Stabil idiyopatik pulmoner fibrozde hastalik şiddeti ve prognostik belirteçler ile matriks metallaproteinaz düzeyleri arasindaki ilişki

Year 2022, Volume: 47 Issue: 3, 1273 - 1280, 30.09.2022

Oya Baydar Toprak , Ezgi Özyılmaz , Yasemin Saygideger , Efraim Güzel

https://doi.org/10.17826/cumj.1137742

Abstract

Amaç: Biyobelirteçler, son zamanlarda idiyopatik pulmoner fibrozis (İPF) olası tanısında prognostik göstergeler olarak kapsamlı bir şekilde değerlendirilmektedir. Yaygın IPF klinik uygulamasında dolaşımdaki biyobelirteçlerin değerini belirleyebilmek için bu çalışma, stabil idiyopatik pulmoner fibrozlu hastalarda hastalık şiddeti, prognostik göstergeler ve serum matriks metalloproteinaz arasındaki bağlantıya ilişkin sonuçlar çıkarmayı amaçlamaktadır.
Gereç ve Yöntem: Çalışma, multidisipliner bir yaklaşımla doğrulanmış İPF tanısı olan 22 kişiden oluşuyordu. Sosyodemografik detaylar, klinik ve radyolojik semptomlar, solunum fonksiyon testleri ve GAP skoru kaydedildi. Serum MMP konsantrasyonları ELISA yöntemiyle ölçülmüştür.
Bulgular: Matriks Metalloproteinaz (MMP) 2, MMP 7, MMP 9 ve MMP13 ile GAP indeksi ve solunum fonksiyon testleri veya hastalık şiddeti arasında istatistiksel olarak anlamlı bir ilişki yoktur. GAP skoru ağır hastalığı olanlarda evre 3'te, orta hastalığı olanlarda evre 2'de, hafif hastalığı olanlarda evre 1'de daha yüksek bulundu.
Sonuç: MMP ile İPF prognostik belirteçleri, solunum fonksiyon testleri ve hastalık şiddeti arasındaki ilişki bu incelemede görülmemesine rağmen literatürde tutarlı bulgular mevcuttur. Ancak, son teknoloji bir tedavi stratejisine kapı açabilecekleri için, bu göstergeler daha geniş serilerde ileriye dönük olarak araştırılmalıdır.

Keywords

idiopatik pulmoner fibrozis, matrix metalloproteinaz, gap, ciddiyet, biyomarker

Supporting Institution

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Thanks

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Relationship between disease severity and prognostic indicators and matrix metallaproteinase in patients with stable idiopatic pulmonary fibrosis

Abstract

Purpose: Blood-derived biomarkers have been extensively considered as possible prognostic indicators in idiopathic pulmonary fibrosis (IPF) recently. In order to assess the value of circulating biomarkers in common IPF clinical practice, the study intends to draw conclusions regarding the link between disease severity, prognostic indicators, and serum matrix metalloproteinase in patients with stable idiopathic pulmonary fibrosis.
Materials and Methods: The study comprised 22 people with an IPF diagnosis that had been verified by a multidisciplinary approach. The sociodemographic details, clinical and radiologic symptoms, pulmonary function tests and the Gender-Age-Physiology (GAP) score were noted. ELISA has been used to research serum MMP concentrations.
Results: There is no statistically significant correlation between the Matrix Metalloproteinase (MMP) 2, MMP 7, MMP 9, and MMP13 and the GAP index and, pulmonary function tests, or disease severity. GAP score was found to be higher in stage 3 in patients with severe disease, in stage 2 in patients with moderate disease, and in stage 1 in patients with mild disease.
Conclusion: There are consistent findings in the literature, despite the fact that the association between MMP and IPF prognostic markers, pulmonary function tests, and disease severity could not be seen in this investigation. However, because they could open the door to a cutting-edge treatment strategy, these indicators should be investigated prospectively in larger series.

Keywords

idiopathic pulmonary fibrosis, matrix metalloproteinases, gap, severity, biomarkers

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