Relationship of restless legs syndrome with blood parameters

Year 2022, Volume: 47 Issue: 2, 776 - 782, 30.06.2022

Murat Güntel , Alper Uysal , Ismet Melek

https://doi.org/10.17826/cumj.1091685

Abstract

Purpose: We aimed to investigate the factors affecting the etiopathogenesis by comparing the restless legs syndrome patients with the healthy control group in terms of some laboratory parameters.
Materials and Methods: Patients who were diagnosed with restless legs syndrome were included in the study. A control group that was similar in terms of age and gender was formed. Both groups were compared in terms of iron, ferritin, iron-binding capacity, folate, vitamin B12, vitamin D, calcium, magnesium, ALT, AST, hemogram, creatinine, fasting blood sugar, and thyroid hormone levels.
Results: 37 patients with restless legs syndrome and 41 controls were included in the study. In the restless legs syndrome group hemoglobin, ferritin, iron, fasting blood sugar, vitamin D, and fT4 values were 12.7 (10.3-16.0) g/dL, 37.3 (3.7-89.4) mg/L, 62 (21-195) μg/dL, 96 (65-250) mg/L, 11.26 (4.20-41.57) ug/L and 1.24 (0.73-2.14) µg/dL respectively, they were 14.8 (12.3-16.1) g/dL, 56 (9-189) mg/L, 90 (30-245) µg/dL, 91 (70-107) mg/L, 17.31 (5.73-32.90) µg/L and 1.08 (0.63-2.04) µg/dL respectively in the control group.There were statistically significant differences between the groups in terms of hemoglobin, ferritin, iron, fasting blood sugar, vitamin D, and fT4 levels.
Conclusion: Hemoglobin and iron parameters, vitamin D levels, fasting blood sugar and T4 levels should be evaluated in patients with restless legs syndrome and should be replaced if necessary. Correction of deficiencies may be beneficial for patients' clinics.

Keywords

Restless Legs Syndrome, Iron Parameters, vitamin D

Huzursuz bacak sendromunun kan parametreleri ile olan ilişkisi

Abstract

sağlıklı kontrol grubu ile bazı laboratuvar parametreleri açısından karşılaştırarak etyopatogenezi etkileyen faktörleri araştırmak amaçlanmıştır.
Gereç ve Yöntem: Huzursuz bacak sendromu tanısı konulan hastalar çalışmaya dahil edildi. Yaş ve cinsiyet açısından benzer kontrol grubu oluşturuldu. Her iki grup demir, ferritin, demir bağlama kapasitesi, folat, vitamin B12, vitamin D, kalsiyum, magnezyum, ALT, AST, hemogram, kreatinin, açlık kan şekeri, tiroid hormon seviyeleri açısından karşılaştırıldı.
Bulgular: Çalışmaya 37 huzursuz bacak sendromu hastası, 41 tane de kontrol dahil edildi. Huzursuz bacak sendromu grubunda hemoglobin, ferritin, demir, açlık kan şekeri, D vitamini ve fT4 değerleri sırasıyla 12.7 (10.3-16.0) g/dL, 37.3 (3.7-89.4) mg/L, 62 (21-195) μg/dL, 96 (65-250) mg/L, 11.26 (4.20-41.57) ug/L ve 1.24 (0.73-2.14) µg/dL iken kontrol grubunda sırasıyla 14.8 (12.3-16.1) g/dL, 56 (9-189) mg/L, 90 (30-245) µg/dL, 91 (70-107) mg/L, 17.31 (5.73-32.90) µg/L ve 1.08 (0.63-2.04) µg/dL idi. Hemoglobin, ferritin, demir, açlık kan şekeri, vitamin D ve T4 seviyeleri açısından gruplar arasında istatistiksel olarak anlamlı farklılıklar saptandı.
Sonuç: Huzursuz bacak sendromlu hastalarda hemoglobin ve demir parametreleri, vitamin D düzeyleri, açlık kan şekeri ve T4 seviyeleri eksiklikleri açısından mutlaka değerlendirilmeli, gereklilik halinde mutalaka replase edilmelidir. Eksikliklerin düzeltilmesi hastaların klinikleri açısından yararlı olabilir.

