İnsülin direnci seboreik dermatitte yeni bir komorbidite mi: bir vaka kontrol çalışması

Year 2023, Volume: 48 Issue: 4, 1293 - 1298, 29.12.2023

Burak Akşan , Oguz Dikbas

https://doi.org/10.17826/cumj.1354195

Abstract

Amaç: Seboreik dermatit (SD), etiyolojisi bilinmeyen kronik inflamatuar bir deri hastalığıdır. Mevcut çaışmalardan elde edilen veriler obezitesi olan bireylerde SD prevalansının daha yüksek olduğunu göstermektedir. İnsülin direnci (IR), kandaki glisemiyi dengelemek için gereken yüksek insülin seviyeleri ile karakterize edilen metabolik bir durumdur ve obezite bunun klinik belirtilerinden biridir. Bu çalışma literatürde insülin direnci IR ile SD arasındaki ilişkiyi ortaya koyan ilk prospektif araştırmalardan birini sunmaktadır.
Gereç ve Yöntem: Bu vaka-kontrol çalışmasına toplam 71 katılımcı dahil edildi: 35 SD hastası (15 erkek/20 kadın) ve 36 kontrol (15 erkek/21 kadın). Tüm katılımcılar aynı dermatoloji uzmanı tarafından seboreik dermatit varlığı veya yokluğu açısından klinik olarak değerlendirildi. Her iki grupta da HOMA-IR, insülin seviyeleri, serum lipit seviyeleri, bel çevresi ve vücut kitle indeksi (BMI) gibi parametreler ölçüldü.
Bulgular: SD'li hastalarda HOMA-IR, insülin, toplam kolesterol, LDL kolesterol, bel çevresi ve BMI düzeyleri kontrol grubuyla karşılaştırıldığında daha yüksekti. HOMA-IR ile bel çevresi, BMI, diyastolik kan basıncı ve trigliserit düzeyleri arasında anlamlı pozitif korelasyonlar bulundu.
Sonuç: Bu çalışma insülin direncinin IR'nin seboreik dermatitte yeni bir komorbid faktör olabileceğini düşündürmektedir. SD ile insülin direnci arasında muhtemelen ortak inflamatuar patogenezden dolayı önemli bir ilişki gözlendi. Sonuç olarak, sağlıklı bir yaşam tarzı sürdürmenin önemi vurgulanarak SD'li bireyler insülin direnciyle ilişkili durumlar açısından izlenmelidir.

Keywords

Seboreik dermatit, insülin direnci, komorbidite

Is insulin resistance a new comorbidity in seborrheic dermatitis: a case control study

Abstract

Purpose: Seborrheic dermatitis (SD) is a chronic inflammatory skin disorder with an unknown etiology. Data from studies show that the prevalence of SD is higher in individuals with obesity. Insulin resistance (IR) is a metabolic condition characterized by high levels of insulin required to balance blood glycemia, and obesity is one of its clinical manifestations. This study presents one of the first prospective studies revealing the relationship between IR and SD in the literature.
Materials and Methods: In this case-control study, a total of 71 participants were included: 35 SD patients (15 males/20 females) and 36 controls (15 males/21 females). All participants were clinically evaluated for the presence or absence of seborrheic dermatitis by the same dermatologist. Parameters including HOMA-IR, insulin levels, serum lipid levels, waist circumference, and BMI were measured in both groups.
Results: HOMA-IR, insulin, total cholesterol, LDL cholesterol, waist circumference and BMI levels were higher in SD patients compared to the control group. Significant positive correlations were found between HOMA-IR and waist circumference, BMI, diastolic blood pressure, and triglyceride levels.
Conclusion: This study suggests that IR could be a new comorbid factor in seborrheic dermatitis. A substantial association was observed between SD and insulin resistance, possibly due to shared inflammatory pathogenesis. Consequently, individuals with SD should be monitored for insulin resistance-related conditions, emphasizing the importance of maintaining a healthy lifestyle.

Keywords

Seborrheic dermatitis, insulin resistance, comorbidity

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