Research Article
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Folik asit takviyesinin antenatal ve postnatal dönemde ruh sağlığına etkisi

Year 2022, Volume: 47 Issue: 4, 1547 - 1557, 28.12.2022
https://doi.org/10.17826/cumj.1167060

Abstract

Amaç: Çalışmanın amacı folik asit takviyesi kullanımının antenatal ve postnatal dönemde ruh sağlığına etkisini incelemek.
Gereç ve Yöntem: Tanımlayıcı-prospektif boylamsal tipte olan çalışma, 1 Aralık 2019-30 Ocak 2021 tarihleri arasında Türkiye'nin doğusundaki bir Aile Sağlığı Merkezinde yapıldı. Çalışma gebelikte, doğum sonrası 6-8. hafta ve doğum sonrası 6. ay olmak üzere üç aşamada tamamlandı. Çalışmaya toplam 162 sağlıklı gebe dahil edildi. Verilerin toplanmasında Kişisel Bilgi Formu, Beck Anksiyete Envanteri (BAI) ve Edinburgh Doğum Sonrası Depresyon Ölçeği (EPDS) kullanıldı.
Bulgular: Katılımcıların %32.7'si (n=53) gebelik öncesi dönemden başlayıp gebeliğin ilk trimesterinde de (6 ay) FA takviyesi kullanmış ve %34.6'sı (n=56) FA takviyesini sadece gebeliğin ilk trimesterinde kullanmıştır. Katılımcıların %32.7'sinin (n=53) herhangi bir FA takviyesi kullanmadığı belirlendi. FA kullanmayanların %37.0’I antenatal dönemde, %50.8’i postnatal 6-8. haftalarda hafif/orta/şiddetli düzeyde anksiyete yaşadığı belirlendi. 6 ay süreyle FA takviyesi kullananlarda doğum öncesi, doğum sonrası 6-8 hafta ve doğum sonrası 6 ayda BAI ve EPDS puanları en düşüktü. BAI ve EPDS puanlarının antenatal, postnatal 6-8 hafta ve postnatal 6. ayda istatistiksel olarak azaldığı belirlendi.
Sonuç: Araştırma bulguları, antenatal ve postnatal dönemde FA takviyesi kullanımının anksiyete ve depresyon belirtilerini önlemede etkili olabileceğini ortaya koymuştur.

