A neonatal lupus syndrome with pericardial tamponade due to maternal Sjögren’s syndrome

Year 2023, Volume: 48 Issue: 2, 745 - 747, 02.07.2023

Hacer Yapıcıoğlu , Mustafa Özdemir , Tugay Tepe , Tolga Akbaş , Ferda Özlü , Sevcan Erdem

https://doi.org/10.17826/cumj.1241756

Abstract

Neonatal lupus syndrome (NLS) is a rare disease with dermatological, cardiac, hepatic and hematologic involvement due to placental transfer of anti-Ro/ SSA and anti-La/ SSB antibodies in infants of mothers with autoimmune diseases. Multisystemic involvement is common in infants. Here we present a baby with neonatal lupus syndrome whose mother had Sjögren's syndrome. He presented with thrombocytopenia, then convulsion and cardiac arrest due to pericardial tamponade. So, the risk of NLS should be kept in mind in infants of mothers with autoimmune diseases.

Keywords

Sjögren’s syndrome, Neonatal lupus syndrome, Convulsion, Pericardial tamponade

Maternal Sjögren sendromuna bağlı perikardiyal tamponadı olan neonatal lupus sendromu

Abstract

Neonatal lupus sendromu (NLS), otoimmün hastalığı olan annelerin bebeklerinde anti-Ro/ SSA ve anti-La/ SSB antikorlarının plasental transferine bağlı olarak dermatolojik, kardiyak, hepatik ve hematolojik tutulumla seyreden nadir bir hastalıktır. Bebeklerde multisistemik tutulum sık görülür. Burada, annesinde Sjögren sendromu olan neonatal lupus sendromlu bir olgu sunulmuştur. Bebekte önce trombositopeni, ardından konvülsiyon ve perikardiyal tamponada ikincil kardiyak arrest gelişmiştir. Otoimmün hastalığı olan annelerin bebeklerinde NLS riski akılda tutulmalıdır.

Keywords

Sjögren sendromu, Neonatal lupus sendromu, Konvülziyon, Perikardiyal tamponad

References

• Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med. 2004;164:1275–84.
• Vanoni F, Lava SAG, Fossali EF, Cavalli R, Simonetti GD, Bianchetti MG et al. Neonatal systemic lupus erythematosus syndrome: a Comprehensive Review. Clin Rev Allergy Immunol. 2017;53:469–76.
• Izmirly PM, Costedoat-Chalumeau N, Pisoni CN, Khamashta MA, Kim MY, Saxena A et al. Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/ro-antibody - associated cardiac manifestations of neonatal lupus. Circulation. 2012;126:76–82.
• Klein-Gitelman MS. Neonatal Lupus: What we have learned and current approaches to care. Curr Rheumatol Rep. 2016;18.
• Frankovich J, Sandborg C, Barnes P, Hintz S. Neonatal lupus and related autoimmune disorders of infants. Neoreviews. 2008;9:e206–17.
• Derdulska JM, Rudnicka L, Szykut-Badaczewska A, Mehrholz D, Nowicki RJ, Barańska-Rybak W et al. Neonatal lupus erythematosus - practical guidelines. J Perinat Med. 2021;49:529–38.
• Flint J, Panchal S, Hurrell A, van de Venne M, Gayed M, Schreiber K et al. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding-Part I: Standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford). 2016;55:1693–7.
• Jayaprasad N, Johnson F, Venugopal K. Congenital complete heart block and maternal connective tissue disease. Vol. 112, Int J Cardiol. 2006;153–8.
• Glatz AC, Gaynor JW, Rhodes LA, Rychik J, Tanel RE, Vetter VL et al. Outcome of high-risk neonates with congenital complete heart block paced in the first 24 hours after birth. J Thorac Cardiovasc Surg. 2008;136:767–73.
• Li X, Huang X, Lu H. Two case reports of neonatal autoantibody-associated congenital heart block. Medicine (Baltimore). 2018;97:e13185.
• Morel N, Lévesque K, Maltret A, Baron G, Hamidou M, Orquevaux P et al. Incidence, risk factors, and mortality of neonatal and late-onset dilated cardiomyopathy associated with cardiac neonatal lupus. Int J Cardiol. 2017;248:263–9.
• Moak JP, Barron KS, Hougen TJ, Wiles HB, Balaji S, Sreeram N et al. Congenital heart block: Development of late-onset cardiomyopathy, a previously underappreciated sequela. J Am Coll Cardiol. 2001;37:238–42.
• Eronen M, Heikkilä P, Teramo K. Congenital complete heart block in the fetus: Hemodynamic features, antenatal treatment, and outcome in six cases. Pediatr Cardiol. 2001;22:385–92.