Bipolar I bozukluk tanılı hastalarda zihin kuramının, metabolik parametreler ve işlevsellik ile ilişkisi

Year 2022, Volume: 47 Issue: 4, 1610 - 1619, 28.12.2022

Filiz Kulacaoğlu , Hasan Ünver , Yusuf Ezel Yıldırım , Gamze Erzin

https://doi.org/10.17826/cumj.1179024

Abstract

Amaç: Bu çalışmada bipolar bozukluk-1 (BB-1) tanılı hastaların remisyon dönemlerindeki zihin kuramı becerileri ile, işlevsellik ve metabolik değişimleri arasındaki ilişkiyi araştırmayı amaçladık.
Gereç ve Yöntem: Bu kesitsel çalışma, remisyonda BB-1 tanılı 68 hasta ve 45 sağlıklı kontrolden oluşmaktadır. Katılımcılara sosyodemografik form, Gözlerden Zihin Okuma Testi, Bipolar Bozukluk İşlevsellik Anketi uygulandı. Katılımcıların beden kitle indeksi (BKİ), bel çevresi (BÇ), açlık plazma glukozu (PG), yüksek yoğunluklu lipoprotein kolesterol (HDL), düşük yoğunluklu lipoprotein kolesterol (LDL), toplam kolesterol, trigliserit (TG) seviyeleri kaydedildi.
Bulgular: Hasta grubu ile sağlıklı kontrol grubu arasında BÇ, BKİ, HDL, LDL, TG düzeyleri açısından anlamlı farklılıklar vardı. Bağımsız örnekler t-testi sonuçlarına göre kontrol grubunda hasta grubuna göre Gözlerden Zihin Okuma Testi’nde istatistiki olarak anlamlı daha yüksek skorlar elde edilmiştir.
Sonuç: Remisyon döneminde BB-1 tanılı hastalar, sağlıklı kontrollere göre zihin kuramı becerilerinde daha düşük performansa ve metabolik parametrelerde daha fazla değişikliğe sahiptir. Metabolik değişiklik ve zihin bozukluğu teorisi, BD için potansiyel tedavi hedefi olmalıdır.

Keywords

Zihin kuramı, bipolar bozukluk, metabolik disfonksiyon, Theory of mind, bipolar disorder, metabolic dysfunction

Relationship between theory of mind and metabolic parameters and functioning in patients with bipolar I disorder

Abstract

Purpose: We aimed to investigate the relationship theory of mind abilities with functionality and metabolic alteration in patients with bipolar disorder-1 (BD-1) during the remission period.
Materials and Methods: This cross-sectional study is consisted of 68 patients with bipolar disorder-1 and 45 healthy controls. Sociodemographic form, Reading the Mind in the Eyes Test (RMET), Bipolar Disorder Functioning Questionnaire (BDFQ) were administered to the participants. Body mass index (BMI), waist circumference (WC), fasting plasma glucose (FG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), total cholesterol (TC), triglyceride (TG) levels were recorded.
Results: There were significant differences between the patient group and healthy control group in terms of WC, BMI, HDL, LDL, TG. The results of independent samples t-test indicated a statistically significant difference in RMET score between the two groups with control group significantly higher than patient group.
Conclusion: Patients with BD-1 during the remission period have lower performance on theory of mind abilities and more alteration in metabolic parameters than healthy controls. Metabolic alteration and theory of mind impairment should be potential treatment target for BD

Keywords

Theory of mind, bipolar disorder, metabolic dysfunction

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