Supporting Institution

Yok

Project Number

yok

References

  • World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization, 2016.
  • Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, et al. Folic acid supplementation for the prevention of neural tube defects: US Preventive Services Task Force recommendation statement. JAMA 2017;317:183–9.
  • World Health Organization. (2017). Global diffusion of eHealth: making universal health coverage achievable: report of the third global survey on eHealth. World Health Organization.
  • Güler B, Bilgiç D, Okumuş H, Yağcan H. Gebelikte beslenme desteğine ilişkin güncel rehberlerin incelenmesi. Dokuz Eylül Üniversitesi Hemşirelik Fakültesi Elektronik Dergisi 2019;12:143-151.
  • Toivonen KI, Lacroix E, Flynn M, et al. Folic acid supplementation during the preconception period: a systematic review and meta-analysis. Preventive medicine 2018;114:1-17.
  • Baykan Z, Ozturk A, Poyrazoglu S, Gun I. Awareness, knowledge, and use of folic acid among women: a study from Turkey. Archives of Gynecology and Obstetrics 2011;283:1249–1253. Basgul A, Akici A, Uzuner A, et al. Drug utilization and teratogenicity risk categories during pregnancy. Advances in Therapy 2007;24: 68–80. Özer A, Özer S, Pektaş Kanat M, et al. How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine 2016;7:538-541.
  • Yan J, Liu Y, Cao L, et al. Association between duration of folic acid supplementation during pregnancy and risk of postpartum depression. Nutrients 2017;9:1206.
  • Papakostas GI, Shelton RC, Zajecka JM, et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatr. 2012;169:1267–74.
  • Perez-Cornago A, Lopez-Legarrea P, Iglesia RDL, et al. Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic syndrome after following a weight loss treatment: the RESMENA project. Clin Nutr. 2014;33:1061–7
  • Murakami K, Sasaki S. Dietary intake and depressive symptoms: a systematic review of observational studies. Molecular nutrition & food research 2010;54: 471-488.
  • Murakami K, Mizoue T, Sasaki S, et al. Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition 2008;24:140-147.
  • Lewis SJ, Araya R, Leary S, Smith GD, Ness A. Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. Eur. J. Clin. Nutr. 2012;66: 97–103.
  • Chang F, Fan X, Zhang Y, Tang B, Jia X. Prevalence of depressive symptoms and correlated factors among pregnant women during their second and third trimesters in northwest rural China: a cross-sectional study. BMC Pregnancy and Childbirth 2022;22: 1-10
  • Van Vo T, Hoa TKD, Hoang TD. Postpartum depressive symptoms and associated factors in married women: A Cross-sectional study in Danang City. Front. Public Health 2017;5:93.
  • Gökbulut N, Bal Z. The relationship of mental well-being with healthy living awareness. Anatolian J Health Res. 2021;2:51-56
  • Hassani KF, Shiri R, Dennis CL. The prevalence of antenatal and postnatal co-morbid anxiety and depression: A meta-analysis. Psychol Med. 2017;47:2041-2053.
  • Sunay Z, Okyay E K, Gökbulut N, Uçar T. The Relationship of Postpartum Depression with Personality Traits. Journal of Inonu University Health Services Vocational School 2021;9: 219-229.
  • Dağlar G, Nur N, Bilgiç D, Kadıoğlu M. Affective Disorders in Pregnancy. Affective Disorders in Pregnancy 2015;2:27-40.
  • Ulusoy M, Şahin NH, Erkmen H. Turkish Version of The Beck Anxiety Inventory: Psychometric Properties. Journal of Cognitive Psychotherapy 1998;12:163-172.
  • Engindeniz AN, Küey L, Kültür S. The validity and reliability study of the Turkish form of the Edinburgh Postpartum Depression Scale. Spring Symposiums 1996;1:51-52.
  • Nilsen RM, Leoncini E, Gastaldi P, et al. Prevalence and determinants of preconception folic acid use: an Italian multicenter survey. Italian journal of pediatrics 2016;42: 65.
  • Toivonen KI, Lacroix E, Flynn M, et al. Folic acid supplementation during the preconception period: a systematic review and meta-analysis. Preventive medicine 2018;114:1-17.
  • Tunçel NT, Süt HK. The Effect of Anxiety, Depression and Prenatal Distress Levels in Pregnancy on Prenatal Attachment. The Journal of Gynecology - Obstetrics and Neonatology 2019;16:9-17.
  • Lewis SJ, Araya R, Leary S, Smith GD, Ness A. Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. European journal of clinical nutrition 2012; 66:97-103.
  • Ramos MI, Allen LH, Haan MN, Green R, Miller JW. Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am. J. Clin. Nutr. 2004;80:1024–1028.
  • Chong MFF, Wong JXY, Colega M, Chen LW, van Dam RM, Tan CS, et al. Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study. J. Psychiatry Res. 2014;55:110–116.
  • Blunden CH, Inskip HM, Robinson SM, Cooper C, Godfrey KM, Kendrick TR. Postpartum depressive symptoms: The B-vitamin link. Ment. Health Fam. Med. 2012;9:5–13.
  • Zhao G, Ford ES, Li C, Greenlund KJ, Croft JB, Balluz LS. Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey. Nutrition journal 2011;10:1-10.
  • Zaman FK, Özkan N, Toprak D. Depression and Anxiety in Pregnancy. Konuralp Medical Journal 2018;10: 20-25.
  • Gazzino R, Marrocco W, D'Ingianna AP, Poggiogalle E, Giusti AM, Pinto A, et al. Folic acid supplementation in Italian women during pregnancy: A cross-sectional study conducted in general practice. Nutrition 2020;79:110886.
  • Pektaş İ, Zoroğlu G, Mayda AS. The Condition of Folic Acid Knowledge, Folic Acid Awareness and Folic Acid Use at Pregnants Who Appeal to Duzce University Medical Faculty Hospital Obstetrics Clinic. Duzce Medical Journal 2017;19: 65-69.

