From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease

Year 2024, , 35 - 53, 29.04.2024

Hakan Koç , Muhammet İlker Kaya Nizameddin Koca

https://doi.org/10.56016/dahudermj.1459557

Abstract

In the realm of granulomatous diseases, the convergence of pathophysiology, epidemiology, and therapeutic strategies presents a labyrinth of complexity with far-reaching clinical implications. This review embarks on a scholarly expedition through the intricate landscape of granulomatous inflammation, dissecting the multifaceted presentations ranging from infectious etiologies to enigmatic autoimmune disorders. With a discerning eye on recent advancements and literature, we unravel the nuanced interactions between host defenses and granuloma formation, alongside the pivotal role of cytokines and mononuclear cells in orchestrating these responses. Beyond a mere academic exercise, our exploration delves into the clinical juxtaposition of common and esoteric causes, offering a panoramic view on diagnostic methodologies that straddle the traditional and the innovative. The management of granulomatous diseases, often a tightrope walk balancing efficacy and toxicity, is critically examined, shedding light on conventional and emerging therapies that promise to reshape the therapeutic landscape. By weaving together threads of current research, this review aspires to enhance the understanding of granulomatous diseases and catalyze future inquiries into their mysteries. In doing so, it stands as a beacon for clinicians.

Keywords

Granulomatous Disease, granuloma, cytokines, mononuclear cell, tuberculosis, brucellosis, sarcoidosis, Q fever, Wegener

Ethical Statement

The local ethics committee approval (2011-KAEK-25 2019/07-01) was obtained, and the study was carried out in accordance with the declaration of Helsinki. A written informed consent was obtained from all participants.

Thanks

I would like to thank my estimable teacher Assoc. Prof. Dr. Nizameddin KOCA, who always supported his students in our Internal Medicine training, contributed to our progress and guided us, my colleague Dr. Muhammet İlker KAYA and my wife Lecturer Ayşe BAŞTUĞ KOÇ, who always supported me.

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