Serum uric acid levels in borderline personality disorder and its relationship with impulsivity

Year 2021, Volume: 46 Issue: 4, 1624 - 1631, 30.12.2021

Aslı Kazğan , Sevler Yıldız , Osman Kurt , Sevda Korkmaz

https://doi.org/10.17826/cumj.999393

Cited By: 1

Abstract

Purpose: The aim of this study is to investigate the serum uric acid levels in patients diagnosed with borderline personality disorder (BPD) who do not use drugs and explore their possible relationship with impulsivity.
Materials and Methods: Sixty-nine patients diagnosed with BPD and 54 healthy controls were enrolled in this study. All participants were administered a sociodemographic data form and the Barratt Impulsivity Scale Short Form (BIS-11). Subsequently, fasting venous blood samples were collected from all participants and serum uric acid levels were studied.
Results: It was found that serum uric acid levels, BDI-11 subdimension and total scores, and the BDI total score were significantly higher in patients diagnosed with BPD than in the control group. A significant positive correlation was seen between serum uric acid levels and the BDI-11 scale score.
Conclusion: This study report higher serum uric acid levels in patients diagnosed with borderline personality disorder who do not use drugs compared to the control group. The results of this study may provide an example that impulsivity in patients diagnosed with borderline personality disorder has a biological basis. Future longitudinal and experimental studies of uric acid levels in BPD patients will allow us an alternative way to diagnose and treat impulsivity in these patients.

Keywords

Borderline personality disorder, impulsivity, uric acid

Sınırda kişilik bozukluğunda serum ürik asit seviyeleri ve dürtüsellikle ilişkisi

Abstract

Amaç: Çalışmanın amacı ilaç kullanımı olmayan sınırda kişilik bozukluğu (SKB) tanılı hastalardaki serum ürik asit seviyelerini incelemek ve bunun dürtüsellikle olabilecek olası ilişkisini araştırmaktır.
Gereç ve Yöntem: Bu çalışmaya SKB tanılı 69 hasta ve 54 sağlıklı kontrol grubu dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Barratt Dürtüsellik Ölçeği Kısa Formu (BDÖ-11) uygulanmıştır. Ardından tüm katılımcılardan açlık venöz kan örnekleri alınarak serum ürik asit düzeyleri çalışılmıştır.
Bulgular: SKB tanılı hastalarda serum ürik asit seviyeleri, BDÖ-11 alt boyut ve toplam puanları ve BDÖ toplam puanı kontrol grubundan anlamlı şekilde yüksek bulunmuştur. Serum ürik asit seviyeleri ile BDÖ-11 ölçek puanı arasında pozitif yönde anlamlı bir korelasyon olduğu görülmüştür.
Sonuç: Bu çalışmada, ilaç kullanımı olmayan sınırda kişilik bozukluğu tanılı hastalarda kontrol grubuna göre daha yüksek serum ürik asit seviyelerini bildirilmiştir. Çalışmanın bulguları SKB tanılı hastalardaki dürtüselliğin biyolojik temellere dayandırılması açısından örnek oluşturabilir. SKB hastalarında ürik asit seviyeleri ile ilgili ileride yapılacak olan uzunlamasına ve deneysel çalışmalar bizlere bu hastalardaki dürtüselliğin tanı ve tedavisi açısından alternatif bir yol gösterecektir.

Keywords

dürtüsellik, kişilik bozukluğu, ürik asit

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