Effect of folic acid supplementation on mental health in the antenatal and postnatal period

Year 2022, Volume: 47 Issue: 4, 1547 - 1557, 28.12.2022
https://doi.org/10.17826/cumj.1167060

Abstract

Purpose: The aim of the study was to examine the mental health outcomes of folic acid (FA) supplement use in the antenatal and postnatal periods.
Materials and Methods: This descriptive-prospective longitudinal study was conducted between 1 December 2019 and 30 January 2021 in a Family Health Center in eastern Turkey. The study was performed at one week in the postpartum period, at 6-8 weeks in the postpartum period, and at six months in the postpartum period. A total of 162 healthy pregnant women were included in the study. A Personal Information Form, the Beck Anxiety Inventory (BAI), and the Edinburgh Postpartum Depression Scale (EPDS) were used to collect data.
Results: While 32.7% (n=53) of the participants used FA supplementation from the pre-pregnancy period and in the first trimester of pregnancy (6 months in total), and 34.6% (n=56) used FA supplementation only in the first trimester of pregnancy. It was determined that 32.7% (n=53) of the participants did not use any FA supplement. Of those who did not use FA, 37.0% were in the antenatal period, and 50.8% were on the postnatal 6-8 days. It was determined that the participants experienced mild/moderate/severe anxiety in different weeks. BAI and EPDS scores were the lowest in the prenatal period, at 6-8 weeks in the postpartum period, and at 6 months in the postpartum period in those who used FA supplementation for 6 months. BAI and EPDS scores decreased significantly from the antenatal, to the postnatal 6-8-week, and to the postnatal 6-month measurements.
Conclusion: The use of FA supplements can be effective in preventing symptoms of anxiety and depression in the antenatal and postnatal period.

