Anticholinesterase, Antidiabetic and Antioxidant Activities of Chloroform Extract of Genista carinalis

Year 2023, Volume: 6 Issue: 1, 1 - 6, 02.07.2023

Hilmican Çalışkan , Hakime Hülya Orak , Cansel Cakır , Merve Argon , Temine Şabudak , Mehmet Öztürk , Necmettin Güler

https://doi.org/10.38093/cupmap.1229198

Abstract

Alzheimer's disease, diabetes has become an increasing public health issues in recent years. On the other hand, synthetic drugs are expensive, could be inadequate to treat diseases, could be cause irritation, and side effects. Therefore, increasingly more researchis being done to plant-derived formulas, bioactive ingredients, which can be an alternative to synthetic drugs for treatments to solve basic health problems. In this study the antioxidant, anticholinesterase and antidiabetic activities of G. carinalis in the chloroform extract were determined. Based on the results, the extract was not observed inhibitory activities of α-glucosidase and α-amylase. It showed better activity for acetylcholiesterase activity than the butylrylcholinesterase activity. The antioxidant potential of G. carinalis chloroform extract was determined with different assays. The TEAC value was determined to be 0.484 mmol TE/g, FRAP value was found to be 1023.20 µmol Fe2+/g for G. carinalis chloroform extract. The EC50 value of DPPH assays for extract was found to be 0.101 μg/ml.

Keywords

Genista, G. carinalis, Anticholinesterase activity, Butyrylcholinesterase activity, TEAC, α-Amylase.

Supporting Institution

Scientific Research Projects Coordination Unit of Tekirdag Namik Kemal University

Project Number

NKUBAP.01.DR.22.352

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