Safety and efficacy of chemoembolization with mixture of bleomycin and lipiodol in the treatment of giant liver hemangiomas

Year 2022, Volume: 47 Issue: 1, 310 - 321, 31.03.2022

Umur Anıl Pehlivan , Tuğsan Ballı , Kairgeldy Aikimbaev

https://doi.org/10.17826/cumj.1035544

Cited By: 1

Abstract

Purpose: The aim of this retrospective observational study was to evaluate the safety and efficacy of transarterial chemoembolization (TACE) therapy with a mixture of bleomycin and lipiodol used in the treatment of giant liver hemangiomas.
Materials and Methods: Twenty-one patients with a total of 24 giant liver hemangiomas treated with TACE using a mixture of bleomycin and lipiodol between October 2014 to January 2020 were included in this study. Dimension, volume, and compression findings prior to and after the procedure were recorded..
Results: Twenty-four hemangiomas in 21 patients (14 [66,6%] female) were statistically investigated. The median age was 47 years (min-max: 35-69 years). Post-TACE median follow-up was 26.2 months (min-max: 5.5-48.5 months). In all but two patients, a single session TACE was performed. The median dimension of giant hemangiomas was 96 mm (min-max: 41-120 mm) and 61 ml (min-max: 20-120 mm) before and after TACE respectively. Median volume was 240.79 ml (13.13-2628.62 ml) and 61 ml (3.02-831.16 ml) before and after TACE respectively. There was a statistically significant reduction in both dimension and volume. There was no major complication.
Conclusion: Transarterial chemoembolization with a mixture of bleomycin and lipiodol is a safe method due to the low complication rate. Due to the fact that it significantly reduces the size of giant hemangiomas, it is an effective method. It may be an alternative in patients with giant hemangioma for whom surgical treatment is not appropriate.

Keywords

Liver, giant hemangioma, Bleomycin, Lipiodol, transarterial chemoembolization

Karaciğer dev hemanjiyomlarinin tedavisinde bleomisin ve lipiodol karışımı ile kemoembolizasyonun güvenilirliği ve etkinliği

Abstract

Amaç: Bu retrospektif gözlemsel çalışmanın amacı, karaciğer dev hemanjiyomlarının tedavisinde uygulanan bleomisin ve lipiodol karışımı ile transarteryal kemoembolizasyon (TAKE) tedavisinin güvenilirliğini ve etkinliğini değerlendirmekti.
Gereç ve Yöntem: Bu çalışmaya Ekim 2014 ile Ocak 2020 tarihleri arasında bleomisin ve lipiodol karışımı ile TAKE uygulanan ve takip edilen 24 dev hemanjiyomu olan ardışık 21 hasta dahil edilmiştir. Tüm hastaların işlem öncesi ve sonrası dev hemanjiyom boyutları, hacimleri, bası bulguları not edilmiştir..
Bulgular: Bu çalışmada tedavi uygulanmış toplam 24 hemanjiyomu olan 21 hasta (14’ü [%66.6] kadın) istatistiksel olarak değerlendirilmiştir. Hastaların medyan yaşı 47’dir (min-max: 35-69 yaş). Hastaların TAKE sonrası medyan takip süresi, 26.2 aydır (min-max: 5.5-48.5 ay). İki hasta dışında tüm hastalara tek seans TAKE uygulandı. Dev hemanjiyomların medyan boyutu, TAKE öncesi 96 mm (min-max: 41-210 mm), TAKE sonrası 61 mm’dir (min-max: 20-120 mm). Dev hemanjiyomların TAKE öncesi medyan hacmi 240.79 ml (min-max: 13.13-2628.62 ml); TAKE sonrası 61 ml’dir (min-max: 3.02-831.16 ml). Hem boyut hem de hacimsel azalma istatistiksel olarak anlamlı bulundu. Herhangi bir majör komplikasyon gözlemlenmedi
Sonuç: Bleomisin ve lipiodol karışımı ile TAKE düşük komplikasyon oranı nedeniyle güvenilir bir yöntemdir. Dev hemanjiyomlarda anlamlı ölçüde küçülme sağlaması nedeniyle, etkin bir yöntemdir. Cerrahi tedavinin uygun olmadığı dev hemanjiyomlu hastalarda alternatif olabilir.

Keywords

Karaciğer, dev hemanjiyom, Bleomisin, Lipiodol, transarteryal kemoembolizasyon

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