Diagnostic value of systemic immune-inflammation index and red cell distribution width-lymphocyte ratio in predicting troponin elevation in carbon monoxide poisoning

Year 2022, Volume: 47 Issue: 4, 1584 - 1590, 28.12.2022

Murat Duyan , Nafis Vural

https://doi.org/10.17826/cumj.1171643

Cited By: 1

Abstract

Purpose: The aim of our study was to assess the significant value of the systemic inflammatory index (SII) and red cell distribution width/lymphocyte ratio (RLR) in patients with carbon monoxide poisoning (COP).
Materials and Methods: Based on a retrospective cross-sectional study design, this study was conducted among patients 18 years and older who presented to the hospital's emergency department with COP. The patients were separated into troponin positive and negative groups as an outcome of serial troponin measurements. Receiver operating characteristic (ROC) analysis was used to determine the cut-off value of neutrophil/lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), RLR, and SII to predict troponin positivity.
Results: This study included 195 patients with CO exposure, 50 of whom had positive troponin tests. It was discovered that the diagnostic power of NLR, RLR, MLR, and SII was acceptable for identifying troponin positivity (AUC: 0.71-0.77). According to ROC curve comparisons, there was no diagnostic difference between these inflammatory biomarkers. Increased NLR, RLR, MLR, and SII were found to be independent predictors of troponin positivity after CO exposure (Odds ratio respectively: 8.65, 4.31, 7.24, 6.31).
Conclusion: SII and RLR, which are simple, inexpensive, and easily accessible parameters, are valuable in predicting troponin positivity in COP cases.

Keywords

Carbon monoxide poisoning, cardiac injury, systemic Immune-Inflammation index, monocyte to lymphocyte ratio, RDW to lymphocyte ratio, neutrophil to lymphocyte ratio, troponin

Karbon monoksit zehirlenmesinde troponin yükselmesini öngörmede sistemik immün-inflamasyon indeksi ve eritrosit dağılım genişliği-lenfosit oranının tanısal değeri

Abstract

Amaç: Çalışmamızın amacı, karbon monoksit zehirlenmesi (KMZ) olan hastalarda sistemik inflamatuar indeks (SII) ve eritrosit dağılım genişliği/lenfosit oranının (RLR) troponin yükselmesini öngörmedeki tanısal değerini değerlendirmekti.
Gereç ve Yöntem: Retrospektif kesitsel bir çalışma tasarımına dayanan bu çalışma, hastanenin acil servisine KMZ ile başvuran 18 yaş ve üstü hastalar arasında yapıldı. Seri troponin ölçümleri sonucunda hastalar troponin pozitif ve negatif gruplara ayrıldı. Troponin pozitifliğini tahmin etmek için nötrofil/lenfosit oranı (NLR), monosit-lenfosit oranı (MLR), RLR ve SII'nin eşik değerini belirlemek için alıcı işlem karakteristiği (ROC) analizi kullanıldı..
Bulgular: Bu çalışmaya 50'sinde pozitif troponin testi bulunan CO maruziyeti olan 195 hasta dahil edildi. NLR, RLR, MLR ve SII'nin troponin pozitifliğini belirlemek için tanısal gücünün kabul edilebilir olduğu keşfedildi (AUC: 0.71-0.77). ROC eğrisi karşılaştırmalarına göre, bu inflamatuar biyobelirteçler arasında tanısal bir fark yoktu. Artan NLR, RLR, MLR ve SII'nin CO maruziyetinden sonra troponin pozitifliğinin bağımsız öngörücüleri olduğu bulundu (Odds oranı sırasıyla: 8.65, 4.31, 7.24, 6.31).
Sonuç: Basit, ucuz ve kolay erişilebilir parametreler olan SII ve RLR, COP olgularında troponin pozitifliğini öngörmede değerlidir.

Keywords

Karbon monoksit zehirlenmesi, kardiyak hasar, sistemik immün-inflamasyon indeks, monosit-lenfosit oranı, RDW-lenfosit oranı, nötrofil-lenfosit oranı, troponin.

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