Predictive value of systemic immune-inflammation index in patients with preterm labor

Year 2022, Volume: 47 Issue: 2, 697 - 703, 30.06.2022

Zekiye Soykan Sert , Ramazan Bülbül

https://doi.org/10.17826/cumj.1089119

Cited By: 5

Abstract

Purpose: The aim of this study was to investigate whether the systemic immune-inflammatory index (SII) could predict the development of preterm labor in pregnant women.
Materials and Methods: Pregnant women aged 18 years and over who presented to our clinic with spontaneous labor between January 1, 2018, and December 31, 2021, had intact membranes, and had a single living fetus were retrospectively evaluated. The women were divided into two groups, preterm and term delivery, according to the week of delivery. The clinical and laboratory characteristics of the women were assessed. The patients’ platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and SII (neutrophil count x platelet count/lymphocyte count) were calculated.
Results: The study included 171 women with preterm labor and 173 women with healthy term labor. The PLR, NLR, and SII values were statistically significantly higher in the preterm group than in the term group. The multivariate logistic regression analysis showed that SII (odds ratio [OR]: 3.65, 95% confidence interval [CI]: 2.21–10.07) was an independent predictor of the development of preterm labor. We found that the power of SII to predict preterm labor (area under the curve [AUC]: 0.792) was higher than that of NLR (AUC: 0.725) or PLR (AUC: 0.716) alone. SII values higher than 789.3 predicted preterm labor with 68.4% sensitivity and 81.5% specificity.
Conclusion: We found that SII was more valuable than NLR and PLR in the early detection of preterm labor. SII can help identify pregnant women at risk of developing preterm labor in the early stages of pregnancy.

Keywords

Systemic immune-inflammation index, preterm labor, pregnancy

Erken doğum yapan kadınlarda sistemik immün-inflamasyon indeksinin prediktif değeri

Abstract

Amaç: Bu çalışmada sistemik immün-inflamatuar indeksin (SII) hamile kadınlarda erken doğum gelişimini tahmin edip edemeyeceği araştırılmıştır.
Gereç ve Yöntem: 1 Ocak 2018-31 Aralık 2021 tarihleri arasında kliniğimize spontan doğum eylemi ile başvuran, membranları intakt olan ve tek canlı fetüsü olan 18 yaş ve üstü gebeler retrospektif olarak değerlendirildi. Kadınlar doğum haftasına göre preterm ve term doğum olmak üzere iki gruba ayrıldı. Kadınların klinik ve laboratuvar özellikleri değerlendirildi. Hastaların trombosit-lenfosit oranı (PLR), nötrofil-lenfosit oranı (NLR) ve SII (nötrofil sayısı x trombosit sayısı/lenfosit sayısı) hesaplandı.
Bulgular: Çalışmaya erken doğum yapan 171 kadın ve sağlıklı term doğum yapan 173 kadın dahil edildi. PLR, NLR ve SII değerleri preterm grupta term grubuna göre istatistiksel olarak anlamlı derecede yüksekti. Çok değişkenli lojistik regresyon analizi, SII'nin (olasılık oranı [OR]: 3.65, %95 güven aralığı [GA]: 2.21–10.07) erken doğum gelişiminin bağımsız bir prediktör olduğunu gösterdi. SII'nin erken doğumu (eğrinin altındaki alan [AUC]: 0.792) tahmin etme gücünün, tek başına NLR (AUC: 0.725) veya PLR'den (AUC: 0.716) daha yüksek olduğunu bulduk. 789.3'ün üzerindeki SII değerleri, %68,4 duyarlılık ve %81.5 özgüllük ile erken doğumu öngördü.
Sonuç: Preterm doğumun erken tespitinde SII’nın NLR ve PLR’den daha değerli olduğunu bulduk. SII, preterm doğum gelişme riski taşıyan gebelerin erken dönemde belirlenmesine yardımcı olabilir.

Keywords

Sistemik immün-inflamatuar indeks, erken doğum, gebelik

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