A case of recurrent acute pancreatitis following ocrelizumab use

Year 2024, Volume: 4 Issue: 2, 61 - 63, 29.04.2024

Elif Işıklar , Berivan Akdoğan Uygar Yavaş İsmail Demir

https://doi.org/10.56016/dahudermj.1267120

Abstract

Acute pancreatitis is an acute inflammatory process of the pancreas. Drugs are a relatively rare cause of acute pancreatitis with an incidence of 0.1-2%. Ocrelizumab is a monoclonal antibody that causes peripheral B lymphocyte suppression by targeting CD20 receptors on B lymphocytes. In this case report, we aimed to present a case of acute pancreatitis after ocrelizumab use. It is thought that suppression of B lymphocytes by ocrelizumab may induce proinflammatory cytokine release and may also cause pancreatitis by disrupting T lymphocyte regulation. Therefore, ocrelizumab should be considered in the etiology of pancreatitis in patients receiving ocrelizumab treatment.

Keywords

Ocrelizumab, Pancreatitis, MONOCLONAL ANTİBODY

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