sınıflandırılır. Lokalize (unisentrik) hastalığı olan olguların çoğu hiyalin vasküler, multisentrik hastalığı olan olguların çoğu ise plazma hücreli histolojik tipindedir.
Burada, başlangıçta akut romatizmal ateş tanısı alan, ancak hastanede yatarken incelendiğinde nadir histolojik varyant olan plazma hücreli tipte CH olduğu tespit edilen 6 yaşında bir kız çocuğu sunuyoruz.

Keywords

Castleman hastalığı, lenfadenopati, cerrahi

Castleman's disease mimicking acute rheumatic fever

Abstract

Castleman’s disease (CD), also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia, is a rare benign disease with an unknown etiology. It is more common in adults, but can be seen at all ages from childhood. Although it is often located in the thorax, it can be found throughout the body. Histologically classified as hyaline vascular and plasma cell variant. Most of unicentric disease is hyalin vascular and most of multicentric disease is plasma cell type histologically.
We report the case of a 6-year-old girl who was diagnosed with acute rheumatic fever at the beginning, but was found to be histologically rare plasma cell variant CD when examined during hospitalization.

Keywords

Castleman’s disease, lymphadenopathy, surgery

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