Project Number

yok

References

  • World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization, 2016.
  • Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, et al. Folic acid supplementation for the prevention of neural tube defects: US Preventive Services Task Force recommendation statement. JAMA 2017;317:183–9.
  • World Health Organization. (2017). Global diffusion of eHealth: making universal health coverage achievable: report of the third global survey on eHealth. World Health Organization.
  • Güler B, Bilgiç D, Okumuş H, Yağcan H. Gebelikte beslenme desteğine ilişkin güncel rehberlerin incelenmesi. Dokuz Eylül Üniversitesi Hemşirelik Fakültesi Elektronik Dergisi 2019;12:143-151.
  • Toivonen KI, Lacroix E, Flynn M, et al. Folic acid supplementation during the preconception period: a systematic review and meta-analysis. Preventive medicine 2018;114:1-17.
  • Baykan Z, Ozturk A, Poyrazoglu S, Gun I. Awareness, knowledge, and use of folic acid among women: a study from Turkey. Archives of Gynecology and Obstetrics 2011;283:1249–1253. Basgul A, Akici A, Uzuner A, et al. Drug utilization and teratogenicity risk categories during pregnancy. Advances in Therapy 2007;24: 68–80. Özer A, Özer S, Pektaş Kanat M, et al. How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine 2016;7:538-541.
  • Yan J, Liu Y, Cao L, et al. Association between duration of folic acid supplementation during pregnancy and risk of postpartum depression. Nutrients 2017;9:1206.
  • Papakostas GI, Shelton RC, Zajecka JM, et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatr. 2012;169:1267–74.
  • Perez-Cornago A, Lopez-Legarrea P, Iglesia RDL, et al. Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic syndrome after following a weight loss treatment: the RESMENA project. Clin Nutr. 2014;33:1061–7
  • Murakami K, Sasaki S. Dietary intake and depressive symptoms: a systematic review of observational studies. Molecular nutrition & food research 2010;54: 471-488.
  • Murakami K, Mizoue T, Sasaki S, et al. Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition 2008;24:140-147.
  • Lewis SJ, Araya R, Leary S, Smith GD, Ness A. Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. Eur. J. Clin. Nutr. 2012;66: 97–103.
  • Chang F, Fan X, Zhang Y, Tang B, Jia X. Prevalence of depressive symptoms and correlated factors among pregnant women during their second and third trimesters in northwest rural China: a cross-sectional study. BMC Pregnancy and Childbirth 2022;22: 1-10
  • Van Vo T, Hoa TKD, Hoang TD. Postpartum depressive symptoms and associated factors in married women: A Cross-sectional study in Danang City. Front. Public Health 2017;5:93.
  • Gökbulut N, Bal Z. The relationship of mental well-being with healthy living awareness. Anatolian J Health Res. 2021;2:51-56
  • Hassani KF, Shiri R, Dennis CL. The prevalence of antenatal and postnatal co-morbid anxiety and depression: A meta-analysis. Psychol Med. 2017;47:2041-2053.
  • Sunay Z, Okyay E K, Gökbulut N, Uçar T. The Relationship of Postpartum Depression with Personality Traits. Journal of Inonu University Health Services Vocational School 2021;9: 219-229.
  • Dağlar G, Nur N, Bilgiç D, Kadıoğlu M. Affective Disorders in Pregnancy. Affective Disorders in Pregnancy 2015;2:27-40.
  • Ulusoy M, Şahin NH, Erkmen H. Turkish Version of The Beck Anxiety Inventory: Psychometric Properties. Journal of Cognitive Psychotherapy 1998;12:163-172.
  • Engindeniz AN, Küey L, Kültür S. The validity and reliability study of the Turkish form of the Edinburgh Postpartum Depression Scale. Spring Symposiums 1996;1:51-52.
  • Nilsen RM, Leoncini E, Gastaldi P, et al. Prevalence and determinants of preconception folic acid use: an Italian multicenter survey. Italian journal of pediatrics 2016;42: 65.
  • Toivonen KI, Lacroix E, Flynn M, et al. Folic acid supplementation during the preconception period: a systematic review and meta-analysis. Preventive medicine 2018;114:1-17.
  • Tunçel NT, Süt HK. The Effect of Anxiety, Depression and Prenatal Distress Levels in Pregnancy on Prenatal Attachment. The Journal of Gynecology - Obstetrics and Neonatology 2019;16:9-17.
  • Lewis SJ, Araya R, Leary S, Smith GD, Ness A. Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. European journal of clinical nutrition 2012; 66:97-103.
  • Ramos MI, Allen LH, Haan MN, Green R, Miller JW. Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am. J. Clin. Nutr. 2004;80:1024–1028.
  • Chong MFF, Wong JXY, Colega M, Chen LW, van Dam RM, Tan CS, et al. Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study. J. Psychiatry Res. 2014;55:110–116.
  • Blunden CH, Inskip HM, Robinson SM, Cooper C, Godfrey KM, Kendrick TR. Postpartum depressive symptoms: The B-vitamin link. Ment. Health Fam. Med. 2012;9:5–13.
  • Zhao G, Ford ES, Li C, Greenlund KJ, Croft JB, Balluz LS. Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey. Nutrition journal 2011;10:1-10.
  • Zaman FK, Özkan N, Toprak D. Depression and Anxiety in Pregnancy. Konuralp Medical Journal 2018;10: 20-25.
  • Gazzino R, Marrocco W, D'Ingianna AP, Poggiogalle E, Giusti AM, Pinto A, et al. Folic acid supplementation in Italian women during pregnancy: A cross-sectional study conducted in general practice. Nutrition 2020;79:110886.
  • Pektaş İ, Zoroğlu G, Mayda AS. The Condition of Folic Acid Knowledge, Folic Acid Awareness and Folic Acid Use at Pregnants Who Appeal to Duzce University Medical Faculty Hospital Obstetrics Clinic. Duzce Medical Journal 2017;19: 65-69.
There are 31 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Zeynep Bal 0000-0003-3224-0511

Gülsüm Karslıoğlu 0000-0001-7711-4549

Tuba Uçar 0000-0002-4450-6826

Project Number yok
Publication Date December 28, 2022
Acceptance Date October 27, 2022
Published in Issue Year 2022 Volume: 47 Issue: 4

Cite

MLA Bal, Zeynep et al. “Effect of Folic Acid Supplementation on Mental Health in the Antenatal and Postnatal Period”. Cukurova Medical Journal, vol. 47, no. 4, 2022, pp. 1547-5, doi:10.17826/cumj.1167060.