Keywords

Huzursuz bacak sendromu, Demir parametreleri, d vitamini

References

• 1. Klingelhoefer L, Bhattacharya K, Reichmann H. Restless legs syndrome. Clinical Medicine. 2016;16(4):379.
• 2. Zintzaras E, Kitsios GD, Papathanasiou AA, et al. Randomized trials of dopamine agonists in restless legs syndrome: a systematic review, quality assessment, and meta-analysis. Clinical therapeutics. 2010;32(2):221-237.
• 3. Sayin S, Atilla FD. Demir Eksikliğinin Gözden Kaçan Klinik Prezantasyonu; Huzursuz Bacak Sendromu. Ankara Medical Journal. 2019;19(3):694-697.
• 4. Üçgün AB, Kilit TP, Onbaşı K. DİYABETİK HASTALARDA HUZURSUZ BACAK SENDROMU SIKLIĞI VE İLİŞKİLİ FAKTÖRLERİN ARAŞTIRILMASI. PREVALENCE. 2019;30:38.
• 5. Ohayon MM, O’Hara R, Vitiello MV. Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep medicine reviews. 2012;16(4):283-295.
• 6. Taşdemir M, Erdoğan H, Börü ÜT, Dilaver E, Kumaş A. Epidemiology of restless legs syndrome in Turkish adults on the western Black Sea coast of Turkey: A door-to-door study in a rural area. Sleep medicine. 2010;11(1):82-86.
• 7. Sayin S, Atilla F. Overlooked clinical presentation of iron deficiency; Restless Leg Syndrome. Ankara Med J. 2019:19-13.
• 8. Ulfberg J, Nyström B, Carter N, Edling C. Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Movement disorders: official journal of the Movement Disorder Society. 2001;16(6):1159-1163.
• 9. Benediktsdottir B, Janson C, Lindberg E, et al. Prevalence of restless legs syndrome among adults in Iceland and Sweden: lung function, comorbidity, ferritin, biomarkers and quality of life. Sleep medicine. 2010;11(10):1043-1048.
• 10. Ekbom K-A. Restless legs syndrome. Neurology. 1960;10(9):868-868.
• 11. Matthews W. Iron deficiency and restless legs. British medical journal. 1976;1(6014):898.
• 12. O'keeffe S, Gavin K, Lavan J. Iron status and restless legs syndrome in the elderly. Age and ageing. 1994;23(3):200-203.
• 13. Guo S, Huang J, Jiang H, et al. Restless legs syndrome: from pathophysiology to clinical diagnosis and management. Frontiers in Aging Neuroscience. 2017;9:171.
• 14. Moon H-J, Chang Y, Lee YS, et al. T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early-and late-onset restless legs syndrome. Journal of Clinical Neurology. 2014;10(3):197-202.
• 15. Katsanos A, Kosmidou M, Konitsiotis S, et al. Restless legs syndrome and cerebrovascular/cardiovascular events: systematic review and meta‐analysis. Acta neurologica scandinavica. 2018;137(1):142-148.
• 16. Wali S, Shukr A, Boudal A, Alsaiari A, Krayem A. The effect of vitamin D supplements on the severity of restless legs syndrome. Sleep and breathing. 2015;19(2):579-583.
• 17. Atalar AÇ. Huzursuz Bacaklar Sendromunda 25 (OH) Vitamin D Düzeylerinin Hastalık Şiddeti ve Uyku Kalitesi ile Olan İlişkisi. Turk Noroloji Dergisi. 2019;25(2):87.
• 18. Högl B, Kiechl S, Willeit J, et al. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology. 2005;64(11):1920-1924.