COVID-19 pnömonili hastalarda yaşa bağımlı bir prognostik faktör olarak CRP/albümin oranı

Year 2022, Volume: 47 Issue: 3, 1239 - 1247, 30.09.2022

Tuğçe Şahin Özdemirel , Esma Sevil Akkurt , Özlem Ertan , Derya Yenibertiz , Berna Akıncı Özyürek

https://doi.org/10.17826/cumj.1133756

Abstract

Amaç: Çalışmamızın amacı, Covid-19 pnömonisinde C-reaktif protein/albüminin yaşa bağlı bir belirteç olup olmadığını belirlemekti.
Gereç ve Yöntem: Covid-19 pnömonisi olan 296 (166 erkek/ 130 kadın) hasta üzerinde retrospektif bir araştırma yaptık. Katılımcılar <65 ve ≥65 yaş olmak üzere iki gruba ayrıldı. Yoğun bakım yatışı, pulse steroid ihtiyacı ve ölüm oranları C-Reaktif protein/albümin oranı kullanılarak karşılaştırıldı.
Bulgular: CRP/albümin oranı; yoğun bakım ünitesi ve kliniğe alınan 65 yaş üstü ve 65 yaş altı hastalarda istatistiksel olarak yüksekti ve 65 yaş ve üzeri hastalarda mortaliteyi göstermede anlamlı bulundu. Tek değişkenli regresyon analizine göre C-reaktif protein/albümin oranı hem 65 yaş altı hem de 65 yaş üstü hastalarda yoğun bakıma yatış riski için istatistiksel olarak anlamlı idi (sırasıyla OR:1.515 ve OR:1,357). Çok değişkenli analize göre ise CRP/albümin oranı 65 yaş üstü hastalarda istatistiksel olarak anlamlı bulundu (OR: 1.209).
Sonuç: Artmış CRP/albümin oranının Covid-19 ciddiyeti, hastanede kalış süresi ve ölüm oranlarını tahmin etmede faydalı olduğu düşünülmektedir. Bu değişken kolay hesaplanabilir ve yaştan bağımsız olarak Covid-19 hastalarının klinik seyrini tahmin etmek için kullanılabilir.

Keywords

albumin, Covid-19, C-reaktif protein, pnömoni

Supporting Institution

YOK

Project Number

YOK

Thanks

YOK

CRP/albumin ratio as an age-dependent prognostic factor in patients with COVID-19 pneumonia

Abstract

Purpose: The aim of our study was to determine whether C-reactive protein/albumin is an age-related marker in Covid-19 pneumonia.
Materials and Methods: We performed a retrospective research on 296 patients (166 male/130 female) with Covid-19 pneumonia. The participants were divided into two groups as <65 and ≥65 years of age. The need of intensive care unit, pulse steroid requirement and mortality rates were all compared using the The C-reactive protein/albumin ratio.
Results: The C-reactive protein/albumin was found to be high in patients over the age of 65 as well as those under the age of 65 who were admitted to the intensive care unit and was found to be significant in demonstrating mortality in patients aged 65 and over. According to univariate analysis, the C-reactive protein/albumin ratio was statistically significant for the risk of intensive care admission in both patients under 65 and over 65 years of age (OR:1.515 and OR:1.357, respectively). According to multivariate analysis, the CRP/albumin ratio was statistically significant for the risk of intensive care admission, only in patients over the age of 65 (OR:1.209).
Conclusion: The increased C-reactive protein/albumin levels are thought to be useful in predicting the severity of Covid-19, hospitalisation time, and mortality rates. This variable can be calculated and used to predict the clinical course of Covid-19 pneumonia without regard to age.

Keywords

C-reactive protein, albumin, Covid-19, pneumonia

Project Number

YOK

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