C-reaktif protein/albümin oranı COVID-19 pnömonisi olan hastalarda artan mortalite riski ile ilişkilidir

Year 2021, Volume: 46 Issue: 4, 1449 - 1458, 30.12.2021

Selen Acehan , Müge Gülen , Cem Isikber , Adem Kaya , Nurdan Unlu Cagdas Ince Basak Toptas Firat , Gonca Koksaldı Hilmi Erdem Sümbül , Salim Satar

https://doi.org/10.17826/cumj.977050

Cited By: 6

Abstract

Amaç: Bu retrospektif gözlemsel çalışmanın amacı, COVID-19 pnömonisi nedeniyle hastaneye yatırılan 18 yaş üstü hastalarda mortaliteyi öngörme açısından acil serviste bakılan C-reaktif protein/albumin oranı ile CURB-65 skorunun karşılaştırılmasıdır.
Gereç ve Yöntem: Çalışma 15 Mart-30 Nisan 2020 tarihleri arasında acil servis pandemi alanında toraks bilgisayarlı tomografisinde COVID-19 pnömonisi tespit edilerek hastaneye yatırılan 613 hastayı kapsamaktadır. Hastanede yatan hastalar pozitif ve negatif gerçek zamanlı polimeraz zincir reaksiyonu sonuçlarına göre gruplara ayrıldı.
Bulgular: Çalışmaya dahil edilen 613 hastanın %73,1'i (n:448) serviste yatarken, %26,9'u (n:165) yoğun bakımda yatmaktaydı. Toplam hastaların %8,6'sı (n:53) öldü. Ölen hastalarda CURB 65 skoru ortalama 4±1 ve C-reaktif protein/albümin oranı 5.6±4.2 idi.. Çok değişkenli lojistik regresyon analizi, CURB 65 skorunu) ve yüksek C-reaktif protein/albümin oranı olduğunu gösterdi.) COVID-19 pnömonisi için bağımsız risk faktörleri olarak göstermiştir.
Sonuç: C-reaktif protein/albumin oranı, kötü prognozlu COVID-19 pnömonisi olan hastaların erken tespitinde CURB 65 kadar duyarlı olup klinisyene yol gösterebilir.

Keywords

Acil Servis, CRP/Albümin Oranı, Covid-19, CURB 65, Pnömoni

C-reactive protein to albumin ratio is associated with increased risk of mortality in COVID-19 pneumonia patients

Abstract

Purpose: The aim of this retrospective observational study is to compare C-reactive protein to albumin ratio and CURB-65 score in the emergency department in terms of predicting mortality in patients over the age of 18 who were hospitalized for COVID-19 pneumonia.
Materials and Methods: The study includes 613 patients hospitalized between March 15 and April 30, 2020 due to COVID-19 pneumonia detected on thorax computed tomography at the emergency department pandemic area. Hospitalized patients were divided into groups according to positive and negative real-time polymerase chain reaction results.
Results: While 73.1% (n: 448) of 613 patients included in the study were hospitalized in the ward, 26.9% (n: 165) were hospitalized in intensive care. 8.6% (n: 53) of the total patients died. In non-survivors patients the mean CURB 65 score was 4±1 (and C-Reactive Protein to Albumin Ratio was 5.6±4.2 Multivariate logistic regression analysis showed that CURB 65 and high C-Reactive Protein to Albumin Ratio are independent risk factors for COVID-19 pneumonia.
Conclusion: The C-reactive protein to albumin ratio is as sensitive as CURB 65 and can guide the clinician in the early detection of patients with poor prognosis COVID-19 pneumonia.

Keywords

CRP/Albumine Ratio, Covid-19, CURB 65, Emergency Department, Pneumonia

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